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PCGF2 polycomb group ring finger 2 [ Homo sapiens (human) ]

Gene ID: 7703, updated on 5-Sep-2021

Summary

Official Symbol
PCGF2provided by HGNC
Official Full Name
polycomb group ring finger 2provided by HGNC
Primary source
HGNC:HGNC:12929
See related
Ensembl:ENSG00000277258 MIM:600346
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPFS; MEL-18; RNF110; ZNF144
Summary
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.0), thyroid (RPKM 6.9) and 24 other tissues See more
Orthologs
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Genomic context

See PCGF2 in Genome Data Viewer
Location:
17q12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (38733898..38749817, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36890151..36904589, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MLLT6, PHD finger containing Neighboring gene control region 19 heart enhancer Neighboring gene RNA, 5S ribosomal pseudogene 440 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene uncharacterized LOC100287808 Neighboring gene tRNA-Asn (anticodon GTT) 2-5 Neighboring gene RNA, U6 small nuclear 866, pseudogene Neighboring gene proteasome 20S subunit beta 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10545

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in sex chromatin IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
polycomb group RING finger protein 2
Names
DNA-binding protein Mel-18
ring finger protein 110
zinc finger protein 144

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369614.1NP_001356543.1  polycomb group RING finger protein 2

    Status: REVIEWED

    Source sequence(s)
    AC006449
    Conserved Domains (3) summary
    PLN02217
    Location:236328
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  2. NM_001369615.1NP_001356544.1  polycomb group RING finger protein 2

    Status: REVIEWED

    Source sequence(s)
    AC006449, D13969
    Related
    ENSP00000478970.1, ENST00000611883.4
    Conserved Domains (3) summary
    PLN02217
    Location:236328
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  3. NM_007144.3NP_009075.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_009075.1

    Status: REVIEWED

    Source sequence(s)
    AC006449
    Consensus CDS
    CCDS32638.1
    UniProtKB/Swiss-Prot
    P35227
    UniProtKB/TrEMBL
    A0A024R1V6
    Related
    ENSP00000482815.1, ENST00000620225.5
    Conserved Domains (3) summary
    PLN02217
    Location:236328
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    38733898..38749817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257640.2XP_005257697.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005257697.1

    UniProtKB/Swiss-Prot
    P35227
    UniProtKB/TrEMBL
    A0A024R1V6
    Related
    ENSP00000482063.1, ENST00000616199.4
    Conserved Domains (3) summary
    PLN02217
    Location:236328
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  2. XM_017025016.1XP_016880505.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P35227
    UniProtKB/TrEMBL
    A0A024R1V6
    Conserved Domains (3) summary
    PLN02217
    Location:236328
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2769217..2783655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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