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ZFP36 ZFP36 ring finger protein [ Homo sapiens (human) ]

Gene ID: 7538, updated on 2-Jul-2019

Summary

Official Symbol
ZFP36provided by HGNC
Official Full Name
ZFP36 ring finger proteinprovided by HGNC
Primary source
HGNC:HGNC:12862
See related
Ensembl:ENSG00000128016 MIM:190700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTP; G0S24; GOS24; TIS11; NUP475; zfp-36; RNF162A
Expression
Ubiquitous expression in gall bladder (RPKM 274.6), bone marrow (RPKM 248.5) and 25 other tissues See more
Orthologs

Genomic context

See ZFP36 in Genome Data Viewer
Location:
19q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39406847..39409407)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39897487..39900052)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4B Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene mediator complex subunit 29 Neighboring gene tRNA-Ile (anticodon TAT) 1-1 Neighboring gene microRNA 4530

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of tristetraprolin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
    ErbB1 downstream signaling, organism-specific biosystem
    ErbB1 downstream signaling
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
    Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...
  • Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystem (from REACTOME)
    Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, organism-specific biosystem (from REACTOME)
    Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, organism-specific biosystemTristetraproline (TTP) binds RNAs that contain AU-rich elements and recruits enzymes that degrade RNA. TTP interacts with the exosome (3' to 5' exonuclease), XRN1 (5' to 3' exonuclease), and the deca...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
C-C chemokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA polymerase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
heat shock protein binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR AU-rich region binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA 3'-UTR AU-rich region binding TAS
Traceable Author Statement
more info
PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
mRNA transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
miRNA mediated inhibition of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-2 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of polynucleotide adenylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of viral transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
regulation of keratinocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with CCR4-NOT complex ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with Dcp1-Dcp2 complex IDA
Inferred from Direct Assay
more info
PubMed 
P-body IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with RISC-loading complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
NOT colocalizes_with exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mRNA decay activator protein ZFP36
Names
G0/G1 switch regulatory protein 24
growth factor-inducible nuclear protein NUP475
tristetraprolin
tristetraproline
zinc finger protein 36 homolog
zinc finger protein 36, C3H type, homolog
zinc finger protein, C3H type, 36 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003407.5NP_003398.3  mRNA decay activator protein ZFP36

    Status: VALIDATED

    Source sequence(s)
    AC011500, M92843
    Consensus CDS
    CCDS12534.2
    Related
    ENSP00000471239.2, ENST00000594442.2
    Conserved Domains (1) summary
    cl11592
    Location:104200
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    39406847..39409407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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