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METAP1 methionyl aminopeptidase 1 [ Homo sapiens (human) ]

Gene ID: 23173, updated on 7-Dec-2018

Summary

Official Symbol
METAP1provided by HGNC
Official Full Name
methionyl aminopeptidase 1provided by HGNC
Primary source
HGNC:HGNC:15789
See related
Ensembl:ENSG00000164024 MIM:610151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP1A; MetAP1A
Expression
Ubiquitous expression in esophagus (RPKM 20.9), testis (RPKM 19.8) and 25 other tissues See more
Orthologs

Genomic context

See METAP1 in Genome Data Viewer
Location:
4q23
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (98995637..99063109)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99916788..99983960)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 149 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 4 Neighboring gene microRNA 3684 Neighboring gene activator of basal transcription 1 pseudogene 1 Neighboring gene ADH5 promoter Neighboring gene uncharacterized LOC100507053 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide Neighboring gene ADH4 promoter Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystem (from REACTOME)
    Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystemTo terminate the single photon response and restore the system to its basal state, the three activated intermediates in phototransduction, rhodopsin (MII), transducin alpha subunit with GTP bound (GN...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • The phototransduction cascade, organism-specific biosystem (from REACTOME)
    The phototransduction cascade, organism-specific biosystemThe visual pigment (rhodopsin in rods) consists of an 11-cis-retinal (11cRAL) chromophore covalently attached to a GPCR opsin family member via a Schiff base linkage. Upon photon absorption, 11cRAL i...
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0094, DKFZp781C0419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aminopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metalloexopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
N-terminal protein amino acid modification TAS
Traceable Author Statement
more info
PubMed 
peptidyl-methionine modification TAS
Traceable Author Statement
more info
PubMed 
platelet aggregation HMP PubMed 
protein initiator methionine removal IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of rhodopsin mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
methionine aminopeptidase 1
Names
MAP 1
metAP 1
peptidase M 1
NP_055958.2
XP_011530079.1
XP_011530080.1
XP_011530081.1
XP_016863403.1
XP_016863404.1
XP_016863405.1
XP_016863406.1
XP_024309714.1
XP_024309715.1
XP_024309716.1
XP_024309717.1
XP_024309718.1
XP_024309719.1
XP_024309720.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015143.3NP_055958.2  methionine aminopeptidase 1

    See identical proteins and their annotated locations for NP_055958.2

    Status: VALIDATED

    Source sequence(s)
    BC030054, D42084, DA178462
    Consensus CDS
    CCDS47110.1
    UniProtKB/Swiss-Prot
    P53582
    Related
    ENSP00000296411.6, ENST00000296411.10
    Conserved Domains (3) summary
    PLN03158
    Location:14382
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:136373
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    pfam15801
    Location:1253
    zf-C6H2; zf-MYND-like zinc finger, mRNA-binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    98995637..99063109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007914.2XP_016863403.1  methionine aminopeptidase 1 isoform X4

  2. XM_011531779.2XP_011530081.1  methionine aminopeptidase 1 isoform X3

    Conserved Domains (3) summary
    PLN03158
    Location:14338
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:136329
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    pfam15801
    Location:1253
    zf-C6H2; zf-MYND-like zinc finger, mRNA-binding
  3. XM_017007915.2XP_016863404.1  methionine aminopeptidase 1 isoform X7

  4. XM_024453949.1XP_024309717.1  methionine aminopeptidase 1 isoform X8

    Conserved Domains (1) summary
    cl00279
    Location:3268
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
  5. XM_024453948.1XP_024309716.1  methionine aminopeptidase 1 isoform X8

    Conserved Domains (1) summary
    cl00279
    Location:3268
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
  6. XM_011531777.3XP_011530079.1  methionine aminopeptidase 1 isoform X1

    Conserved Domains (3) summary
    PLN03158
    Location:3369
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:123360
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    cl20224
    Location:2440
    zf-MYND; MYND finger
  7. XM_024453946.1XP_024309714.1  methionine aminopeptidase 1 isoform X5

    Conserved Domains (1) summary
    cl00279
    Location:3325
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
  8. XM_024453952.1XP_024309720.1  methionine aminopeptidase 1 isoform X9

    Conserved Domains (1) summary
    cl00279
    Location:2245
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
  9. XM_024453950.1XP_024309718.1  methionine aminopeptidase 1 isoform X8

    Conserved Domains (1) summary
    cl00279
    Location:3268
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
  10. XM_017007916.2XP_016863405.1  methionine aminopeptidase 1 isoform X7

  11. XM_017007917.2XP_016863406.1  methionine aminopeptidase 1 isoform X7

  12. XM_024453947.1XP_024309715.1  methionine aminopeptidase 1 isoform X6

    Conserved Domains (1) summary
    cl00279
    Location:2303
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
  13. XM_011531778.2XP_011530080.1  methionine aminopeptidase 1 isoform X2

    Conserved Domains (3) summary
    PRK12318
    Location:41337
    PRK12318; methionine aminopeptidase; Provisional
    cd01086
    Location:101338
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    cl20224
    Location:318
    zf-MYND; MYND finger
  14. XM_024453951.1XP_024309719.1  methionine aminopeptidase 1 isoform X8

    Conserved Domains (1) summary
    cl00279
    Location:3268
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
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