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EP400 E1A binding protein p400 [ Homo sapiens (human) ]

Gene ID: 57634, updated on 4-Nov-2018


Official Symbol
EP400provided by HGNC
Official Full Name
E1A binding protein p400provided by HGNC
Primary source
See related
Ensembl:ENSG00000183495 MIM:606265; Vega:OTTHUMG00000187346
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P400; CAGH32; TNRC12
Ubiquitous expression in testis (RPKM 8.1), ovary (RPKM 5.8) and 25 other tissues See more

Genomic context

See EP400 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (131949920..132080466)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (132434465..132565011)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984455 Neighboring gene pseudouridine synthase 1 Neighboring gene small nucleolar RNA, H/ACA box 49 Neighboring gene EP400 pseudogene 1 Neighboring gene uncharacterized LOC107987169 Neighboring gene DEAD-box helicase 51

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016


GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The core of the p400/TRRAP complex, consists of BAF53A, P400, RUVBL1, RUVBL2, TRRAP, are identified to interact with HIV-1 Tat in Jurkat cell PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • DNA Damage/Telomere Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    DNA Damage/Telomere Stress Induced Senescence, organism-specific biosystemReactive oxygen species (ROS), whose concentration increases in senescent cells due to oncogenic RAS-induced mitochondrial dysfunction (Moiseeva et al. 2009) or due to environmental stress, cause DNA...
  • Formation of Senescence-Associated Heterochromatin Foci (SAHF), organism-specific biosystem (from REACTOME)
    Formation of Senescence-Associated Heterochromatin Foci (SAHF), organism-specific biosystemThe process of DNA damage/telomere stress induced senescence culminates in the formation of senescence associated heterochromatin foci (SAHF). These foci represent facultative heterochromatin that is...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ42018, FLJ45115, DKFZP434I225

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
DNA binding IEA
Inferred from Electronic Annotation
more info
chromatin binding IEA
Inferred from Electronic Annotation
more info
helicase activity IEA
Inferred from Electronic Annotation
more info
protein antigen binding IEA
Inferred from Electronic Annotation
more info
protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
histone H2A acetylation IDA
Inferred from Direct Assay
more info
histone H4 acetylation IDA
Inferred from Direct Assay
more info
Component Evidence Code Pubs
NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
Swr1 complex IDA
Inferred from Direct Assay
more info
nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
nucleoplasm TAS
Traceable Author Statement
more info

General protein information

Preferred Names
E1A-binding protein p400
CAG repeat protein 32
domino homolog
p400 SWI2/SNF2-related protein
p400 kDa SWI2/SNF2-related protein
trinucleotide repeat containing 12
trinucleotide repeat-containing gene 12 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015409.4NP_056224.3  E1A-binding protein p400

    Status: VALIDATED

    Source sequence(s)
    AB058721, AC137590, AC137632, AY044869, DA450209
    Consensus CDS
    ENSP00000374212.2, ENST00000389561.6
    Conserved Domains (5) summary
    HSA; domain in helicases and associated with SANT domains
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    SNF2_N; SNF2 family N-terminal domain
    Helicase_C; Helicase conserved C-terminal domain
    EP400_N; E1A-binding protein p400, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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