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CELF6 CUGBP Elav-like family member 6 [ Homo sapiens (human) ]

Gene ID: 60677, updated on 17-Jun-2019

Summary

Official Symbol
CELF6provided by HGNC
Official Full Name
CUGBP Elav-like family member 6provided by HGNC
Primary source
HGNC:HGNC:14059
See related
Ensembl:ENSG00000140488 MIM:612681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRUNOL6
Summary
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in brain (RPKM 5.2), ovary (RPKM 3.9) and 24 other tissues See more
Orthologs

Genomic context

See CELF6 in Genome Data Viewer
Location:
15q23
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (72284727..72320157, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72577068..72612525, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 6 Neighboring gene uncharacterized LOC105370887 Neighboring gene hexosaminidase subunit alpha Neighboring gene HEXA antisense RNA 1 Neighboring gene ribosomal protein L12 pseudogene 35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Potential readthrough

Included gene: HEXA

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mRNA splice site selection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CUGBP Elav-like family member 6
Names
Bruno -like 6, RNA binding protein
CELF-6
CUG-BP- and ETR-3-like factor 6
RNA-binding protein BRUNOL-6
bruno-like 6, RNA binding protein
bruno-like protein 6
NP_001166155.1
NP_001166156.1
NP_443072.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172684.1NP_001166155.1  CUGBP Elav-like family member 6 isoform 2

    See identical proteins and their annotated locations for NP_001166155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC009690, AF401233, AK296004, DC368992
    Consensus CDS
    CCDS53956.1
    UniProtKB/Swiss-Prot
    Q96J87
    Related
    ENSP00000457863.1, ENST00000567083.2
    Conserved Domains (4) summary
    cd12632
    Location:41127
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:133213
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:365443
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:48454
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  2. NM_001172685.1NP_001166156.1  CUGBP Elav-like family member 6 isoform 3

    See identical proteins and their annotated locations for NP_001166156.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC009690, AK294382, KF456093
    Consensus CDS
    CCDS53955.1
    UniProtKB/Swiss-Prot
    Q96J87
    Related
    ENSP00000439956.2, ENST00000543764.6
    Conserved Domains (3) summary
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:255333
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:2340
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  3. NM_052840.5NP_443072.3  CUGBP Elav-like family member 6 isoform 1

    See identical proteins and their annotated locations for NP_443072.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF401233, AK131098, BM681937, BU732838, CA393931
    Consensus CDS
    CCDS10242.1
    UniProtKB/Swiss-Prot
    Q96J87
    Related
    ENSP00000287202.5, ENST00000287202.10
    Conserved Domains (4) summary
    cd12632
    Location:41127
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:133213
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:392470
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:48477
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    72284727..72320157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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