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YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [ Homo sapiens (human) ]

Gene ID: 7533, updated on 4-Oct-2020

Summary

Official Symbol
YWHAHprovided by HGNC
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaprovided by HGNC
Primary source
HGNC:HGNC:12853
See related
Ensembl:ENSG00000128245 MIM:113508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YWHA1
Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Expression
Broad expression in brain (RPKM 343.5), lung (RPKM 62.6) and 22 other tissues See more
Orthologs

Genomic context

See YWHAH in Genome Data Viewer
Location:
22q12.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (31944535..31957603)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (32340479..32353590)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene DEP domain containing 5, GATOR1 subcomplex subunit Neighboring gene transcription and mRNA export factor ENY2 pseudogene Neighboring gene uncharacterized LOC105372998 Neighboring gene chromosome 22 putative open reading frame 24 Neighboring gene long intergenic non-protein coding RNA 2558 Neighboring gene origin of replication NOA3 Neighboring gene RNA, 7SL, cytoplasmic 305, pseudogene Neighboring gene ribosomal protein S17 pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
vpr HIV-1 Vpr forms a triple complex with 14-3-3 eta and Cdc25C and thereby promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C PubMed
vpr Yeast two-hybrid assays show that HIV-1 Vpr binds strongly to 14-3-3 eta amino acids 141 to 244; the smallest 14-3-3 eta fragment (residues 190-210) also supports this binding, and amino acid mutation R80A in Vpr abolishes the binding to 14-3-3 eta PubMed
vpr Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
glucocorticoid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
sodium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intercalated disc IC
Inferred by Curator
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
14-3-3 protein eta
Names
14-3-3 eta
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003405.4NP_003396.1  14-3-3 protein eta

    See identical proteins and their annotated locations for NP_003396.1

    Status: REVIEWED

    Source sequence(s)
    AY007132, BC003047, Z82248
    Consensus CDS
    CCDS13901.1
    UniProtKB/Swiss-Prot
    Q04917
    UniProtKB/TrEMBL
    A0A024R1K7, Q9H4N8
    Related
    ENSP00000248975.5, ENST00000248975.6
    Conserved Domains (1) summary
    cd10025
    Location:3241
    14-3-3_eta; 14-3-3 eta, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    31944535..31957603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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