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Mettl4 methyltransferase 4, N6-adenosine [ Mus musculus (house mouse) ]

Gene ID: 76781, updated on 27-Nov-2024

Summary

Official Symbol
Mettl4provided by MGI
Official Full Name
methyltransferase 4, N6-adenosineprovided by MGI
Primary source
MGI:MGI:1924031
See related
Ensembl:ENSMUSG00000055660 AllianceGenome:MGI:1924031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HsT661; 2410198H06Rik; A730091E08Rik
Summary
Enables site-specific DNA-methyltransferase (adenine-specific) activity. Involved in negative regulation of gene expression, epigenetic. Predicted to be located in mitochondrial matrix. Predicted to be active in cytosol and nucleus. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 3.7), CNS E11.5 (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See Mettl4 in Genome Data Viewer
Location:
17 E5; 17 61.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (95030018..95057579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (94722590..94750214, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9416 Neighboring gene STARR-seq mESC enhancer starr_43640 Neighboring gene predicted gene, 41655 Neighboring gene STARR-seq mESC enhancer starr_43642 Neighboring gene STARR-seq mESC enhancer starr_43643 Neighboring gene STARR-seq mESC enhancer starr_43644 Neighboring gene NDC80 homolog, kinetochore complex component pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr17:95148921-95149221 Neighboring gene STARR-positive B cell enhancer mm9_chr17:95149244-95149545 Neighboring gene STARR-positive B cell enhancer ABC_E8926 Neighboring gene predicted gene 1976 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 7 Neighboring gene STARR-positive B cell enhancer mm9_chr17:95233967-95234268 Neighboring gene STARR-positive B cell enhancer mm9_chr17:95235804-95236104 Neighboring gene signal recognition particle 19 kDa protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables site-specific DNA-methyltransferase (adenine-specific) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables site-specific DNA-methyltransferase (adenine-specific) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in snRNA (adenine-N6)-methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in snRNA (adenine-N6)-methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
N(6)-adenine-specific methyltransferase METTL4
Names
N(6)-adenine-specific DNA methyltransferase METTL4
methyltransferase like 4
methyltransferase-like protein 4
snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4
NP_001344064.1
NP_001344065.1
NP_001344066.1
NP_001344067.1
NP_795891.2
XP_011245012.1
XP_036016723.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357135.2NP_001344064.1  N(6)-adenine-specific methyltransferase METTL4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS29030.1
    UniProtKB/Swiss-Prot
    Q3U034
    Conserved Domains (1) summary
    cl01947
    Location:280454
    MT-A70
  2. NM_001357136.2NP_001344065.1  N(6)-adenine-specific methyltransferase METTL4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS29030.1
    UniProtKB/Swiss-Prot
    Q3U034
    Conserved Domains (1) summary
    cl01947
    Location:280454
    MT-A70
  3. NM_001357137.2NP_001344066.1  N(6)-adenine-specific methyltransferase METTL4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS89172.1
    UniProtKB/TrEMBL
    A4FTY8
    Related
    ENSMUSP00000127142.3, ENSMUST00000171284.3
    Conserved Domains (1) summary
    cl01947
    Location:259433
    MT-A70
  4. NM_001357138.2NP_001344067.1  N(6)-adenine-specific methyltransferase METTL4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS89172.1
    UniProtKB/TrEMBL
    A4FTY8
    Conserved Domains (1) summary
    cl01947
    Location:259433
    MT-A70
  5. NM_176917.6NP_795891.2  N(6)-adenine-specific methyltransferase METTL4 isoform 1

    See identical proteins and their annotated locations for NP_795891.2

    Status: VALIDATED

    Source sequence(s)
    AC165075
    Consensus CDS
    CCDS29030.1
    UniProtKB/Swiss-Prot
    Q3U034
    Related
    ENSMUSP00000157180.2, ENSMUST00000234990.2
    Conserved Domains (1) summary
    cl01947
    Location:280454
    MT-A70

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    95030018..95057579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160830.1XP_036016723.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

    Conserved Domains (1) summary
    cl01947
    Location:259401
    MT-A70
  2. XM_011246710.3XP_011245012.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

    Conserved Domains (1) summary
    cl01947
    Location:280422
    MT-A70

RNA

  1. XR_001782127.3 RNA Sequence