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Meiob meiosis specific with OB domains [ Mus musculus (house mouse) ]

Gene ID: 75178, updated on 5-Jan-2023

Summary

Official Symbol
Meiobprovided by MGI
Official Full Name
meiosis specific with OB domainsprovided by MGI
Primary source
MGI:MGI:1922428
See related
Ensembl:ENSMUSG00000024155 AllianceGenome:MGI:1922428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MLZ-675; 4930528F23Rik
Summary
Enables chromatin binding activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; and single-stranded DNA binding activity. Involved in double-strand break repair via homologous recombination; fertilization; and meiosis I. Acts upstream of or within male meiotic nuclear division. Located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in spermatogenic failure 22. Orthologous to human MEIOB (meiosis specific with OB-fold). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.7), liver E14 (RPKM 0.5) and 4 other tissues See more
Orthologs
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Genomic context

See Meiob in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25023275..25058762)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24804301..24839788)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene methionine sulfoxide reductase B1 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 6 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene predicted gene, 41549 Neighboring gene insulin-like growth factor binding protein, acid labile subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA 3'-5' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA 3'-5' DNA exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
meiosis-specific with OB domain-containing protein
Names
protein expressed in male leptotene and zygotene spermatocytes 675

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029197.1NP_083473.1  meiosis-specific with OB domain-containing protein

    See identical proteins and their annotated locations for NP_083473.1

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS50020.1
    UniProtKB/Swiss-Prot
    E9QLG1, Q9D513
    Related
    ENSMUSP00000024972.6, ENSMUST00000024972.7
    Conserved Domains (2) summary
    cd04475
    Location:167269
    RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
    TIGR00617
    Location:165408
    rpa1; replication factor-a protein 1 (rpa1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25023275..25058762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525045.4XP_006525108.1  meiosis-specific with OB domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_006525108.1

    UniProtKB/Swiss-Prot
    E9QLG1, Q9D513
    Conserved Domains (2) summary
    cd04475
    Location:167269
    RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
    TIGR00617
    Location:165408
    rpa1; replication factor-a protein 1 (rpa1)
  2. XM_017317702.2XP_017173191.1  meiosis-specific with OB domain-containing protein isoform X2

    Conserved Domains (2) summary
    cd04475
    Location:167269
    RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
    TIGR00617
    Location:165405
    rpa1; replication factor-a protein 1 (rpa1)
  3. XM_006525047.4XP_006525110.1  meiosis-specific with OB domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_006525110.1

    UniProtKB/Swiss-Prot
    E9QLG1, Q9D513
    Conserved Domains (2) summary
    cd04475
    Location:167269
    RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
    TIGR00617
    Location:165408
    rpa1; replication factor-a protein 1 (rpa1)
  4. XM_006525048.5XP_006525111.1  meiosis-specific with OB domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_006525111.1

    UniProtKB/Swiss-Prot
    E9QLG1, Q9D513
    Conserved Domains (2) summary
    cd04475
    Location:167269
    RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
    TIGR00617
    Location:165408
    rpa1; replication factor-a protein 1 (rpa1)
  5. XM_006525052.4XP_006525115.1  meiosis-specific with OB domain-containing protein isoform X3

    Conserved Domains (2) summary
    cd04475
    Location:45147
    RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
    TIGR00617
    Location:43286
    rpa1; replication factor-a protein 1 (rpa1)