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METTL4 methyltransferase 4, N6-adenosine [ Homo sapiens (human) ]

Gene ID: 64863, updated on 8-Dec-2022

Summary

Official Symbol
METTL4provided by HGNC
Official Full Name
methyltransferase 4, N6-adenosineprovided by HGNC
Primary source
HGNC:HGNC:24726
See related
Ensembl:ENSG00000101574 MIM:619626; AllianceGenome:HGNC:24726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT661
Summary
Enables RNA methyltransferase activity and site-specific DNA-methyltransferase (adenine-specific) activity. Involved in nucleic acid metabolic process; regulation of RNA metabolic process; and regulation of mitochondrial DNA replication. Located in cytosol; mitochondrial matrix; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 4.0), thyroid (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

See METTL4 in Genome Data Viewer
Location:
18p11.32
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (2537530..2571505, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (2693282..2727252, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (2537529..2571504, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371961 Neighboring gene uncharacterized LOC124904235 Neighboring gene small nucleolar RNA U109 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like Neighboring gene NDC80 kinetochore complex component Neighboring gene katanin regulatory subunit B1 like 1 pseudogene 3 Neighboring gene RNA, U6 small nuclear 340, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
EBI GWAS Catalog

General gene information

Markers

Homology

Clone Names

  • FLJ23017, MGC117235

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA methylation on adenine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA methylation on adenine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in snRNA (adenine-N6)-methylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N(6)-adenine-specific methyltransferase METTL4
Names
N(6)-adenine-specific DNA methyltransferase METTL4
methyltransferase like 4
methyltransferase-like protein 4
snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4
NP_001295330.1
NP_073751.3
XP_005258189.1
XP_005258190.1
XP_011524032.1
XP_047293697.1
XP_047293698.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308401.2NP_001295330.1  N(6)-adenine-specific methyltransferase METTL4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AP005136
    Consensus CDS
    CCDS77144.1
    UniProtKB/TrEMBL
    J3KNJ7
    Related
    ENSP00000320349.6, ENST00000319888.10
    Conserved Domains (1) summary
    cl01947
    Location:281383
    MT-A70
  2. NM_022840.5NP_073751.3  N(6)-adenine-specific methyltransferase METTL4 isoform 1

    See identical proteins and their annotated locations for NP_073751.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP005136, BC111020, BU741018, HY026088
    Consensus CDS
    CCDS11826.1
    UniProtKB/Swiss-Prot
    Q8N3J2, Q9H5U9
    Related
    ENSP00000458290.1, ENST00000574538.2
    Conserved Domains (1) summary
    cl01947
    Location:281455
    MT-A70

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    2537530..2571505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258133.4XP_005258190.1  N(6)-adenine-specific methyltransferase METTL4 isoform X4

    Conserved Domains (1) summary
    cl01947
    Location:134308
    MT-A70
  2. XM_011525730.4XP_011524032.1  N(6)-adenine-specific methyltransferase METTL4 isoform X3

    Conserved Domains (1) summary
    cl01947
    Location:281300
    MT-A70
  3. XM_005258132.5XP_005258189.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

    Conserved Domains (1) summary
    cl01947
    Location:281358
    MT-A70
  4. XM_047437741.1XP_047293697.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

  5. XM_047437742.1XP_047293698.1  N(6)-adenine-specific methyltransferase METTL4 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    2693282..2727252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)