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Immt inner membrane protein, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 76614, updated on 5-Jan-2023

Summary

Official Symbol
Immtprovided by MGI
Official Full Name
inner membrane protein, mitochondrialprovided by MGI
Primary source
MGI:MGI:1923864
See related
Ensembl:ENSMUSG00000052337 AllianceGenome:MGI:1923864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HMP; P87; P89; P87/89; Micos60; 1700082C19Rik; D830041H16Rik
Summary
Acts upstream of or within mitochondrial calcium ion homeostasis. Located in mitochondrial intermembrane space. Is expressed in several structures, including alimentary system; cranial ganglion; lung; medulla oblongata basal plate mantle layer; and seminiferous cord. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 50.7), placenta adult (RPKM 32.4) and 28 other tissues See more
Orthologs
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Genomic context

See Immt in Genome Data Viewer
Location:
6; 6 C1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71806200..71852250)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71831091..71875266)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 1 Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene polymerase (RNA) I polypeptide A Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrial calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
MICOS complex subunit Mic60
Names
mitochondrial inner membrane protein
mitofilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253681.1NP_001240610.1  MICOS complex subunit Mic60 isoform 2

    See identical proteins and their annotated locations for NP_001240610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' coding region compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK049189, BU754623, CJ058627
    Consensus CDS
    CCDS57425.1
    UniProtKB/Swiss-Prot
    Q8CAQ8
    Related
    ENSMUSP00000098859.4, ENSMUST00000101301.10
    Conserved Domains (1) summary
    pfam09731
    Location:43734
    Mitofilin; Mitochondrial inner membrane protein
  2. NM_001253686.1NP_001240615.1  MICOS complex subunit Mic60 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 5' coding region and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK152588, AK159909, BU754623, CJ058627
    UniProtKB/TrEMBL
    Q3TVZ5, Q3U7N2
    Conserved Domains (1) summary
    pfam09731
    Location:43729
    Mitofilin; Mitochondrial inner membrane protein
  3. NM_001253687.1NP_001240616.1  MICOS complex subunit Mic60 isoform 4

    See identical proteins and their annotated locations for NP_001240616.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction in the 5' coding region and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK033126, BU754623, CJ058627
    Consensus CDS
    CCDS57426.1
    UniProtKB/Swiss-Prot
    Q8CAQ8
    Related
    ENSMUSP00000109788.4, ENSMUST00000114151.10
    Conserved Domains (1) summary
    pfam09731
    Location:43697
    Mitofilin; Mitochondrial inner membrane protein
  4. NM_001253688.1NP_001240617.1  MICOS complex subunit Mic60 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK038129, AK169365, BU754623, CJ058627
    Consensus CDS
    CCDS57428.1
    UniProtKB/Swiss-Prot
    Q8CAQ8
    UniProtKB/TrEMBL
    E9Q800, Q3TEY5
    Related
    ENSMUSP00000128967.2, ENSMUST00000166938.8
    Conserved Domains (1) summary
    pfam09731
    Location:43667
    Mitofilin; Mitochondrial inner membrane protein
  5. NM_001253689.1NP_001240618.1  MICOS complex subunit Mic60 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate in-frame exons and uses an alternate splice junction in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (6) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK146640, BU754623, CJ058627
    Consensus CDS
    CCDS57427.1
    UniProtKB/TrEMBL
    E9QAY6
    Related
    ENSMUSP00000128367.2, ENSMUST00000166975.8
    Conserved Domains (1) summary
    pfam09731
    Location:43466
    Mitofilin; Mitochondrial inner membrane protein
  6. NM_001362134.1NP_001349063.1  MICOS complex subunit Mic60 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC122200
    Conserved Domains (1) summary
    pfam09731
    Location:43708
    Mitofilin; Mitochondrial inner membrane protein
  7. NM_001362136.1NP_001349065.1  MICOS complex subunit Mic60 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) usess an alternate in-frame splice junction in the 5' coding region compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC122200
    Conserved Domains (1) summary
    pfam09731
    Location:43733
    Mitofilin; Mitochondrial inner membrane protein
  8. NM_001362137.1NP_001349066.1  MICOS complex subunit Mic60 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC122200
    Conserved Domains (1) summary
    pfam09731
    Location:43713
    Mitofilin; Mitochondrial inner membrane protein
  9. NM_001362138.1NP_001349067.1  MICOS complex subunit Mic60 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) uses an alternate in-frame splice junction in the 5' coding region and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC122200
    Conserved Domains (1) summary
    pfam09731
    Location:43702
    Mitofilin; Mitochondrial inner membrane protein
  10. NM_029673.3NP_083949.2  MICOS complex subunit Mic60 isoform 1

    See identical proteins and their annotated locations for NP_083949.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK038129, BU754623, CJ058627
    Consensus CDS
    CCDS39509.1
    UniProtKB/Swiss-Prot
    Q8CAQ8, Q9D9F6
    Related
    ENSMUSP00000066181.7, ENSMUST00000064062.13
    Conserved Domains (1) summary
    pfam09731
    Location:43745
    Mitofilin; Mitochondrial inner membrane protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71806200..71852250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321823.3XP_017177312.1  MICOS complex subunit Mic60 isoform X1

    Conserved Domains (1) summary
    pfam09731
    Location:43740
    Mitofilin; Mitochondrial inner membrane protein
  2. XM_030255663.2XP_030111523.1  MICOS complex subunit Mic60 isoform X2

    Conserved Domains (1) summary
    pfam09731
    Location:43728
    Mitofilin; Mitochondrial inner membrane protein
  3. XM_017321828.3XP_017177317.1  MICOS complex subunit Mic60 isoform X3

    Conserved Domains (1) summary
    pfam09731
    Location:43701
    Mitofilin; Mitochondrial inner membrane protein
  4. XM_030255664.2XP_030111524.1  MICOS complex subunit Mic60 isoform X4

    Conserved Domains (1) summary
    pfam09731
    Location:43696
    Mitofilin; Mitochondrial inner membrane protein
  5. XM_030255665.2XP_030111525.1  MICOS complex subunit Mic60 isoform X5

    Conserved Domains (1) summary
    pfam09731
    Location:43662
    Mitofilin; Mitochondrial inner membrane protein