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SIRT4 sirtuin 4 [ Homo sapiens (human) ]

Gene ID: 23409, updated on 8-Oct-2017
Official Symbol
SIRT4provided by HGNC
Official Full Name
sirtuin 4provided by HGNC
Primary source
HGNC:HGNC:14932
See related
Ensembl:ENSG00000089163 MIM:604482; Vega:OTTHUMG00000169028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L4
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Orthologs
Location:
12q24.23-q24.31
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (120292199..120313242)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120730002..120751045)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 pseudogene 1 Neighboring gene RNA, U4 small nuclear 2 Neighboring gene RNA, U4 small nuclear 1 Neighboring gene RNA, U6 small nuclear 1088, pseudogene Neighboring gene phospholipase A2 group IB Neighboring gene musashi RNA binding protein 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • NAD+ biosynthetic pathways, organism-specific biosystem (from WikiPathways)
    NAD+ biosynthetic pathways, organism-specific biosystemNAD+ biosynthetic pathways. NAD+ levels are maintained by three independent pathways. First, the Preiss-Handler pathway uses dietary nicotinic acid and the enzyme nicotinic acid phosphoribosyltransfe...
  • NAD+ metabolism, organism-specific biosystem (from WikiPathways)
    NAD+ metabolism, organism-specific biosystemNAD+ metabolism in different cellular compartments. The different precursors to intracellular NAD metabolism - tryptophan, nicotinic acid (NA), nicotinamide, NR, and NMN - are shown, along with their...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC57437, MGC130046, MGC130047

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NOT NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
biotinidase activity IDA
Inferred from Direct Assay
more info
PubMed 
lipoamidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
chromatin silencing TAS
Traceable Author Statement
more info
PubMed 
glutamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion organization TAS
Traceable Author Statement
more info
 
negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein processing involved in protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ADP-ribosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
regulation of glutamine family amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of pyruvate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
tricarboxylic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Names
NAD-dependent ADP-ribosyltransferase sirtuin-4
NAD-dependent protein deacetylase sirtuin-4
SIR2-like protein 4
regulatory protein SIR2 homolog 4
sir2-like 4
sirtuin type 4
NP_036372.1
XP_005253922.1
XP_006719371.1
XP_006719372.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012240.2NP_036372.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

    See identical proteins and their annotated locations for NP_036372.1

    Status: REVIEWED

    Source sequence(s)
    AF083109, BP232525
    Consensus CDS
    CCDS9194.1
    UniProtKB/Swiss-Prot
    Q9Y6E7
    Related
    ENSP00000202967.4, OTTHUMP00000239957, ENST00000202967.4, OTTHUMT00000402003
    Conserved Domains (1) summary
    cd01409
    Location:47308
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

    Range
    120292199..120313242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719308.2XP_006719371.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006719371.1

    UniProtKB/Swiss-Prot
    Q9Y6E7
    Conserved Domains (1) summary
    cd01409
    Location:47308
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  2. XM_006719309.3XP_006719372.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006719372.1

    UniProtKB/Swiss-Prot
    Q9Y6E7
    Conserved Domains (1) summary
    cd01409
    Location:47308
    SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  3. XM_005253865.4XP_005253922.1  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00195
    Location:47217
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    120708119..120718976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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