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Sirt4 sirtuin 4 [ Mus musculus (house mouse) ]

Gene ID: 75387, updated on 18-Sep-2024

Summary

Official Symbol
Sirt4provided by MGI
Official Full Name
sirtuin 4provided by MGI
Primary source
MGI:MGI:1922637
See related
Ensembl:ENSMUSG00000029524 AllianceGenome:MGI:1922637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930596O17Rik
Summary
Enables NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; and lipoamidase activity. Involved in several processes, including carboxylic acid metabolic process; cellular protein modification process; and regulation of cellular ketone metabolic process. Acts upstream of or within negative regulation of insulin secretion. Located in mitochondrial inner membrane and mitochondrial matrix. Is expressed in several structures, including gonad; heart; nervous system; respiratory system; and thyroid gland. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 8.3), bladder adult (RPKM 7.5) and 28 other tissues See more
Orthologs
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Genomic context

See Sirt4 in Genome Data Viewer
Location:
5 F; 5 56.1 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115616065..115628322, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115478006..115490264, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene musashi RNA-binding protein 1 Neighboring gene phospholipase A2, group IB, pancreas Neighboring gene STARR-seq mESC enhancer starr_14129 Neighboring gene predicted gene, 42007 Neighboring gene predicted gene, 24265 Neighboring gene STARR-seq mESC enhancer starr_14130 Neighboring gene predicted gene, 24407 Neighboring gene 40S ribosomal protein S5 pseudogene Neighboring gene paxillin Neighboring gene predicted gene 13840 Neighboring gene STARR-seq mESC enhancer starr_14131

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD+-protein poly-ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables NAD+-protein poly-ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NAD+-protein-cysteine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent protein biotinidase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent protein biotinidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NAD-dependent protein lipoamidase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent protein lipoamidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NAD-dependent protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lipoamidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glutamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fatty acid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein processing involved in protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein processing involved in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of glutamine family amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of pyruvate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of pyruvate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Names
NAD-dependent protein biotinylase sirtuin-4
NP_001161163.1
NP_598521.1
XP_006530543.1
XP_006530544.1
XP_017176616.1
XP_030110726.1
XP_030110728.1
XP_036021467.1
XP_036021468.1
XP_036021469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167691.1NP_001161163.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

    See identical proteins and their annotated locations for NP_001161163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117735, AC159539
    Consensus CDS
    CCDS51628.1
    UniProtKB/Swiss-Prot
    D3Z1D9, Q8R216
    Related
    ENSMUSP00000107698.2, ENSMUST00000112067.8
    Conserved Domains (1) summary
    cd01409
    Location:44305
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
  2. NM_133760.1NP_598521.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

    See identical proteins and their annotated locations for NP_598521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117735, AC159539
    Consensus CDS
    CCDS51628.1
    UniProtKB/Swiss-Prot
    D3Z1D9, Q8R216
    Related
    ENSMUSP00000107697.2, ENSMUST00000112066.2
    Conserved Domains (1) summary
    cd01409
    Location:44305
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115616065..115628322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254868.2XP_030110728.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

    UniProtKB/Swiss-Prot
    D3Z1D9, Q8R216
    Conserved Domains (1) summary
    cd01409
    Location:44305
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
  2. XM_017321127.3XP_017176616.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

    UniProtKB/Swiss-Prot
    D3Z1D9, Q8R216
    Conserved Domains (1) summary
    cd01409
    Location:44305
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
  3. XM_036165575.1XP_036021468.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd01409
    Location:85356
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
  4. XM_030254866.2XP_030110726.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

    Conserved Domains (1) summary
    cd01409
    Location:44315
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
  5. XM_006530480.4XP_006530543.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_006530543.1

    Conserved Domains (1) summary
    cd01409
    Location:44315
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
  6. XM_036165574.1XP_036021467.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd01409
    Location:85356
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
  7. XM_036165576.1XP_036021469.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd01409
    Location:44305
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
  8. XM_006530481.4XP_006530544.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_006530544.1

    Conserved Domains (1) summary
    cd01409
    Location:44315
    SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...

RNA

  1. XR_004942581.1 RNA Sequence

  2. XR_004942583.1 RNA Sequence

  3. XR_004942582.1 RNA Sequence

  4. XR_004942579.1 RNA Sequence

  5. XR_004942580.1 RNA Sequence