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Phf14 PHD finger protein 14 [ Mus musculus (house mouse) ]

Gene ID: 75725, updated on 8-Dec-2022

Summary

Official Symbol
Phf14provided by MGI
Official Full Name
PHD finger protein 14provided by MGI
Primary source
MGI:MGI:1923539
See related
Ensembl:ENSMUSG00000029629 AllianceGenome:MGI:1923539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0783; 1110001C23Rik; 4932409F11Rik; 5730446A07Rik
Summary
Predicted to enable histone binding activity. Acts upstream of or within several processes, including lung alveolus development; negative regulation of mesenchymal cell proliferation involved in lung development; and negative regulation of platelet-derived growth factor receptor-alpha signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hindlimb phalanx; and nervous system. Orthologous to human PHF14 (PHD finger protein 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 8.4), CNS E14 (RPKM 6.2) and 19 other tissues See more
Orthologs
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Genomic context

See Phf14 in Genome Data Viewer
Location:
6; 6 A1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (11907728..12100155)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (11907725..12100156)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene EST AA545190 Neighboring gene Ndufa4, mitochondrial complex associated Neighboring gene mitochondrial ribosomal protein L32 pseudogene Neighboring gene predicted gene, 32222 Neighboring gene predicted gene, 35961

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0783

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168382.2NP_001161854.1  PHD finger protein 14 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC153640, AC153641
    Consensus CDS
    CCDS51720.1
    UniProtKB/Swiss-Prot
    Q9D1Q8, Q9D4H9
    Related
    ENSMUSP00000111173.3, ENSMUST00000115511.9
    Conserved Domains (4) summary
    cd15561
    Location:314370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  2. NM_001362122.1NP_001349051.1  PHD finger protein 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153640, AC153641
    Conserved Domains (4) summary
    cd15561
    Location:3692
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:585633
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  3. NM_001362123.1NP_001349052.1  PHD finger protein 14 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153640, AC153641
    UniProtKB/TrEMBL
    A0A8C6GAL9
    Conserved Domains (3) summary
    cd15561
    Location:3692
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  4. NM_029404.4NP_083680.2  PHD finger protein 14 isoform 2

    See identical proteins and their annotated locations for NP_083680.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 3' exons, but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC153640, AC153641
    Consensus CDS
    CCDS39428.1
    UniProtKB/Swiss-Prot
    Q9D4H9
    UniProtKB/TrEMBL
    G5E8S0
    Related
    ENSMUSP00000111172.2, ENSMUST00000115510.8
    Conserved Domains (3) summary
    cd15561
    Location:314370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    11907728..12100155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505202.5XP_006505265.1  PHD finger protein 14 isoform X7

    See identical proteins and their annotated locations for XP_006505265.1

    Conserved Domains (4) summary
    cd15561
    Location:3692
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:585633
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  2. XM_017321819.3XP_017177308.1  PHD finger protein 14 isoform X8

    Conserved Domains (4) summary
    cd15561
    Location:3692
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:585633
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  3. XM_030255656.2XP_030111516.1  PHD finger protein 14 isoform X3

    UniProtKB/Swiss-Prot
    Q9D1Q8
    Conserved Domains (4) summary
    cd15561
    Location:314370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  4. XM_006505197.5XP_006505260.1  PHD finger protein 14 isoform X2

    See identical proteins and their annotated locations for XP_006505260.1

    Conserved Domains (4) summary
    cd15561
    Location:314370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  5. XM_036152388.1XP_036008281.1  PHD finger protein 14 isoform X6

    UniProtKB/TrEMBL
    G5E8S0
    Conserved Domains (3) summary
    cd15561
    Location:314370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  6. XM_011241085.4XP_011239387.1  PHD finger protein 14 isoform X4

    Conserved Domains (4) summary
    cd15561
    Location:314370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  7. XM_006505196.5XP_006505259.1  PHD finger protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006505259.1

    Conserved Domains (4) summary
    cd15561
    Location:314370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  8. XM_006505201.5XP_006505264.1  PHD finger protein 14 isoform X7

    See identical proteins and their annotated locations for XP_006505264.1

    Conserved Domains (4) summary
    cd15561
    Location:3692
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:585633
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  9. XM_006505198.5XP_006505261.1  PHD finger protein 14 isoform X5

    Conserved Domains (3) summary
    cd15561
    Location:314370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

RNA

  1. XR_004933644.1 RNA Sequence

  2. XR_003956264.2 RNA Sequence

  3. XR_004933636.1 RNA Sequence

  4. XR_004933638.1 RNA Sequence

  5. XR_004933640.1 RNA Sequence

  6. XR_004933637.1 RNA Sequence

  7. XR_004933639.1 RNA Sequence

  8. XR_004933641.1 RNA Sequence

  9. XR_004933643.1 RNA Sequence

  10. XR_004933642.1 RNA Sequence

  11. XR_003956263.2 RNA Sequence

  12. XR_003956260.2 RNA Sequence

  13. XR_004933632.1 RNA Sequence

  14. XR_003956261.2 RNA Sequence

  15. XR_004933634.1 RNA Sequence

  16. XR_004933635.1 RNA Sequence

  17. XR_004933633.1 RNA Sequence

  18. XR_004933631.1 RNA Sequence

  19. XR_377293.5 RNA Sequence

  20. XR_004933645.1 RNA Sequence

  21. XR_001785183.3 RNA Sequence