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Metap1 methionyl aminopeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 75624, updated on 8-Feb-2024

Summary

Official Symbol
Metap1provided by MGI
Official Full Name
methionyl aminopeptidase 1provided by MGI
Primary source
MGI:MGI:1922874
See related
Ensembl:ENSMUSG00000005813 AllianceGenome:MGI:1922874
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0094; 1700029C17Rik
Summary
Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 27.6), CNS E11.5 (RPKM 21.6) and 28 other tissues See more
Orthologs
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Genomic context

See Metap1 in Genome Data Viewer
Location:
3 G3; 3 64.27 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138164721..138195143, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138458960..138489382, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide Neighboring gene STARR-seq mESC enhancer starr_09108 Neighboring gene STARR-positive B cell enhancer ABC_E6139 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide Neighboring gene predicted gene, 32553 Neighboring gene STARR-positive B cell enhancer ABC_E1269 Neighboring gene microRNA 1956 Neighboring gene eukaryotic translation initiation factor 4E Neighboring gene STARR-seq mESC enhancer starr_09110 Neighboring gene predicted gene, 29762

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0094

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables initiator methionyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
methionine aminopeptidase 1
Names
MAP 1
Putative methionine aminopeptidase 1 (MetAP 1) (Peptidase M 1)
metAP 1
peptidase M 1
NP_780433.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175224.4NP_780433.1  methionine aminopeptidase 1

    See identical proteins and their annotated locations for NP_780433.1

    Status: PROVISIONAL

    Source sequence(s)
    AC079845
    Consensus CDS
    CCDS17869.1
    UniProtKB/Swiss-Prot
    Q8BP48
    UniProtKB/TrEMBL
    Q4VAA9
    Related
    ENSMUSP00000029804.9, ENSMUST00000029804.13
    Conserved Domains (1) summary
    cl00279
    Location:14382
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    138164721..138195143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)