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PHF14 PHD finger protein 14 [ Homo sapiens (human) ]

Gene ID: 9678, updated on 3-May-2025
Official Symbol
PHF14provided by HGNC
Official Full Name
PHD finger protein 14provided by HGNC
Primary source
HGNC:HGNC:22203
See related
Ensembl:ENSG00000106443 MIM:619907; AllianceGenome:HGNC:22203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables histone binding activity. Predicted to be involved in several processes, including germinal center B cell differentiation; lung development; and negative regulation of mesenchymal cell proliferation involved in lung development. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in brain (RPKM 4.6), endometrium (RPKM 2.7) and 25 other tissues See more
Orthologs
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See PHF14 in Genome Data Viewer
Location:
7p21.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (10973872..11169618)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (11104462..11300224)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (11013499..11209245)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:10979917-10980837 Neighboring gene uncharacterized LOC107986767 Neighboring gene NDUFA4 mitochondrial complex associated Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17973 Neighboring gene Sharpr-MPRA regulatory region 7861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17975 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:11022338-11022514 Neighboring gene ribosomal protein L23a pseudogene 52 Neighboring gene MPRA-validated peak6386 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:11224740-11225283 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:11232333-11233080 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:11233081-11233827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25661 Neighboring gene nucleophosmin 1 pseudogene 11 Neighboring gene uncharacterized LOC124901590

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC176640

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone reader activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in germinal center B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in germinal center B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
involved_in lung alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of mesenchymal cell proliferation involved in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal cell proliferation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mesenchymal cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation involved in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mesenchymal cell proliferation involved in lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
PHD finger protein 14

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007157.2NP_001007158.1  PHD finger protein 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA699404, AA837024, AB018326, AK294419, BM834437
    UniProtKB/Swiss-Prot
    A0A0U1RRH6, A7MCZ3, B4DI82, O94880
    Related
    ENSP00000489535.1, ENST00000634607.2
    Conserved Domains (4) summary
    cd15561
    Location:321377
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:727776
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:870918
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:385498
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins
  2. NM_014660.4NP_055475.2  PHD finger protein 14 isoform 2

    See identical proteins and their annotated locations for NP_055475.2

    Status: VALIDATED

    Source sequence(s)
    AC005007, AK294419, BC152414, BM834437, DB359297
    Consensus CDS
    CCDS47542.1
    UniProtKB/Swiss-Prot
    O94880
    UniProtKB/TrEMBL
    B4DG57
    Related
    ENSP00000385795.3, ENST00000403050.7
    Conserved Domains (3) summary
    cd15561
    Location:321377
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:727776
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:385498
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

RNA

  1. NR_033435.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005007, AK294419, DB359297
    Related
    ENST00000642461.1
  2. NR_033436.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294419, AK295461, BG182843
    Related
    ENST00000423760.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    10973872..11169618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    11104462..11300224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)