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RNF112 ring finger protein 112 [ Homo sapiens (human) ]

Gene ID: 7732, updated on 1-Aug-2020

Summary

Official Symbol
RNF112provided by HGNC
Official Full Name
ring finger protein 112provided by HGNC
Primary source
HGNC:HGNC:12968
See related
Ensembl:ENSG00000128482 MIM:601237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BFP; ZNF179
Summary
This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 6.0), prostate (RPKM 2.1) and 11 other tissues See more
Orthologs

Genomic context

See RNF112 in Genome Data Viewer
Location:
17p11.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (19406979..19417276)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19314491..19320589)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene B9 domain containing 1 Neighboring gene uncharacterized LOC105371573 Neighboring gene mitogen-activated protein kinase 7 Neighboring gene microfibril associated protein 4 Neighboring gene uncharacterized LOC105371574 Neighboring gene long intergenic non-protein coding RNA 2094 Neighboring gene ribosomal protein S2 pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99413

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein self-association ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell death in response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
cell death in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hydroperoxide ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nuclear body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
RING finger protein 112
Names
brain finger protein
neurolastin
zinc finger protein 179
NP_009079.2
XP_006721634.1
XP_006721635.1
XP_006721636.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007148.5NP_009079.2  RING finger protein 112

    See identical proteins and their annotated locations for NP_009079.2

    Status: REVIEWED

    Source sequence(s)
    BC053989, BE297851
    Consensus CDS
    CCDS58529.1
    UniProtKB/Swiss-Prot
    Q9ULX5
    Related
    ENSP00000454919.1, ENST00000461366.2
    Conserved Domains (2) summary
    cd01851
    Location:163394
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cl17238
    Location:55102
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    19406979..19417276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721571.4XP_006721634.1  RING finger protein 112 isoform X1

    Conserved Domains (2) summary
    cd01851
    Location:163402
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd00162
    Location:56101
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_006721572.4XP_006721635.1  RING finger protein 112 isoform X2

    Conserved Domains (2) summary
    cd01851
    Location:162401
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd00162
    Location:56101
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_006721573.3XP_006721636.1  RING finger protein 112 isoform X3

    Conserved Domains (2) summary
    cd01851
    Location:139378
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd00162
    Location:3277
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
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