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TRIM26 tripartite motif containing 26 [ Homo sapiens (human) ]

Gene ID: 7726, updated on 4-Nov-2018

Summary

Official Symbol
TRIM26provided by HGNC
Official Full Name
tripartite motif containing 26provided by HGNC
Primary source
HGNC:HGNC:12962
See related
Ensembl:ENSG00000234127 MIM:600830; Vega:OTTHUMG00000031041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFP; RNF95; ZNF173
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in kidney (RPKM 14.9), spleen (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See TRIM26 in Genome Data Viewer
Location:
6p22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (30184453..30213494, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30152232..30181271, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 40 Neighboring gene tripartite motif containing 10 Neighboring gene tripartite motif containing 15 Neighboring gene poly(A) binding protein interacting protein 1 pseudogene 1 Neighboring gene tripartite motif containing 26B, pseudogene Neighboring gene HLA complex group 17 Neighboring gene major histocompatibility complex, class I, L (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies five new schizophrenia loci.
NHGRI GWA Catalog
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.
NHGRI GWA Catalog
Genome-wide association study of proneness to anger.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16483

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 26
Names
RING finger protein 95
acid finger protein
widely expressed acid zinc finger protein
zinc finger protein 173
NP_001229712.1
NP_003440.1
XP_005249431.1
XP_005249432.1
XP_005249433.1
XP_005249434.1
XP_005249435.1
XP_006715243.1
XP_011513161.1
XP_016866752.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242783.1NP_001229712.1  tripartite motif-containing protein 26

    See identical proteins and their annotated locations for NP_001229712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC032297, DA234548
    Consensus CDS
    CCDS4678.1
    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Related
    ENSP00000391879.1, OTTHUMP00000161458, ENST00000453195.5, OTTHUMT00000253441
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_003449.4NP_003440.1  tripartite motif-containing protein 26

    See identical proteins and their annotated locations for NP_003440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC024039, DA234548
    Consensus CDS
    CCDS4678.1
    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Related
    ENSP00000410446.2, OTTHUMP00000161459, ENST00000454678.6, OTTHUMT00000253442
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    30184453..30213494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249378.2XP_005249435.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249435.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_017011263.1XP_016866752.1  tripartite motif-containing protein 26 isoform X2

    Conserved Domains (3) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:237461
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cl17238
    Location:1656
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_006715180.2XP_006715243.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_006715243.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_005249375.2XP_005249432.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249432.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_011514859.1XP_011513161.1  tripartite motif-containing protein 26 isoform X2

    See identical proteins and their annotated locations for XP_011513161.1

    Conserved Domains (3) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:237461
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cl17238
    Location:1656
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  6. XM_005249374.2XP_005249431.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249431.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Related
    ENSP00000395491.1, OTTHUMP00000161460, ENST00000437089.5, OTTHUMT00000253443
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_005249376.2XP_005249433.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249433.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_005249377.2XP_005249434.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249434.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    1442506..1471549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    1664235..1693265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    1440327..1469370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p12 ALT_REF_LOCI_4

    Range
    1495111..1524147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p12 ALT_REF_LOCI_5

    Range
    1528484..1557367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p12 ALT_REF_LOCI_6

    Range
    1439551..1468596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p12 ALT_REF_LOCI_7

    Range
    1483342..1512385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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