U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ep400 E1A binding protein p400 [ Mus musculus (house mouse) ]

Gene ID: 75560, updated on 18-Apr-2024

Summary

Official Symbol
Ep400provided by MGI
Official Full Name
E1A binding protein p400provided by MGI
Primary source
MGI:MGI:1276124
See related
Ensembl:ENSMUSG00000029505 AllianceGenome:MGI:1276124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p400; mDomino; mKIAA1498; 1700020J09Rik
Summary
Predicted to enable chromatin binding activity and protein antigen binding activity. Predicted to be involved in histone H2A acetylation and histone H4 acetylation. Predicted to act upstream of or within chromatin organization. Located in nuclear speck. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; gut; and trachea. Orthologous to human EP400 (E1A binding protein p400). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 36.8), thymus adult (RPKM 23.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
5 F; 5 53.69 cM
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110812239..110918583, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110664373..110770927, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene NOC4 like Neighboring gene DEAD box helicase 51 Neighboring gene microRNA 7026 Neighboring gene STARR-positive B cell enhancer ABC_E3599 Neighboring gene predicted gene, 22716 Neighboring gene predicted gene, 26079 Neighboring gene predicted gene, 22583 Neighboring gene STARR-positive B cell enhancer ABC_E2169 Neighboring gene predicted gene 15559 Neighboring gene pseudouridine synthase 1 Neighboring gene unc-51 like kinase 1 Neighboring gene STARR-seq mESC enhancer starr_13967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:111239028-111239211

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E1A-binding protein p400
Names
domino homolog
p400 kDa SWI2/SNF2-related protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029337.2NP_083613.2  E1A-binding protein p400 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
    Source sequence(s)
    AC161348
    Consensus CDS
    CCDS19529.1
    UniProtKB/Swiss-Prot
    E9QKV1, Q3TPY1, Q5RKN8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8CHI8, Q8VDF4, Q9DA54
    Related
    ENSMUSP00000049038.9, ENSMUST00000041558.15
    Conserved Domains (7) summary
    PHA03255
    Location:25112639
    PHA03255; BDLF3; Provisional
    smart00573
    Location:762833
    HSA; domain in helicases and associated with SANT domains
    cd00046
    Location:10731208
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:10561336
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:17761892
    Helicase_C; Helicase conserved C-terminal domain
    pfam03153
    Location:28223011
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam15790
    Location:1451
    EP400_N; E1A-binding protein p400, N-terminal
  2. NM_173066.1NP_775089.1  E1A-binding protein p400 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), also called mDomino-S, lacks an in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC161348
    Consensus CDS
    CCDS51612.1
    UniProtKB/Swiss-Prot
    E9QKV1, Q3TPY1, Q5RKN8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8CHI8, Q8VDF4, Q9DA54
    Related
    ENSMUSP00000108055.3, ENSMUST00000112436.9
    Conserved Domains (7) summary
    PHA03255
    Location:24752603
    PHA03255; BDLF3; Provisional
    smart00573
    Location:726797
    HSA; domain in helicases and associated with SANT domains
    cd00046
    Location:10371172
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:10201300
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:17401856
    Helicase_C; Helicase conserved C-terminal domain
    pfam03153
    Location:27862975
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam15790
    Location:1451
    EP400_N; E1A-binding protein p400, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110812239..110918583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)