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Ttpal tocopherol (alpha) transfer protein-like [ Mus musculus (house mouse) ]

Gene ID: 76080, updated on 26-Sep-2022

Summary

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Official Symbol
Ttpalprovided by MGI
Official Full Name
tocopherol (alpha) transfer protein-likeprovided by MGI
Primary source
MGI:MGI:1923330
See related
Ensembl:ENSMUSG00000017679 AllianceGenome:MGI:1923330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3110080A02Rik; 5830472M02Rik
Summary
Predicted to enable phosphatidylinositol bisphosphate binding activity. Orthologous to human TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 8.0), spleen adult (RPKM 7.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ttpal in Genome Data Viewer
Location:
2; 2 H3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163444206..163460933)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163602285..163619013)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hepatic nuclear factor 4 alpha, opposite strand Neighboring gene hepatic nuclear factor 4, alpha Neighboring gene predicted gene, 25881 Neighboring gene Crx opposite strand transcript 1 pseudogene Neighboring gene serine incorporator 3 Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene protein kinase inhibitor, gamma Neighboring gene predicted gene 16316

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
alpha-tocopherol transfer protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305803.1 → NP_001292732.1  alpha-tocopherol transfer protein-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site at an internal exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK033600, BC052389, BC060726, CK640285
    UniProtKB/Swiss-Prot
    Q9D3D0
    UniProtKB/TrEMBL
    A0A6P7QZZ5
    Conserved Domains (2) summary
    smart01100
    Location:57 → 103
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:122 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  2. NM_029512.2 → NP_083788.2  alpha-tocopherol transfer protein-like isoform 1

    See identical proteins and their annotated locations for NP_083788.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK043791, BC052389, BC060726, CJ183358
    Consensus CDS
    CCDS38317.1
    UniProtKB/Swiss-Prot
    Q7TS94, Q9D3D0
    UniProtKB/TrEMBL
    A0A6P5PGP1
    Related
    ENSMUSP00000128922.2, ENSMUST00000171696.8
    Conserved Domains (2) summary
    smart01100
    Location:57 → 103
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:122 → 278
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  3. NM_181734.3 → NP_859423.2  alpha-tocopherol transfer protein-like isoform 1

    See identical proteins and their annotated locations for NP_859423.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK039450, BC052389
    Consensus CDS
    CCDS38317.1
    UniProtKB/Swiss-Prot
    Q7TS94, Q9D3D0
    UniProtKB/TrEMBL
    A0A6P5PGP1
    Related
    ENSMUSP00000105035.4, ENSMUST00000109408.10
    Conserved Domains (2) summary
    smart01100
    Location:57 → 103
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:122 → 278
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

RNA

  1. NR_131225.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate internal splice site and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK039450, BC052389, BC060726, BY717985
    Related
    ENSMUST00000109405.10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163444206..163460933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500362.3 → XP_006500425.1  alpha-tocopherol transfer protein-like isoform X1

    See identical proteins and their annotated locations for XP_006500425.1

    UniProtKB/Swiss-Prot
    Q7TS94, Q9D3D0
    UniProtKB/TrEMBL
    A0A6P5PGP1
    Conserved Domains (2) summary
    smart01100
    Location:57 → 103
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:122 → 278
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  2. XM_006500361.3 → XP_006500424.1  alpha-tocopherol transfer protein-like isoform X1

    See identical proteins and their annotated locations for XP_006500424.1

    UniProtKB/Swiss-Prot
    Q7TS94, Q9D3D0
    UniProtKB/TrEMBL
    A0A6P5PGP1
    Conserved Domains (2) summary
    smart01100
    Location:57 → 103
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:122 → 278
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  3. XM_036162662.1 → XP_036018555.1  alpha-tocopherol transfer protein-like isoform X2

    UniProtKB/TrEMBL
    A0A6P7QZZ5
    Conserved Domains (2) summary
    smart01100
    Location:57 → 103
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:122 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  4. XM_017319317.3 → XP_017174806.1  alpha-tocopherol transfer protein-like isoform X2

    UniProtKB/TrEMBL
    A0A6P7QZZ5
    Conserved Domains (2) summary
    smart01100
    Location:57 → 103
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:122 → 272
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

RNA

  1. XR_003953734.2 RNA Sequence

  2. XR_003953735.2 RNA Sequence

  3. XR_374538.5 RNA Sequence

  4. XR_003953736.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3D0.3 GenPept UniProtKB/Swiss-Prot:Q9D3D0

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