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Mettl15 methyltransferase like 15 [ Mus musculus (house mouse) ]

Gene ID: 76894, updated on 6-Jun-2024

Summary

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Official Symbol
Mettl15provided by MGI
Official Full Name
methyltransferase like 15provided by MGI
Primary source
MGI:MGI:1924144
See related
Ensembl:ENSMUSG00000057234 AllianceGenome:MGI:1924144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mett5d1; 0610027B03Rik
Summary
Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to act upstream of or within methylation. Predicted to be located in mitochondrion. Orthologous to several human genes including METTL15 (methyltransferase like 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 2.5), liver E14 (RPKM 2.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mettl15 in Genome Data Viewer
Location:
2 E3; 2 56.52 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (108922642..109111100, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (109092297..109281330, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta, pseudogene Neighboring gene STARR-seq mESC enhancer starr_05346 Neighboring gene predicted gene 13923 Neighboring gene STARR-seq mESC enhancer starr_05347 Neighboring gene STARR-seq mESC enhancer starr_05348 Neighboring gene STARR-seq mESC enhancer starr_05349 Neighboring gene kinesin family member 18A Neighboring gene STARR-positive B cell enhancer ABC_E5956 Neighboring gene STARR-seq mESC enhancer starr_05353 Neighboring gene STARR-seq mESC enhancer starr_05354 Neighboring gene ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice. Averina OA, et al. Int J Mol Sci, 2022 May 27. PMID 35682734, Free PMC Article
  2. METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue. Laptev I, et al. Nucleic Acids Res, 2020 Aug 20. PMID 32573735, Free PMC Article
  3. Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development. Hurley S, et al. Mol Autism, 2021 Feb 24. PMID 33627187, Free PMC Article
  4. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Favor J, et al. Genetics, 2009 Aug. PMID 19474196, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.
    Title: Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.
  2. METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.
    Title: METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC118452

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (cytosine-N4-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (cytosine-N4-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
12S rRNA N4-methylcytidine methyltransferase
Names
12S rRNA m4C methyltransferase
methyltransferase 5 domain containing 1
methyltransferase 5 domain-containing protein 1
methyltransferase-like protein 15
probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1
probable methyltransferase-like protein 15
putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1
NP_001405755.1
NP_001405756.1
NP_001405757.1
NP_001405758.1
NP_001405759.1
NP_001405760.1
NP_001405761.1
NP_001405762.1
NP_084066.2
XP_036018578.1
XP_036018579.1
XP_036018580.1
XP_036018581.1
XP_036018582.1
XP_036018583.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418826.1 → NP_001405755.1  12S rRNA N4-methylcytidine methyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328
    UniProtKB/Swiss-Prot
    Q3KQI4, Q9DCL4

  2. NM_001418827.1 → NP_001405756.1  12S rRNA N4-methylcytidine methyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328
    UniProtKB/Swiss-Prot
    Q3KQI4, Q9DCL4

  3. NM_001418828.1 → NP_001405757.1  12S rRNA N4-methylcytidine methyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328
    UniProtKB/Swiss-Prot
    Q3KQI4, Q9DCL4

  4. NM_001418829.1 → NP_001405758.1  12S rRNA N4-methylcytidine methyltransferase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328
    UniProtKB/TrEMBL
    A2AGM2
    Related
    ENSMUSP00000116829.2, ENSMUST00000147770.2

  5. NM_001418830.1 → NP_001405759.1  12S rRNA N4-methylcytidine methyltransferase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328
    UniProtKB/TrEMBL
    A2AGM2

  6. NM_001418831.1 → NP_001405760.1  12S rRNA N4-methylcytidine methyltransferase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328
    UniProtKB/TrEMBL
    A2AGM2

  7. NM_001418832.1 → NP_001405761.1  12S rRNA N4-methylcytidine methyltransferase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328
    UniProtKB/TrEMBL
    A2AGM2

  8. NM_001418833.1 → NP_001405762.1  12S rRNA N4-methylcytidine methyltransferase isoform c

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309

  9. NM_029790.4 → NP_084066.2  12S rRNA N4-methylcytidine methyltransferase isoform a

    See identical proteins and their annotated locations for NP_084066.2

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328
    Consensus CDS
    CCDS16506.1
    UniProtKB/Swiss-Prot
    Q3KQI4, Q9DCL4
    Related
    ENSMUSP00000080337.4, ENSMUST00000081631.10
    Conserved Domains (1) summary
    PRK00050
    Location:72 → 406
    PRK00050; 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH

RNA

  1. NR_184831.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328

  2. NR_184832.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328

  3. NR_184833.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328

  4. NR_184834.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL691430, BX813309, BX813328
    Related
    ENSMUST00000147376.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    108922642..109111100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162689.1 → XP_036018582.1  12S rRNA N4-methylcytidine methyltransferase isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:8 → 253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_036162688.1 → XP_036018581.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2 → 312
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_036162690.1 → XP_036018583.1  12S rRNA N4-methylcytidine methyltransferase isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:8 → 253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_036162685.1 → XP_036018578.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2 → 312
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_036162686.1 → XP_036018579.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2 → 312
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. XM_036162687.1 → XP_036018580.1  12S rRNA N4-methylcytidine methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2 → 312
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCL4.2 GenPept UniProtKB/Swiss-Prot:Q9DCL4

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