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Mettl15 methyltransferase like 15 [ Mus musculus (house mouse) ]

Gene ID: 76894, updated on 26-Sep-2022

Summary

Official Symbol
Mettl15provided by MGI
Official Full Name
methyltransferase like 15provided by MGI
Primary source
MGI:MGI:1924144
See related
Ensembl:ENSMUSG00000057234 AllianceGenome:MGI:1924144
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mett5d1; 0610027B03Rik
Summary
Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to act upstream of or within methylation. Predicted to be located in mitochondrion. Orthologous to several human genes including METTL15 (methyltransferase like 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 2.5), liver E14 (RPKM 2.3) and 28 other tissues See more
Orthologs
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Genomic context

See Mettl15 in Genome Data Viewer
Location:
2; 2 E3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (108922642..109111678, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (109092297..109281330, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta, pseudogene Neighboring gene predicted gene 13923 Neighboring gene kinesin family member 18A Neighboring gene ribosomal protein L17 pseudogene Neighboring gene brain derived neurotrophic factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC118452

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables rRNA (cytosine-N4-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables rRNA (cytosine-N4-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
12S rRNA N4-methylcytidine methyltransferase
Names
12S rRNA m4C methyltransferase
methyltransferase 5 domain containing 1
methyltransferase 5 domain-containing protein 1
methyltransferase-like protein 15
probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1
probable methyltransferase-like protein 15
putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1
NP_084066.2
XP_006500441.1
XP_006500442.1
XP_036018578.1
XP_036018579.1
XP_036018580.1
XP_036018581.1
XP_036018582.1
XP_036018583.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029790.3NP_084066.2  12S rRNA N4-methylcytidine methyltransferase

    See identical proteins and their annotated locations for NP_084066.2

    Status: PROVISIONAL

    Source sequence(s)
    AL691430, BX813309, BX813328
    Consensus CDS
    CCDS16506.1
    UniProtKB/Swiss-Prot
    Q3KQI4, Q9DCL4
    Related
    ENSMUSP00000080337.4, ENSMUST00000081631.10
    Conserved Domains (1) summary
    PRK00050
    Location:72406
    PRK00050; 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    108922642..109111678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500379.5XP_006500442.1  12S rRNA N4-methylcytidine methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006500442.1

    UniProtKB/Swiss-Prot
    Q3KQI4, Q9DCL4
    Conserved Domains (1) summary
    PRK00050
    Location:72406
    PRK00050; 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH
  2. XM_006500378.3XP_006500441.1  12S rRNA N4-methylcytidine methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006500441.1

    UniProtKB/Swiss-Prot
    Q3KQI4, Q9DCL4
    Conserved Domains (1) summary
    PRK00050
    Location:72406
    PRK00050; 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH
  3. XM_036162689.1XP_036018582.1  12S rRNA N4-methylcytidine methyltransferase isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:8253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. XM_036162688.1XP_036018581.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2312
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. XM_036162690.1XP_036018583.1  12S rRNA N4-methylcytidine methyltransferase isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:8253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. XM_036162685.1XP_036018578.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2312
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. XM_036162686.1XP_036018579.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2312
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  8. XM_036162687.1XP_036018580.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2312
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...