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TTPAL alpha tocopherol transfer protein like [ Homo sapiens (human) ]

Gene ID: 79183, updated on 11-Jun-2021

Summary

Official Symbol
TTPALprovided by HGNC
Official Full Name
alpha tocopherol transfer protein likeprovided by HGNC
Primary source
HGNC:HGNC:16114
See related
Ensembl:ENSG00000124120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf121
Expression
Ubiquitous expression in skin (RPKM 4.7), thyroid (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See TTPAL in Genome Data Viewer
Location:
20q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (44475870..44494603)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43104514..43123244)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1620 Neighboring gene ribosomal protein L37a pseudogene 1 Neighboring gene serine incorporator 3 Neighboring gene Sharpr-MPRA regulatory region 7879 Neighboring gene cAMP-dependent protein kinase inhibitor gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2470, DKFZp686E0870

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane HDA PubMed 

General protein information

Preferred Names
alpha-tocopherol transfer protein-like
Names
tocopherol (alpha) transfer protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039199.3NP_001034288.1  alpha-tocopherol transfer protein-like isoform 1

    See identical proteins and their annotated locations for NP_001034288.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK314045, AL132772, BP351602, Z97053
    Consensus CDS
    CCDS13332.2
    UniProtKB/Swiss-Prot
    Q9BTX7
    UniProtKB/TrEMBL
    B2RA57
    Related
    ENSP00000262605.4, ENST00000262605.9
    Conserved Domains (2) summary
    smart01100
    Location:56102
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:121277
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
  2. NM_001261839.2NP_001248768.1  alpha-tocopherol transfer protein-like isoform 2

    See identical proteins and their annotated locations for NP_001248768.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL132772, BP351602, BQ646722, Z97053
    Related
    ENSP00000412720.1, ENST00000456317.1
    Conserved Domains (2) summary
    smart01100
    Location:56102
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:121243
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
  3. NM_024331.5NP_077307.2  alpha-tocopherol transfer protein-like isoform 1

    See identical proteins and their annotated locations for NP_077307.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AL132772, BC003071, BP351602, Z97053
    Consensus CDS
    CCDS13332.2
    UniProtKB/Swiss-Prot
    Q9BTX7
    Related
    ENSP00000361995.3, ENST00000372904.7
    Conserved Domains (2) summary
    smart01100
    Location:56102
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:121277
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    44475870..44494603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452000.1XP_024307768.1  alpha-tocopherol transfer protein-like isoform X2

    Conserved Domains (2) summary
    smart01100
    Location:56102
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:121243
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
  2. XM_011529045.3XP_011527347.1  alpha-tocopherol transfer protein-like isoform X3

    Conserved Domains (2) summary
    smart01100
    Location:56102
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:121240
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
  3. XM_024452001.1XP_024307769.1  alpha-tocopherol transfer protein-like isoform X4

    Conserved Domains (1) summary
    smart01100
    Location:56102
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
  4. XM_011529043.3XP_011527345.1  alpha-tocopherol transfer protein-like isoform X1

    See identical proteins and their annotated locations for XP_011527345.1

    UniProtKB/Swiss-Prot
    Q9BTX7
    Conserved Domains (2) summary
    smart01100
    Location:56102
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:121277
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
  5. XM_017028063.2XP_016883552.1  alpha-tocopherol transfer protein-like isoform X2

    Conserved Domains (2) summary
    smart01100
    Location:56102
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:121243
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
  6. XM_011529044.3XP_011527346.1  alpha-tocopherol transfer protein-like isoform X1

    See identical proteins and their annotated locations for XP_011527346.1

    UniProtKB/Swiss-Prot
    Q9BTX7
    Conserved Domains (2) summary
    smart01100
    Location:56102
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:121277
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
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