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IMMT inner membrane mitochondrial protein [ Homo sapiens (human) ]

Gene ID: 10989, updated on 4-Dec-2022

Summary

Official Symbol
IMMTprovided by HGNC
Official Full Name
inner membrane mitochondrial proteinprovided by HGNC
Primary source
HGNC:HGNC:6047
See related
Ensembl:ENSG00000132305 MIM:600378; AllianceGenome:HGNC:6047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMP; P87; P89; PIG4; Mic60; PIG52; MINOS2; P87/89; MICOS60
Summary
Enables RNA binding activity. Involved in cristae formation. Located in mitochondrial inner membrane. Part of MICOS complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 51.0), adrenal (RPKM 34.2) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See IMMT in Genome Data Viewer
Location:
2p11.2; 2
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (86143936..86195462, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (86146002..86197566, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (86371059..86422585, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene Sharpr-MPRA regulatory region 1812 Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene microRNA 4779 Neighboring gene Sharpr-MPRA regulatory region 10968 Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene receptor accessory protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111146, DKFZp779P1653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cristae formation IC
Inferred by Curator
more info
PubMed 
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner mitochondrial membrane organization IC
Inferred by Curator
more info
PubMed 
involved_in mitochondrial calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MICOS complex subunit MIC60
Names
cell proliferation-inducing gene 4/52 protein
cell proliferation-inducing protein 52
heart muscle protein
mitochondrial contact site and cristae organizing system subunit 60
mitochondrial inner membrane organizing system 2
mitochondrial inner membrane protein
mitofilin
motor protein
proliferation-inducing gene 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100169.2NP_001093639.1  MICOS complex subunit MIC60 isoform 2

    See identical proteins and their annotated locations for NP_001093639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in a protein (isoform 2) that is shorter than isoform 1.
    Source sequence(s)
    AY232292, BC027458, DC403234
    Consensus CDS
    CCDS46356.1
    UniProtKB/Swiss-Prot
    Q16891
    Related
    ENSP00000407788.2, ENST00000442664.6
    Conserved Domains (1) summary
    pfam09731
    Location:44745
    Mitofilin; Mitochondrial inner membrane protein
  2. NM_001100170.2NP_001093640.1  MICOS complex subunit MIC60 isoform 3

    See identical proteins and their annotated locations for NP_001093640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in a protein (isoform 3) that is shorter than isoform 1.
    Source sequence(s)
    AK225780, BC002412, BC027458, DC403234
    Consensus CDS
    CCDS46357.1
    UniProtKB/Swiss-Prot
    Q16891
    Related
    ENSP00000396899.2, ENST00000449247.6
    Conserved Domains (1) summary
    pfam09731
    Location:44735
    Mitofilin; Mitochondrial inner membrane protein
  3. NM_001400086.1NP_001387015.1  MICOS complex subunit MIC60 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009309
  4. NM_001400087.1NP_001387016.1  MICOS complex subunit MIC60 isoform 42

    Status: VALIDATED

    Source sequence(s)
    AC009309
  5. NM_001400088.1NP_001387017.1  MICOS complex subunit MIC60 isoform 43

    Status: VALIDATED

    Source sequence(s)
    AC009309
  6. NM_001400089.1NP_001387018.1  MICOS complex subunit MIC60 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC009309
  7. NM_001400090.1NP_001387019.1  MICOS complex subunit MIC60 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC009309
  8. NM_001400091.1NP_001387020.1  MICOS complex subunit MIC60 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC009309
  9. NM_001400100.1NP_001387029.1  MICOS complex subunit MIC60 isoform 44

    Status: VALIDATED

    Source sequence(s)
    AC009309
  10. NM_001400101.1NP_001387030.1  MICOS complex subunit MIC60 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC009309
  11. NM_001400102.1NP_001387031.1  MICOS complex subunit MIC60 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC009309
  12. NM_001400103.1NP_001387032.1  MICOS complex subunit MIC60 isoform 45

    Status: VALIDATED

    Source sequence(s)
    AC009309
  13. NM_001400104.1NP_001387033.1  MICOS complex subunit MIC60 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC009309
    Related
    ENSP00000387227.2, ENST00000409051.6
  14. NM_001400105.1NP_001387034.1  MICOS complex subunit MIC60 isoform 38

    Status: VALIDATED

    Source sequence(s)
    AC009309
  15. NM_001400106.1NP_001387035.1  MICOS complex subunit MIC60 isoform 39

    Status: VALIDATED

    Source sequence(s)
    AC009309
  16. NM_001400107.1NP_001387036.1  MICOS complex subunit MIC60 isoform 40

    Status: VALIDATED

    Source sequence(s)
    AC009309
  17. NM_001400108.1NP_001387037.1  MICOS complex subunit MIC60 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC009309
  18. NM_001400109.1NP_001387038.1  MICOS complex subunit MIC60 isoform 41

    Status: VALIDATED

    Source sequence(s)
    AC009309
  19. NM_001400110.1NP_001387039.1  MICOS complex subunit MIC60 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC009309
  20. NM_001400111.1NP_001387040.1  MICOS complex subunit MIC60 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC009309
  21. NM_001400112.1NP_001387041.1  MICOS complex subunit MIC60 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC009309
  22. NM_001400113.1NP_001387042.1  MICOS complex subunit MIC60 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC009309
  23. NM_001400114.1NP_001387043.1  MICOS complex subunit MIC60 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC009309
  24. NM_001400115.1NP_001387044.1  MICOS complex subunit MIC60 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC009309
  25. NM_001400116.1NP_001387045.1  MICOS complex subunit MIC60 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC009309
  26. NM_001400117.1NP_001387046.1  MICOS complex subunit MIC60 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC009309
    UniProtKB/TrEMBL
    B4DS66
    Related
    ENSP00000415762.2, ENST00000419070.6
  27. NM_001400118.1NP_001387047.1  MICOS complex subunit MIC60 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC009309
    UniProtKB/TrEMBL
    B4DS66
  28. NM_001400119.1NP_001387048.1  MICOS complex subunit MIC60 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC009309
  29. NM_001400120.1NP_001387049.1  MICOS complex subunit MIC60 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC009309
  30. NM_001400121.1NP_001387050.1  MICOS complex subunit MIC60 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC009309
  31. NM_001400122.1NP_001387051.1  MICOS complex subunit MIC60 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC009309
  32. NM_001400123.1NP_001387052.1  MICOS complex subunit MIC60 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC009309
  33. NM_001400124.1NP_001387053.1  MICOS complex subunit MIC60 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC009309
  34. NM_001400125.1NP_001387054.1  MICOS complex subunit MIC60 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC009309
  35. NM_001400126.1NP_001387055.1  MICOS complex subunit MIC60 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC009309
  36. NM_001400127.1NP_001387056.1  MICOS complex subunit MIC60 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC009309
  37. NM_001400128.1NP_001387057.1  MICOS complex subunit MIC60 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC009309
  38. NM_001400129.1NP_001387058.1  MICOS complex subunit MIC60 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC009309
  39. NM_001400130.1NP_001387059.1  MICOS complex subunit MIC60 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC009309
  40. NM_001400131.1NP_001387060.1  MICOS complex subunit MIC60 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC009309
  41. NM_001400132.1NP_001387061.1  MICOS complex subunit MIC60 isoform 27

    Status: VALIDATED

    Source sequence(s)
    AC009309
    Related
    ENST00000474969.5
  42. NM_001400133.1NP_001387062.1  MICOS complex subunit MIC60 isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC009309
  43. NM_001400134.1NP_001387063.1  MICOS complex subunit MIC60 isoform 29

    Status: VALIDATED

    Source sequence(s)
    AC009309
  44. NM_001400135.1NP_001387064.1  MICOS complex subunit MIC60 isoform 30

    Status: VALIDATED

    Source sequence(s)
    AC009309
  45. NM_001400137.1NP_001387066.1  MICOS complex subunit MIC60 isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC009309
    Consensus CDS
    CCDS92794.1
    UniProtKB/TrEMBL
    C9J406
    Related
    ENSP00000254636.5, ENST00000254636.9
  46. NM_001400138.1NP_001387067.1  MICOS complex subunit MIC60 isoform 32

    Status: VALIDATED

    Source sequence(s)
    AC009309
  47. NM_001400140.1NP_001387069.1  MICOS complex subunit MIC60 isoform 33

    Status: VALIDATED

    Source sequence(s)
    AC009309
  48. NM_001400142.1NP_001387071.1  MICOS complex subunit MIC60 isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC009309
  49. NM_001400143.1NP_001387072.1  MICOS complex subunit MIC60 isoform 35

    Status: VALIDATED

    Source sequence(s)
    AC009309
  50. NM_001400144.1NP_001387073.1  MICOS complex subunit MIC60 isoform 36

    Status: VALIDATED

    Source sequence(s)
    AC009309
  51. NM_001400145.1NP_001387074.1  MICOS complex subunit MIC60 isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC009309
  52. NM_006839.3NP_006830.2  MICOS complex subunit MIC60 isoform 1

    See identical proteins and their annotated locations for NP_006830.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC002412, BC027458, DC403234
    Consensus CDS
    CCDS46355.1
    UniProtKB/Swiss-Prot
    Q16891, Q9P0V2
    Related
    ENSP00000387262.3, ENST00000410111.8
    Conserved Domains (1) summary
    pfam09731
    Location:44746
    Mitofilin; Mitochondrial inner membrane protein

RNA

  1. NR_174393.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309
  2. NR_174394.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309
  3. NR_174395.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309
  4. NR_174396.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309
  5. NR_174397.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309
  6. NR_174398.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309
  7. NR_174399.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309
  8. NR_174400.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309
  9. NR_174401.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309
  10. NR_174402.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009309

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    86143936..86195462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    86146002..86197566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)