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SRRM2 serine/arginine repetitive matrix 2 [ Homo sapiens (human) ]

Gene ID: 23524, updated on 23-Nov-2021

Summary

Official Symbol
SRRM2provided by HGNC
Official Full Name
serine/arginine repetitive matrix 2provided by HGNC
Primary source
HGNC:HGNC:16639
See related
Ensembl:ENSG00000167978 MIM:606032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CWF21; Cwc21; 300-KD; SRL300; SRm300; HSPC075
Expression
Ubiquitous expression in spleen (RPKM 88.4), bone marrow (RPKM 86.9) and 25 other tissues See more
Orthologs
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Genomic context

See SRRM2 in Genome Data Viewer
Location:
16p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2750903..2771412)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2802639..2821413)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 5 Neighboring gene serine protease 27 Neighboring gene SRRM2 antisense RNA 1 Neighboring gene elongin B Neighboring gene serine protease 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with SRRM2 as demonstrated by proximity dependent biotinylation proteomics PubMed
Tat tat HIV-1 Tat is identified to have a physical interaction with serine/arginine repetitive matrix 2 (SRRM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21926, FLJ22250, KIAA0324, MGC40295, DKFZp667L0421, DKFZp686O15166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/arginine repetitive matrix protein 2
Names
300 kDa nuclear matrix antigen
RNA binding protein
SR-related nuclear matrix protein of 300 kDa
ser/Arg-related nuclear matrix protein of 300 kDa
serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa
splicing coactivator subunit SRm300
tax-responsive enhancer element-binding protein 803
taxREB803
testicular secretory protein Li 53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016333.4NP_057417.3  serine/arginine repetitive matrix protein 2

    See identical proteins and their annotated locations for NP_057417.3

    Status: VALIDATED

    Source sequence(s)
    AB002322, AB016092, AC092117, AI083775
    Consensus CDS
    CCDS32373.1
    UniProtKB/Swiss-Prot
    Q9UQ35
    UniProtKB/TrEMBL
    A0A140VK53
    Related
    ENSP00000301740.8, ENST00000301740.13
    Conserved Domains (4) summary
    PHA03307
    Location:293600
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK07003
    Location:21952452
    PRK07003; DNA polymerase III subunit gamma/tau
    PRK14971
    Location:313411
    PRK14971; DNA polymerase III subunit gamma/tau
    cd21375
    Location:39102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2750903..2771412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255226.2XP_005255283.1  serine/arginine repetitive matrix protein 2 isoform X1

    Conserved Domains (1) summary
    pfam08312
    Location:59101
    cwf21; cwf21 domain
  2. XM_006720874.4XP_006720937.1  serine/arginine repetitive matrix protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006720937.1

    Conserved Domains (1) summary
    cd21375
    Location:39102
    cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

RNA

  1. XR_932815.2 RNA Sequence

  2. XR_002957795.1 RNA Sequence

  3. XR_001751884.2 RNA Sequence

  4. XR_002957796.1 RNA Sequence

  5. XR_001751885.2 RNA Sequence

  6. XR_932814.2 RNA Sequence

  7. XR_001751880.2 RNA Sequence

  8. XR_243270.2 RNA Sequence

  9. XR_932819.2 RNA Sequence

  10. XR_932817.2 RNA Sequence

  11. XR_002957797.1 RNA Sequence

  12. XR_932822.2 RNA Sequence

  13. XR_001751881.2 RNA Sequence

  14. XR_001751883.2 RNA Sequence

  15. XR_001751882.2 RNA Sequence

  16. XR_932816.2 RNA Sequence

  17. XR_001751886.1 RNA Sequence

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