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TRIM26 tripartite motif containing 26 [ Homo sapiens (human) ]

Gene ID: 7726, updated on 24-Nov-2020

Summary

Official Symbol
TRIM26provided by HGNC
Official Full Name
tripartite motif containing 26provided by HGNC
Primary source
HGNC:HGNC:12962
See related
Ensembl:ENSG00000234127 MIM:600830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFP; RNF95; ZNF173
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in kidney (RPKM 14.9), spleen (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See TRIM26 in Genome Data Viewer
Location:
6p22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30184453..30213435, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30152232..30181271, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 10 Neighboring gene tripartite motif containing 15 Neighboring gene poly(A) binding protein interacting protein 1 pseudogene 1 Neighboring gene tripartite motif containing 26B, pseudogene Neighboring gene HLA complex group 17 Neighboring gene major histocompatibility complex, class I, L (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies five new schizophrenia loci.
GeneReviews: Not available
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.
GeneReviews: Not available
Genome-wide association study of proneness to anger.
GeneReviews: Not available
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16483

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral release from host cell IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 26
Names
RING finger protein 95
acid finger protein
widely expressed acid zinc finger protein
zinc finger protein 173
NP_001229712.1
NP_003440.1
XP_005249431.1
XP_005249432.1
XP_005249433.1
XP_005249434.1
XP_005249435.1
XP_006715243.1
XP_011513161.1
XP_016866752.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242783.2NP_001229712.1  tripartite motif-containing protein 26

    See identical proteins and their annotated locations for NP_001229712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC032297, DA234548
    Consensus CDS
    CCDS4678.1
    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Related
    ENSP00000391879.1, ENST00000453195.5
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_003449.5NP_003440.1  tripartite motif-containing protein 26

    See identical proteins and their annotated locations for NP_003440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC024039, DA234548
    Consensus CDS
    CCDS4678.1
    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Related
    ENSP00000410446.2, ENST00000454678.7
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30184453..30213435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249378.2XP_005249435.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249435.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_017011263.1XP_016866752.1  tripartite motif-containing protein 26 isoform X2

    Conserved Domains (3) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:237461
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cl17238
    Location:1656
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_006715180.2XP_006715243.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_006715243.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_005249375.2XP_005249432.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249432.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_011514859.1XP_011513161.1  tripartite motif-containing protein 26 isoform X2

    See identical proteins and their annotated locations for XP_011513161.1

    Conserved Domains (3) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:237461
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cl17238
    Location:1656
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  6. XM_005249374.2XP_005249431.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249431.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Related
    ENSP00000395491.1, ENST00000437089.5
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_005249376.2XP_005249433.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249433.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_005249377.2XP_005249434.1  tripartite motif-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_005249434.1

    UniProtKB/Swiss-Prot
    Q12899
    UniProtKB/TrEMBL
    A0A024RCP3
    Conserved Domains (4) summary
    smart00336
    Location:97138
    BBOX; B-Box-type zinc finger
    cd15826
    Location:314538
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16598
    Location:1357
    RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
    cl25732
    Location:145304
    SMC_N; RecF/RecN/SMC N terminal domain

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1442506..1471461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    1664235..1693177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1440327..1469282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    1495111..1524059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    1528484..1557367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1439551..1468508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    1483342..1512297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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