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SRRM2 serine/arginine repetitive matrix 2 [ Homo sapiens (human) ]

Gene ID: 23524, updated on 4-Nov-2018

Summary

Official Symbol
SRRM2provided by HGNC
Official Full Name
serine/arginine repetitive matrix 2provided by HGNC
Primary source
HGNC:HGNC:16639
See related
Ensembl:ENSG00000167978 MIM:606032; Vega:OTTHUMG00000177358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CWF21; Cwc21; 300-KD; SRL300; SRm300; HSPC075
Expression
Ubiquitous expression in spleen (RPKM 88.4), bone marrow (RPKM 86.9) and 25 other tissues See more
Orthologs

Genomic context

See SRRM2 in Genome Data Viewer
Location:
16p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (2750903..2771412)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2802330..2821413)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 5 Neighboring gene serine protease 27 Neighboring gene SRRM2 antisense RNA 1 Neighboring gene elongin B Neighboring gene serine protease 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with SRRM2 as demonstrated by proximity dependent biotinylation proteomics PubMed
Tat tat HIV-1 Tat is identified to have a physical interaction with serine/arginine repetitive matrix 2 (SRRM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21926, FLJ22250, KIAA0324, MGC40295, DKFZp667L0421, DKFZp686O15166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C2H2 zinc finger domain binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/arginine repetitive matrix protein 2
Names
300 kDa nuclear matrix antigen
RNA binding protein
SR-related nuclear matrix protein of 300 kDa
ser/Arg-related nuclear matrix protein of 300 kDa
serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa
splicing coactivator subunit SRm300
tax-responsive enhancer element-binding protein 803
taxREB803
testicular secretory protein Li 53

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016333.3NP_057417.3  serine/arginine repetitive matrix protein 2

    See identical proteins and their annotated locations for NP_057417.3

    Status: VALIDATED

    Source sequence(s)
    AB002322, AB016092, AC092117, AI083775
    Consensus CDS
    CCDS32373.1
    UniProtKB/Swiss-Prot
    Q9UQ35
    UniProtKB/TrEMBL
    A0A140VK53
    Related
    ENSP00000301740.8, OTTHUMP00000256420, ENST00000301740.12, OTTHUMT00000436411
    Conserved Domains (4) summary
    pfam08312
    Location:59101
    cwf21; cwf21 domain
    cl26247
    Location:313411
    DNA_pol3_delta2; DNA polymerase III, delta subunit
    cl26386
    Location:21952452
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl28033
    Location:293600
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    2750903..2771412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255226.2XP_005255283.1  serine/arginine repetitive matrix protein 2 isoform X1

    Conserved Domains (1) summary
    pfam08312
    Location:59101
    cwf21; cwf21 domain
  2. XM_006720874.4XP_006720937.1  serine/arginine repetitive matrix protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006720937.1

    Conserved Domains (1) summary
    pfam08312
    Location:59101
    cwf21; cwf21 domain

RNA

  1. XR_932815.2 RNA Sequence

  2. XR_002957795.1 RNA Sequence

  3. XR_001751884.2 RNA Sequence

  4. XR_002957796.1 RNA Sequence

  5. XR_001751885.2 RNA Sequence

  6. XR_932814.2 RNA Sequence

  7. XR_001751880.2 RNA Sequence

  8. XR_243270.2 RNA Sequence

  9. XR_932819.2 RNA Sequence

  10. XR_932817.2 RNA Sequence

  11. XR_002957797.1 RNA Sequence

  12. XR_932822.2 RNA Sequence

  13. XR_001751881.2 RNA Sequence

  14. XR_001751883.2 RNA Sequence

  15. XR_001751882.2 RNA Sequence

  16. XR_932816.2 RNA Sequence

  17. XR_001751886.1 RNA Sequence

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