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Sirt4 sirtuin 4 [ Mus musculus (house mouse) ]

Gene ID: 75387, updated on 5-Aug-2018

Summary

Official Symbol
Sirt4provided by MGI
Official Full Name
sirtuin 4provided by MGI
Primary source
MGI:MGI:1922637
See related
Ensembl:ENSMUSG00000029524 Vega:OTTMUSG00000014665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930596O17Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 8.3), bladder adult (RPKM 7.5) and 28 other tissues See more
Orthologs

Genomic context

See Sirt4 in Genome Data Viewer
Location:
5; 5 F
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (115478006..115490155, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (115928019..115934493, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene musashi RNA-binding protein 1 Neighboring gene RIKEN cDNA A930005G22 gene Neighboring gene phospholipase A2, group IB, pancreas Neighboring gene uncharacterized LOC102639758 Neighboring gene predicted gene, 42007 Neighboring gene predicted gene 13840 Neighboring gene paxillin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
biotinidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lipoamidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoamidase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
glutamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fatty acid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein processing involved in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
protein ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glutamine family amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of pyruvate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of pyruvate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
tricarboxylic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
NP_001161163.1
NP_598521.1
XP_006530542.1
XP_006530543.1
XP_006530544.1
XP_006530545.1
XP_006530546.1
XP_006530547.1
XP_006530548.1
XP_017176616.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167691.1NP_001161163.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

    See identical proteins and their annotated locations for NP_001161163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117735, AC159539
    Consensus CDS
    CCDS51628.1
    UniProtKB/Swiss-Prot
    Q8R216
    Related
    ENSMUSP00000107698.1, OTTMUSP00000015567, ENSMUST00000112067.7, OTTMUST00000034795
    Conserved Domains (1) summary
    cd01409
    Location:44305
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  2. NM_133760.1NP_598521.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

    See identical proteins and their annotated locations for NP_598521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117735, AC159539
    Consensus CDS
    CCDS51628.1
    UniProtKB/Swiss-Prot
    Q8R216
    Related
    ENSMUSP00000107697.1, OTTMUSP00000015568, ENSMUST00000112066.1, OTTMUST00000034796
    Conserved Domains (1) summary
    cd01409
    Location:44305
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    115478006..115490155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321127.1XP_017176616.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    Q8R216
    Conserved Domains (1) summary
    cd01409
    Location:44305
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  2. XM_006530482.3XP_006530545.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd01409
    Location:44315
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  3. XM_006530480.2XP_006530543.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006530543.1

    Conserved Domains (1) summary
    cd01409
    Location:44315
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  4. XM_006530479.3XP_006530542.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006530542.1

    Conserved Domains (1) summary
    cd01409
    Location:44315
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  5. XM_006530481.2XP_006530544.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006530544.1

    Conserved Domains (1) summary
    cd01409
    Location:44315
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  6. XM_006530483.3XP_006530546.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd01409
    Location:44305
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  7. XM_006530485.3XP_006530548.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X6

    Conserved Domains (1) summary
    cl00195
    Location:44262
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  8. XM_006530484.3XP_006530547.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl00195
    Location:44262
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
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