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Fam81a family with sequence similarity 81, member A [ Mus musculus (house mouse) ]

Gene ID: 76886, updated on 2-Nov-2024

Summary

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Official Symbol
Fam81aprovided by MGI
Official Full Name
family with sequence similarity 81, member Aprovided by MGI
Primary source
MGI:MGI:1924136
See related
Ensembl:ENSMUSG00000032224 AllianceGenome:MGI:1924136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6430514L14Rik
Summary
Enables molecular condensate scaffold activity. Located in postsynaptic density. Is expressed in brain; jaw bone; nasal epithelium; trigeminal ganglion; and vibrissa. Orthologous to human FAM81A (family with sequence similarity 81 member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 31.1), frontal lobe adult (RPKM 29.8) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Fam81a in Genome Data Viewer
Location:
9 D; 9 39.27 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69996586..70049840, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70089304..70142558, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24529 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene STARR-seq mESC enhancer starr_24532 Neighboring gene STARR-seq mESC enhancer starr_24534 Neighboring gene predicted gene, 39369 Neighboring gene predicted gene, 39476 Neighboring gene predicted gene, 24257 Neighboring gene STARR-positive B cell enhancer ABC_E1389 Neighboring gene predicted gene, 26849 Neighboring gene STARR-positive B cell enhancer ABC_E5083 Neighboring gene myosin IE

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina. Banerjee S, et al. Front Cell Neurosci, 2020. PMID 32547367, Free PMC Article
  2. FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. Kaizuka T, et al. PLoS Biol, 2024 Mar. PMID 38452102, Free PMC Article
  3. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Ling KH, et al. Genome Biol, 2009. PMID 19799774, Free PMC Article
  4. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
  5. Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Li J, et al. Sci Signal, 2016 Aug 9. PMID 27507650

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM81A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433743.1 → NP_001420672.1  protein FAM81A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157950

  2. NM_001433744.1 → NP_001420673.1  protein FAM81A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157950

  3. NM_001433745.1 → NP_001420674.1  protein FAM81A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157950

  4. NM_001433746.1 → NP_001420675.1  protein FAM81A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157950

  5. NM_001433747.1 → NP_001420676.1  protein FAM81A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157950

  6. NM_029784.3 → NP_084060.1  protein FAM81A isoform 1

    See identical proteins and their annotated locations for NP_084060.1

    Status: VALIDATED

    Source sequence(s)
    AC157950
    Consensus CDS
    CCDS40679.1
    UniProtKB/Swiss-Prot
    Q3UXZ6, Q8BQV1, Q8C548, Q8R3B5, Q9D369
    Related
    ENSMUSP00000034749.9, ENSMUST00000034749.16
    Conserved Domains (1) summary
    COG1196
    Location:76 → 317
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    69996586..70049840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244712.1 → XP_030100572.1  protein FAM81A isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:68 → 309
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_006511551.4 → XP_006511614.1  protein FAM81A isoform X1

    UniProtKB/Swiss-Prot
    Q3UXZ6, Q8BQV1, Q8C548, Q8R3B5, Q9D369
    Conserved Domains (1) summary
    COG1196
    Location:76 → 317
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006511550.5 → XP_006511613.1  protein FAM81A isoform X1

    UniProtKB/Swiss-Prot
    Q3UXZ6, Q8BQV1, Q8C548, Q8R3B5, Q9D369
    Conserved Domains (1) summary
    COG1196
    Location:76 → 317
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UXZ6.2 GenPept UniProtKB/Swiss-Prot:Q3UXZ6

Gene LinkOut

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