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PCGF2 polycomb group ring finger 2 [ Homo sapiens (human) ]

Gene ID: 7703, updated on 7-Dec-2018

Summary

Official Symbol
PCGF2provided by HGNC
Official Full Name
polycomb group ring finger 2provided by HGNC
Primary source
HGNC:HGNC:12929
See related
Ensembl:ENSG00000277258 MIM:600346
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEL-18; RNF110; ZNF144
Summary
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.0), thyroid (RPKM 6.9) and 24 other tissues See more
Orthologs

Genomic context

See PCGF2 in Genome Data Viewer
Location:
17q12
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (38733897..38749817, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36890150..36906070, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MLLT6, PHD finger containing Neighboring gene control region 19 heart enhancer Neighboring gene RNA, 5S ribosomal pseudogene 440 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene uncharacterized LOC100287808 Neighboring gene tRNA-Asn (GTT) 2-5 Neighboring gene RNA, U6 small nuclear 866, pseudogene Neighboring gene proteasome subunit beta 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10545

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
histone H2A-K119 monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H2A-K119 monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G0 to G1 transition TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PRC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
sex chromatin IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
polycomb group RING finger protein 2
Names
DNA-binding protein Mel-18
ring finger protein 110
zinc finger protein 144

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007144.3NP_009075.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_009075.1

    Status: REVIEWED

    Source sequence(s)
    AC006449
    Consensus CDS
    CCDS32638.1
    UniProtKB/Swiss-Prot
    P35227
    UniProtKB/TrEMBL
    A0A024R1V6
    Related
    ENSP00000482815.1, ENST00000620225.4
    Conserved Domains (4) summary
    pfam16207
    Location:164228
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cl27601
    Location:236328
    Pectinesterase; Pectinesterase
    cl28410
    Location:8175
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    38733897..38749817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257640.2XP_005257697.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005257697.1

    UniProtKB/Swiss-Prot
    P35227
    UniProtKB/TrEMBL
    A0A024R1V6
    Related
    ENSP00000482063.1, ENST00000616199.4
    Conserved Domains (4) summary
    pfam16207
    Location:164228
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cl27601
    Location:236328
    Pectinesterase; Pectinesterase
    cl28410
    Location:8175
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  2. XM_017025016.1XP_016880505.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P35227
    UniProtKB/TrEMBL
    A0A024R1V6
    Conserved Domains (4) summary
    pfam16207
    Location:164228
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cl27601
    Location:236328
    Pectinesterase; Pectinesterase
    cl28410
    Location:8175
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  3. XM_005257642.3XP_005257699.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005257699.1

    UniProtKB/Swiss-Prot
    P35227
    UniProtKB/TrEMBL
    A0A024R1V6
    Conserved Domains (4) summary
    pfam16207
    Location:164228
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cl27601
    Location:236328
    Pectinesterase; Pectinesterase
    cl28410
    Location:8175
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  4. XM_005257641.5XP_005257698.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005257698.1

    UniProtKB/Swiss-Prot
    P35227
    UniProtKB/TrEMBL
    A0A024R1V6
    Related
    ENSP00000478970.1, ENST00000611883.4
    Conserved Domains (4) summary
    pfam16207
    Location:164228
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cl27601
    Location:236328
    Pectinesterase; Pectinesterase
    cl28410
    Location:8175
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    2769216..2783624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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