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Celf6 CUGBP, Elav-like family member 6 [ Mus musculus (house mouse) ]

Gene ID: 76183, updated on 18-Apr-2024

Summary

Official Symbol
Celf6provided by MGI
Official Full Name
CUGBP, Elav-like family member 6provided by MGI
Primary source
MGI:MGI:1923433
See related
Ensembl:ENSMUSG00000032297 AllianceGenome:MGI:1923433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brunol6; 6330569O16Rik
Summary
Predicted to enable mRNA binding activity. Acts upstream of or within serotonergic synaptic transmission and vocalization behavior. Located in cytoplasm. Is expressed in several structures, including brain; spinal cord; stomach; testis; and trigeminal ganglion. Orthologous to human CELF6 (CUGBP Elav-like family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 4.7), testis adult (RPKM 3.2) and 8 other tissues See more
Orthologs
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Genomic context

Location:
9 B; 9 32.02 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59485587..59516316)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59578287..59609033)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33180 Neighboring gene transmembrane protein 202 Neighboring gene hexosaminidase A Neighboring gene predicted gene, 51709 Neighboring gene STARR-positive B cell enhancer ABC_E8292 Neighboring gene poly (ADP-ribose) polymerase family, member 6 Neighboring gene predicted gene, 51708 Neighboring gene STARR-seq mESC enhancer starr_24306 Neighboring gene STARR-positive B cell enhancer ABC_E1115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:59507567-59507768 Neighboring gene uncharacterized LOC115487221 Neighboring gene pyruvate kinase, muscle

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
CUGBP Elav-like family member 6
Names
CUG-BP- and ETR-3-like factor 6
RNA-binding protein BRUNOL-6
bruno-like 6, RNA binding protein
bruno-like protein 6
NP_001298021.1
NP_001348028.1
NP_001400450.1
NP_001400451.1
NP_001400452.1
NP_001400453.1
NP_001400454.1
NP_001400455.1
NP_001400456.1
NP_001400457.1
NP_780444.2
XP_006511606.1
XP_006511608.1
XP_011241136.1
XP_017169170.1
XP_036011268.1
XP_036011269.1
XP_036011270.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311092.3NP_001298021.1  CUGBP Elav-like family member 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123817
    Consensus CDS
    CCDS81012.1
    UniProtKB/TrEMBL
    D3YX51
    Related
    ENSMUSP00000112403.2, ENSMUST00000118164.3
    Conserved Domains (3) summary
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:255333
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl25887
    Location:32256
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. NM_001361099.2NP_001348028.1  CUGBP Elav-like family member 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123817
    Consensus CDS
    CCDS90585.1
    Related
    ENSMUSP00000113196.2, ENSMUST00000121266.8
    Conserved Domains (3) summary
    TIGR01628
    Location:32257
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:256334
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  3. NM_001413521.1NP_001400450.1  CUGBP Elav-like family member 6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123817
    UniProtKB/TrEMBL
    D3YU11
    Related
    ENSMUSP00000112755.2, ENSMUST00000118549.8
  4. NM_001413522.1NP_001400451.1  CUGBP Elav-like family member 6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123817
  5. NM_001413523.1NP_001400452.1  CUGBP Elav-like family member 6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123817
  6. NM_001413524.1NP_001400453.1  CUGBP Elav-like family member 6 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC123817
  7. NM_001413525.1NP_001400454.1  CUGBP Elav-like family member 6 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC123817
  8. NM_001413526.1NP_001400455.1  CUGBP Elav-like family member 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123817
  9. NM_001413527.1NP_001400456.1  CUGBP Elav-like family member 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123817
  10. NM_001413528.1NP_001400457.1  CUGBP Elav-like family member 6 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC123817
  11. NM_175235.4NP_780444.2  CUGBP Elav-like family member 6 isoform 1

    See identical proteins and their annotated locations for NP_780444.2

    Status: VALIDATED

    Source sequence(s)
    AC123817
    Consensus CDS
    CCDS23251.1
    UniProtKB/Swiss-Prot
    Q7TN33, Q8BJ35
    Related
    ENSMUSP00000034840.4, ENSMUST00000034840.10
    Conserved Domains (4) summary
    cd12632
    Location:41127
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:133213
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:371449
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01659
    Location:295457
    sex-lethal; sex-lethal family splicing factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    59485587..59516316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155375.1XP_036011268.1  CUGBP Elav-like family member 6 isoform X4

    Conserved Domains (3) summary
    TIGR01628
    Location:32275
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:277355
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  2. XM_036155376.1XP_036011269.1  CUGBP Elav-like family member 6 isoform X5

    Conserved Domains (3) summary
    TIGR01628
    Location:32257
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:256334
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  3. XM_036155377.1XP_036011270.1  CUGBP Elav-like family member 6 isoform X5

    Conserved Domains (3) summary
    TIGR01628
    Location:32257
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:256334
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  4. XM_006511545.2XP_006511608.1  CUGBP Elav-like family member 6 isoform X4

    See identical proteins and their annotated locations for XP_006511608.1

    Conserved Domains (3) summary
    TIGR01628
    Location:32275
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:277355
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  5. XM_006511543.2XP_006511606.1  CUGBP Elav-like family member 6 isoform X4

    See identical proteins and their annotated locations for XP_006511606.1

    Conserved Domains (3) summary
    TIGR01628
    Location:32275
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:277355
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  6. XM_017313681.2XP_017169170.1  CUGBP Elav-like family member 6 isoform X6

    Conserved Domains (3) summary
    TIGR01628
    Location:8251
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:253331
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:174
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_011242834.2XP_011241136.1  CUGBP Elav-like family member 6 isoform X4

    See identical proteins and their annotated locations for XP_011241136.1

    Conserved Domains (3) summary
    TIGR01628
    Location:32275
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:277355
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins