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FAM81A family with sequence similarity 81 member A [ Homo sapiens (human) ]

Gene ID: 145773, updated on 22-Sep-2022

Summary

Official Symbol
FAM81Aprovided by HGNC
Official Full Name
family with sequence similarity 81 member Aprovided by HGNC
Primary source
HGNC:HGNC:28379
See related
Ensembl:ENSG00000157470 AllianceGenome:HGNC:28379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 9.6), kidney (RPKM 2.3) and 7 other tissues See more
Orthologs
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Genomic context

See FAM81A in Genome Data Viewer
Location:
15q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (59397981..59523555)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (57239916..57325275)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59730385..59815754)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene myosin IE Neighboring gene RNA, U6 small nuclear 212, pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein L7a pseudogene 75 Neighboring gene NSA2 pseudogene 4 Neighboring gene ribosomal protein L21 pseudogene 114 Neighboring gene ribosomal protein L21 pseudogene 117 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26690

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152450.3NP_689663.2  protein FAM81A

    See identical proteins and their annotated locations for NP_689663.2

    Status: VALIDATED

    Source sequence(s)
    AC091748, AC092754, BC022537
    Consensus CDS
    CCDS45269.1
    UniProtKB/Swiss-Prot
    Q8TBF8
    Related
    ENSP00000288228.5, ENST00000288228.10
    Conserved Domains (1) summary
    COG1196
    Location:79334
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    59397981..59523555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432171.1XP_047288127.1  protein FAM81A isoform X2

    UniProtKB/Swiss-Prot
    Q8TBF8
  2. XM_047432170.1XP_047288126.1  protein FAM81A isoform X2

    UniProtKB/Swiss-Prot
    Q8TBF8
  3. XM_011521248.3XP_011519550.1  protein FAM81A isoform X1

    See identical proteins and their annotated locations for XP_011519550.1

    Conserved Domains (1) summary
    COG1196
    Location:88343
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  4. XM_024449846.2XP_024305614.1  protein FAM81A isoform X2

    UniProtKB/Swiss-Prot
    Q8TBF8
    Conserved Domains (1) summary
    COG1196
    Location:79334
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  5. XM_006720398.4XP_006720461.1  protein FAM81A isoform X2

    See identical proteins and their annotated locations for XP_006720461.1

    UniProtKB/Swiss-Prot
    Q8TBF8
    Conserved Domains (1) summary
    COG1196
    Location:79334
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  6. XM_011521247.3XP_011519549.1  protein FAM81A isoform X1

    See identical proteins and their annotated locations for XP_011519549.1

    Conserved Domains (1) summary
    COG1196
    Location:88343
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  7. XM_011521250.3XP_011519552.1  protein FAM81A isoform X2

    See identical proteins and their annotated locations for XP_011519552.1

    UniProtKB/Swiss-Prot
    Q8TBF8
    Conserved Domains (1) summary
    COG1196
    Location:79334
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  8. XM_047432168.1XP_047288124.1  protein FAM81A isoform X1

  9. XM_011521249.3XP_011519551.1  protein FAM81A isoform X2

    See identical proteins and their annotated locations for XP_011519551.1

    UniProtKB/Swiss-Prot
    Q8TBF8
    Conserved Domains (1) summary
    COG1196
    Location:79334
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  10. XM_047432169.1XP_047288125.1  protein FAM81A isoform X1

  11. XM_005254166.3XP_005254223.1  protein FAM81A isoform X1

    See identical proteins and their annotated locations for XP_005254223.1

    Conserved Domains (1) summary
    COG1196
    Location:88343
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  12. XM_017021932.2XP_016877421.1  protein FAM81A isoform X1

    Conserved Domains (1) summary
    COG1196
    Location:88343
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  13. XM_017021931.2XP_016877420.1  protein FAM81A isoform X1

    Conserved Domains (1) summary
    COG1196
    Location:88343
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    57239916..57325275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)