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Ocel1 occludin/ELL domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 77090, updated on 2-Nov-2024

Summary

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Official Symbol
Ocel1provided by MGI
Official Full Name
occludin/ELL domain containing 1provided by MGI
Primary source
MGI:MGI:1924340
See related
Ensembl:ENSMUSG00000002396 AllianceGenome:MGI:1924340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9430098E02Rik
Summary
Predicted to be involved in bicellular tight junction assembly. Predicted to be active in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Orthologous to human OCEL1 (occludin/ELL domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum adult (RPKM 21.3), small intestine adult (RPKM 18.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ocel1 in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71823942..71826333)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71371298..71373689)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene 4HAUS augmin-like complex, subunit 8 Neighboring gene STARR-positive B cell enhancer ABC_E1105 Neighboring gene myosin IXb Neighboring gene STARR-positive B cell enhancer ABC_E6650 Neighboring gene unconventional SNARE in the ER 1 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_21812 Neighboring gene nuclear receptor subfamily 2, group F, member 6 Neighboring gene USH1 protein network component harmonin binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
occludin/ELL domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293800.1 → NP_001280729.1  occludin/ELL domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK163762
    Consensus CDS
    CCDS80892.1
    UniProtKB/TrEMBL
    D3Z3P2
    Related
    ENSMUSP00000105678.2, ENSMUST00000110051.2

  2. NM_029865.2 → NP_084141.2  occludin/ELL domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_084141.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC127416, AK020528, AK163762, BY542600
    Consensus CDS
    CCDS22391.1
    UniProtKB/Swiss-Prot
    Q3U2L0, Q8VCR9, Q9CX17
    UniProtKB/TrEMBL
    G5E815
    Related
    ENSMUSP00000002469.9, ENSMUST00000002469.9
    Conserved Domains (1) summary
    pfam07303
    Location:109 → 206
    Occludin_ELL; Occludin homology domain

RNA

  1. NR_122030.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK163762, BB766991

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71823942..71826333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCR9.1 GenPept UniProtKB/Swiss-Prot:Q8VCR9

Gene LinkOut

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