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METAP1 methionyl aminopeptidase 1 [ Homo sapiens (human) ]

Gene ID: 23173, updated on 27-Nov-2024

Summary

Official Symbol
METAP1provided by HGNC
Official Full Name
methionyl aminopeptidase 1provided by HGNC
Primary source
HGNC:HGNC:15789
See related
Ensembl:ENSG00000164024 MIM:610151; AllianceGenome:HGNC:15789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP1A; MetAP1A
Summary
Enables aminopeptidase activity. Involved in protein maturation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in esophagus (RPKM 20.9), testis (RPKM 19.8) and 25 other tissues See more
Orthologs
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Genomic context

See METAP1 in Genome Data Viewer
Location:
4q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (98995721..99062809)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (102310655..102377714)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99916872..99983960)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 149 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21736 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15580 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:99917285-99918067 Neighboring gene uncharacterized LOC124900738 Neighboring gene microRNA 3684 Neighboring gene activator of basal transcription 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21737 Neighboring gene ADH5 promoter Neighboring gene uncharacterized LOC100507053 Neighboring gene Sharpr-MPRA regulatory region 12553 Neighboring gene uncharacterized LOC124900739 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0094, DKFZp781C0419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aminopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables initiator methionyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloexopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in cytosolic ribosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
methionine aminopeptidase 1
Names
MAP 1
metAP 1
peptidase M 1
NP_055958.2
XP_011530079.1
XP_011530080.1
XP_011530081.1
XP_016863403.1
XP_016863405.1
XP_016863406.1
XP_024309714.1
XP_024309715.1
XP_024309719.1
XP_047305839.1
XP_047305840.1
XP_047305841.1
XP_047305842.1
XP_047305843.1
XP_054205353.1
XP_054205354.1
XP_054205355.1
XP_054205356.1
XP_054205357.1
XP_054205358.1
XP_054205359.1
XP_054205360.1
XP_054205361.1
XP_054205362.1
XP_054205363.1
XP_054205364.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015143.3NP_055958.2  methionine aminopeptidase 1

    See identical proteins and their annotated locations for NP_055958.2

    Status: VALIDATED

    Source sequence(s)
    BC030054, D42084, DA178462
    Consensus CDS
    CCDS47110.1
    UniProtKB/Swiss-Prot
    B4E2E6, P53582
    UniProtKB/TrEMBL
    Q5CZ91
    Related
    ENSP00000296411.6, ENST00000296411.11
    Conserved Domains (3) summary
    PLN03158
    Location:14382
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:136373
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    pfam15801
    Location:1253
    zf-C6H2; zf-MYND-like zinc finger, mRNA-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    98995721..99062809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007914.3XP_016863403.1  methionine aminopeptidase 1 isoform X4

    UniProtKB/TrEMBL
    Q5CZ91
  2. XM_011531779.3XP_011530081.1  methionine aminopeptidase 1 isoform X3

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (3) summary
    PLN03158
    Location:14338
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:136329
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    pfam15801
    Location:1253
    zf-C6H2; zf-MYND-like zinc finger, mRNA-binding
  3. XM_011531777.4XP_011530079.1  methionine aminopeptidase 1 isoform X1

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (3) summary
    PLN03158
    Location:3369
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:123360
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    cl20224
    Location:2440
    zf-MYND; MYND finger
  4. XM_024453946.2XP_024309714.1  methionine aminopeptidase 1 isoform X6

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (1) summary
    cl00279
    Location:3325
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
  5. XM_047449884.1XP_047305840.1  methionine aminopeptidase 1 isoform X5

  6. XM_047449883.1XP_047305839.1  methionine aminopeptidase 1 isoform X5

  7. XM_017007916.3XP_016863405.1  methionine aminopeptidase 1 isoform X8

    UniProtKB/TrEMBL
    Q5CZ91
  8. XM_017007917.3XP_016863406.1  methionine aminopeptidase 1 isoform X8

    UniProtKB/TrEMBL
    Q5CZ91
  9. XM_047449885.1XP_047305841.1  methionine aminopeptidase 1 isoform X5

  10. XM_011531778.3XP_011530080.1  methionine aminopeptidase 1 isoform X2

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (3) summary
    PRK12318
    Location:41337
    PRK12318; methionine aminopeptidase; Provisional
    cd01086
    Location:101338
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    cl20224
    Location:318
    zf-MYND; MYND finger
  11. XM_024453947.2XP_024309715.1  methionine aminopeptidase 1 isoform X7

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (1) summary
    cl00279
    Location:2303
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
  12. XM_047449886.1XP_047305842.1  methionine aminopeptidase 1 isoform X9

  13. XM_047449887.1XP_047305843.1  methionine aminopeptidase 1 isoform X9

  14. XM_024453951.2XP_024309719.1  methionine aminopeptidase 1 isoform X9

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (1) summary
    cl00279
    Location:3268
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    102310655..102377714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349381.1XP_054205356.1  methionine aminopeptidase 1 isoform X4

  2. XM_054349380.1XP_054205355.1  methionine aminopeptidase 1 isoform X3

  3. XM_054349378.1XP_054205353.1  methionine aminopeptidase 1 isoform X1

  4. XM_054349383.1XP_054205358.1  methionine aminopeptidase 1 isoform X6

  5. XM_054349385.1XP_054205360.1  methionine aminopeptidase 1 isoform X8

  6. XM_054349386.1XP_054205361.1  methionine aminopeptidase 1 isoform X8

  7. XM_054349384.1XP_054205359.1  methionine aminopeptidase 1 isoform X7

  8. XM_054349379.1XP_054205354.1  methionine aminopeptidase 1 isoform X2

  9. XM_054349382.1XP_054205357.1  methionine aminopeptidase 1 isoform X5

  10. XM_054349387.1XP_054205362.1  methionine aminopeptidase 1 isoform X9

  11. XM_054349388.1XP_054205363.1  methionine aminopeptidase 1 isoform X9

  12. XM_054349389.1XP_054205364.1  methionine aminopeptidase 1 isoform X9