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Pcgf2 polycomb group ring finger 2 [ Mus musculus (house mouse) ]

Gene ID: 22658, updated on 26-Sep-2022

Summary

Official Symbol
Pcgf2provided by MGI
Official Full Name
polycomb group ring finger 2provided by MGI
Primary source
MGI:MGI:99161
See related
Ensembl:ENSMUSG00000018537 AllianceGenome:MGI:99161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mel18; Rnf110; Zfp144; mel-18
Summary
Enables chromatin binding activity. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of apoptotic signaling pathway. Located in nuclear body and sex chromatin. Part of PcG protein complex. Is expressed in several structures, including adipose tissue; alimentary system; brain; eye; and genitourinary system. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 21.4), whole brain E14.5 (RPKM 19.6) and 25 other tissues See more
Orthologs
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Genomic context

See Pcgf2 in Genome Data Viewer
Location:
11 D; 11 61.06 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97579647..97593260, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97688821..97702434, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 Neighboring gene microRNA 6927 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene nuclear encoded tRNA asparagine 8 (anticodon GTT) Neighboring gene proteasome (prosome, macropain) subunit, beta type 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables ubiquitin-protein transferase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in histone H2A-K119 monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H2A-K119 monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within histone acetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in sex chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polycomb group RING finger protein 2
Names
DNA-binding protein Mel-18
melanoma nuclear protein 18
ring finger protein 110
zfp-144
zinc finger protein 144

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163307.1NP_001156779.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_001156779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK142837, BB406926, BI991588, D90085
    Consensus CDS
    CCDS25327.1
    UniProtKB/Swiss-Prot
    P23798
    Related
    ENSMUSP00000137517.2, ENSMUST00000179765.8
    Conserved Domains (3) summary
    PHA03247
    Location:222304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  2. NM_001163308.1NP_001156780.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_001156780.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK142837, BB406926, D90085
    Consensus CDS
    CCDS25327.1
    UniProtKB/Swiss-Prot
    P23798
    Related
    ENSMUSP00000126967.2, ENSMUST00000169807.8
    Conserved Domains (3) summary
    PHA03247
    Location:222304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  3. NM_009545.2NP_033571.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_033571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK142837, BB406926, BB872501, BY008477, D90085
    Consensus CDS
    CCDS25327.1
    UniProtKB/Swiss-Prot
    P23798
    Related
    ENSMUSP00000018681.8, ENSMUST00000018681.14
    Conserved Domains (3) summary
    PHA03247
    Location:222304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97579647..97593260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156633.1XP_036012526.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  2. XM_011248975.3XP_011247277.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011247277.1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  3. XM_011248972.3XP_011247274.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011247274.1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  4. XM_036156632.1XP_036012525.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  5. XM_011248973.3XP_011247275.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011247275.1

    UniProtKB/Swiss-Prot
    P23798
    Conserved Domains (3) summary
    PHA03247
    Location:222304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)