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RNF112 ring finger protein 112 [ Homo sapiens (human) ]

Gene ID: 7732, updated on 10-Dec-2024

Summary

Official Symbol
RNF112provided by HGNC
Official Full Name
ring finger protein 112provided by HGNC
Primary source
HGNC:HGNC:12968
See related
Ensembl:ENSG00000128482 MIM:601237; AllianceGenome:HGNC:12968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BFP; ZNF179
Summary
This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 6.0), prostate (RPKM 2.1) and 11 other tissues See more
Orthologs
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Genomic context

See RNF112 in Genome Data Viewer
Location:
17p11.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (19411232..19417276)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (19359261..19365304)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19314545..19320589)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19286483-19286983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19288791-19289336 Neighboring gene mitogen-activated protein kinase 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19289337-19289882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19289883-19290428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19294419-19295332 Neighboring gene microfibril associated protein 4 Neighboring gene uncharacterized LOC124903947 Neighboring gene long intergenic non-protein coding RNA 2094 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:19336510-19337048 Neighboring gene uncharacterized LOC105371574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:19344229-19345013 Neighboring gene ribosomal protein S2 pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ99413

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G1 to G0 transition involved in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hydroperoxide ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
RING finger protein 112
Names
brain finger protein
neurolastin
zinc finger protein 179
NP_009079.2
XP_006721634.1
XP_006721635.1
XP_006721636.1
XP_047292622.1
XP_047292623.1
XP_054173048.1
XP_054173049.1
XP_054173050.1
XP_054173051.1
XP_054173052.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007148.5NP_009079.2  RING finger protein 112

    See identical proteins and their annotated locations for NP_009079.2

    Status: REVIEWED

    Source sequence(s)
    BC053989, BE297851
    Consensus CDS
    CCDS58529.1
    UniProtKB/Swiss-Prot
    O60633, Q7Z5V9, Q9ULX5
    Related
    ENSP00000454919.1, ENST00000461366.2
    Conserved Domains (2) summary
    cd01851
    Location:163394
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cl17238
    Location:55102
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    19411232..19417276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721571.5XP_006721634.1  RING finger protein 112 isoform X1

    Conserved Domains (2) summary
    cd01851
    Location:163402
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd00162
    Location:56101
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_006721572.5XP_006721635.1  RING finger protein 112 isoform X2

    Conserved Domains (2) summary
    cd01851
    Location:162401
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd00162
    Location:56101
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_047436666.1XP_047292622.1  RING finger protein 112 isoform X4

  4. XM_006721573.3XP_006721636.1  RING finger protein 112 isoform X3

    Conserved Domains (2) summary
    cd01851
    Location:139378
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd00162
    Location:3277
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  5. XM_047436667.1XP_047292623.1  RING finger protein 112 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    19359261..19365304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317073.1XP_054173048.1  RING finger protein 112 isoform X1

  2. XM_054317074.1XP_054173049.1  RING finger protein 112 isoform X2

  3. XM_054317076.1XP_054173051.1  RING finger protein 112 isoform X4

  4. XM_054317075.1XP_054173050.1  RING finger protein 112 isoform X3

  5. XM_054317077.1XP_054173052.1  RING finger protein 112 isoform X5