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METTL15 methyltransferase like 15 [ Homo sapiens (human) ]

Gene ID: 196074, updated on 4-Jul-2021

Summary

Official Symbol
METTL15provided by HGNC
Official Full Name
methyltransferase like 15provided by HGNC
Primary source
HGNC:HGNC:26606
See related
Ensembl:ENSG00000169519 MIM:618711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
METT5D1
Expression
Ubiquitous expression in thyroid (RPKM 2.9), adrenal (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See METTL15 in Genome Data Viewer
Location:
11p14.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (28108251..28527041)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (28129935..28355054)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha family class A member 2, pseudogene Neighboring gene kinesin family member 18A Neighboring gene microRNA 610 Neighboring gene ATP synthase membrane subunit g pseudogene 8 Neighboring gene RN7SK pseudogene 158 Neighboring gene ribosomal protein S15a pseudogene 31 Neighboring gene microRNA 8068 Neighboring gene long intergenic non-protein coding RNA 2758 Neighboring gene uncharacterized LOC105376604 Neighboring gene long intergenic non-protein coding RNA 2742

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33979

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables rRNA (cytosine-N4-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
12S rRNA N4-methylcytidine (m4C) methyltransferase
Names
12S rRNA m4C methyltransferase
methyltransferase 5 domain containing 1
methyltransferase 5 domain-containing protein 1
methyltransferase-like protein 15
probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1
probable methyltransferase-like protein 15
putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1
NP_001107000.1
NP_001284704.1
NP_689849.2
XP_011518237.1
XP_011518242.1
XP_011518243.1
XP_016872786.1
XP_016872789.1
XP_016872790.1
XP_016872792.1
XP_024304148.1
XP_024304149.1
XP_024304150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113528.2NP_001107000.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001107000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC087376, AK091298, AL832668, DB327106, DB458698
    Consensus CDS
    CCDS44559.1
    UniProtKB/Swiss-Prot
    A6NJ78
    Related
    ENSP00000384369.3, ENST00000407364.8
    Conserved Domains (2) summary
    COG0286
    Location:81128
    HsdM; Type I restriction-modification system, DNA methylase subunit [Defense mechanisms]
    PRK00050
    Location:72407
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional
  2. NM_001297775.2NP_001284704.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform 3

    See identical proteins and their annotated locations for NP_001284704.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC023206, AC087376, AC104978, BC066900, DA800481
    Consensus CDS
    CCDS73269.1
    UniProtKB/Swiss-Prot
    A6NJ78
    Related
    ENSP00000385507.3, ENST00000406787.7
    Conserved Domains (2) summary
    COG0286
    Location:81128
    HsdM; Type I restriction-modification system, DNA methylase subunit [Defense mechanisms]
    cl17173
    Location:67197
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_152636.3NP_689849.2  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_689849.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 3' coding region, compared to variant 1, one of which results in a premature termination codon. The encoded protein (isoform 2) has a novel shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC087376, AK091298, AL832668, DB327106, DB458698
    Consensus CDS
    CCDS31450.1
    UniProtKB/Swiss-Prot
    A6NJ78
    Related
    ENSP00000307251.6, ENST00000303459.10
    Conserved Domains (2) summary
    COG0286
    Location:81128
    HsdM; Type I restriction-modification system, DNA methylase subunit [Defense mechanisms]
    cl17173
    Location:72260
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    28108251..28527041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519941.2XP_011518243.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X7

    Conserved Domains (2) summary
    COG0286
    Location:81128
    HsdM; Type I restriction-modification system, DNA methylase subunit [Defense mechanisms]
    cl17173
    Location:72129
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_011519935.3XP_011518237.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X2

    See identical proteins and their annotated locations for XP_011518237.1

    Conserved Domains (1) summary
    PRK00050
    Location:24342
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional
  3. XM_024448381.1XP_024304149.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X2

    Conserved Domains (1) summary
    PRK00050
    Location:24342
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional
  4. XM_024448382.1XP_024304150.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:5266
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. XM_017017303.2XP_016872792.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:5266
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. XM_011519940.3XP_011518242.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X6

    Conserved Domains (2) summary
    COG0286
    Location:81128
    HsdM; Type I restriction-modification system, DNA methylase subunit [Defense mechanisms]
    cl17173
    Location:67203
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. XM_017017301.2XP_016872790.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X4

    Related
    ENSP00000489381.1, ENST00000634627.1
  8. XM_017017297.2XP_016872786.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    A6NJ78
    Conserved Domains (2) summary
    COG0286
    Location:81128
    HsdM; Type I restriction-modification system, DNA methylase subunit [Defense mechanisms]
    PRK00050
    Location:72407
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional
  9. XM_024448380.1XP_024304148.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X2

    Conserved Domains (1) summary
    PRK00050
    Location:24342
    PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional
  10. XM_017017300.2XP_016872789.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X3

RNA

  1. XR_930849.2 RNA Sequence

  2. XR_001747787.1 RNA Sequence

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