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Srrm2 serine/arginine repetitive matrix 2 [ Mus musculus (house mouse) ]

Gene ID: 75956, updated on 2-Nov-2024

Summary

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Official Symbol
Srrm2provided by MGI
Official Full Name
serine/arginine repetitive matrix 2provided by MGI
Primary source
MGI:MGI:1923206
See related
Ensembl:ENSMUSG00000039218 AllianceGenome:MGI:1923206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SRm300; mKIAA0324; 5033413A03Rik
Summary
Predicted to enable C2H2 zinc finger domain binding activity and mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human SRRM2 (serine/arginine repetitive matrix 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 122.5), ovary adult (RPKM 102.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Srrm2 in Genome Data Viewer
Location:
17 A3.3; 17 12.07 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24009501..24043715)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23790527..23824741)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530082P21 gene Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene STARR-positive B cell enhancer ABC_E4197 Neighboring gene FLYWCH family member 2 Neighboring gene predicted gene, 52285 Neighboring gene STARR-positive B cell enhancer ABC_E11792 Neighboring gene microRNA 5125 Neighboring gene elongin B Neighboring gene serine protease 33 Neighboring gene serine protease 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SRRM2 splicing factor modulates cell fate in early development. Carvalho S, et al. Biol Open, 2024 Apr 15. PMID 38656788, Free PMC Article
  2. A coactivator of pre-mRNA splicing. Blencowe BJ, et al. Genes Dev, 1998 Apr 1. PMID 9531537, Free PMC Article
  3. RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway. Feng Z, et al. Oncogene, 2023 Jun. PMID 37142680
  4. An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs. Ko MS. Nucleic Acids Res, 1990 Oct 11. PMID 2216762, Free PMC Article
  5. SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. Hasegawa K, et al. Dev Cell, 2015 Mar 9. PMID 25703348, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRRM2 splicing factor modulates cell fate in early development.
    Title: SRRM2 splicing factor modulates cell fate in early development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding IEA
Inferred from Electronic Annotation
more info
  
enables C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type catalytic step 2 spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/arginine repetitive matrix protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368687.1 → NP_001355616.1  serine/arginine repetitive matrix protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122821
    Consensus CDS
    CCDS89004.1
    UniProtKB/Swiss-Prot
    E9QNB0, Q3TBY5, Q569P9, Q80U37, Q8BTI8, Q8K383
    Related
    ENSMUSP00000139842.2, ENSMUST00000190686.7
    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam08312
    Location:59 → 101
    cwf21; cwf21 domain

  2. NM_175229.3 → NP_780438.2  serine/arginine repetitive matrix protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122821, AI463539, AK017163, AK090123, AK122248, BQ033752, BY202609, CJ178299
    Consensus CDS
    CCDS37475.1
    UniProtKB/Swiss-Prot
    Q8BTI8
    Related
    ENSMUSP00000085993.5, ENSMUST00000088621.11
    Conserved Domains (1) summary
    pfam02956
    Location:473 → 513
    TT_ORF1; TT viral orf 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24009501..24043715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250131.2 → XP_030105991.1  serine/arginine repetitive matrix protein 2 isoform X6

    Conserved Domains (1) summary
    cl40451
    Location:39 → 102
    cwf21; cwf21 domain

  2. XM_036160825.1 → XP_036016718.1  serine/arginine repetitive matrix protein 2 isoform X6

    Conserved Domains (1) summary
    cl40451
    Location:39 → 102
    cwf21; cwf21 domain

  3. XM_006525077.5 → XP_006525140.1  serine/arginine repetitive matrix protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006525140.1

    UniProtKB/Swiss-Prot
    E9QNB0, Q3TBY5, Q569P9, Q80U37, Q8BTI8, Q8K383
    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam08312
    Location:59 → 101
    cwf21; cwf21 domain

  4. XM_017317709.2 → XP_017173198.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  5. XM_036160822.1 → XP_036016715.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  6. XM_006525079.4 → XP_006525142.1  serine/arginine repetitive matrix protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006525142.1

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  7. XM_017317713.2 → XP_017173202.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  8. XM_017317712.2 → XP_017173201.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  9. XM_030250130.1 → XP_030105990.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  10. XM_017317710.2 → XP_017173199.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  11. XM_017317711.2 → XP_017173200.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  12. XM_017317714.2 → XP_017173203.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  13. XM_036160823.1 → XP_036016716.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  14. XM_030250129.1 → XP_030105989.1  serine/arginine repetitive matrix protein 2 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    cd21375
    Location:39 → 102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

  15. XM_011246701.3 → XP_011245003.1  serine/arginine repetitive matrix protein 2 isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam08312
    Location:59 → 101
    cwf21; cwf21 domain

  16. XM_017317708.2 → XP_017173197.1  serine/arginine repetitive matrix protein 2 isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam08312
    Location:59 → 101
    cwf21; cwf21 domain

  17. XM_011246702.3 → XP_011245004.1  serine/arginine repetitive matrix protein 2 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam08312
    Location:59 → 101
    cwf21; cwf21 domain

  18. XM_006525078.4 → XP_006525141.1  serine/arginine repetitive matrix protein 2 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam08312
    Location:59 → 101
    cwf21; cwf21 domain

  19. XM_011246704.4 → XP_011245006.1  serine/arginine repetitive matrix protein 2 isoform X6

    See identical proteins and their annotated locations for XP_011245006.1

    Conserved Domains (1) summary
    cl40451
    Location:39 → 102
    cwf21; cwf21 domain

  20. XM_036160824.1 → XP_036016717.1  serine/arginine repetitive matrix protein 2 isoform X6

    Conserved Domains (1) summary
    cl40451
    Location:39 → 102
    cwf21; cwf21 domain

  21. XM_030250133.2 → XP_030105993.1  serine/arginine repetitive matrix protein 2 isoform X7

  22. XM_030250132.2 → XP_030105992.1  serine/arginine repetitive matrix protein 2 isoform X6

    Conserved Domains (1) summary
    cl40451
    Location:39 → 102
    cwf21; cwf21 domain

  23. XM_030250128.2 → XP_030105988.1  serine/arginine repetitive matrix protein 2 isoform X1

    UniProtKB/Swiss-Prot
    E9QNB0, Q3TBY5, Q569P9, Q80U37, Q8BTI8, Q8K383
    Conserved Domains (3) summary
    PHA03247
    Location:1982 → 2466
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:309 → 686
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam08312
    Location:59 → 101
    cwf21; cwf21 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTI8.3 GenPept UniProtKB/Swiss-Prot:Q8BTI8

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