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ZFP36 ZFP36 ring finger protein [ Homo sapiens (human) ]

Gene ID: 7538, updated on 5-Aug-2022

Summary

Official Symbol
ZFP36provided by HGNC
Official Full Name
ZFP36 ring finger proteinprovided by HGNC
Primary source
HGNC:HGNC:12862
See related
Ensembl:ENSG00000128016 MIM:190700; AllianceGenome:HGNC:12862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTP; G0S24; GOS24; TIS11; NUP475; zfp-36; RNF162A
Summary
Enables several functions, including 14-3-3 protein binding activity; heat shock protein binding activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to growth factor stimulus; and regulation of gene expression. Acts upstream of or within mRNA catabolic process. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Part of ribonucleoprotein complex. Colocalizes with RISC-loading complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in gall bladder (RPKM 274.6), bone marrow (RPKM 248.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZFP36 in Genome Data Viewer
Location:
19q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39406847..39409407)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42211127..42213687)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39897487..39900047)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4B Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene mediator complex subunit 29 Neighboring gene pleckstrin homology and RhoGEF domain containing G2 Neighboring gene tRNA-Ile (anticodon TAT) 1-1 Neighboring gene microRNA 4530

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of tristetraprolin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables C-C chemokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables RNA polymerase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heat shock protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding TAS
Traceable Author Statement
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in 3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-2 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of polynucleotide adenylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of viral transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of miRNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of keratinocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mRNA decay activator protein ZFP36
Names
G0/G1 switch regulatory protein 24
growth factor-inducible nuclear protein NUP475
tristetraprolin
tristetraproline
zinc finger protein 36 homolog
zinc finger protein 36, C3H type, homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003407.5NP_003398.3  mRNA decay activator protein ZFP36

    Status: VALIDATED

    Source sequence(s)
    AC011500, M92843
    Consensus CDS
    CCDS12534.2
    UniProtKB/Swiss-Prot
    B2RA54
    Related
    ENSP00000469647.2, ENST00000597629.3
    Conserved Domains (1) summary
    cl11592
    Location:104200
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39406847..39409407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42211127..42213687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)