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MEIOB meiosis specific with OB-fold [ Homo sapiens (human) ]

Gene ID: 254528, updated on 22-Aug-2021

Summary

Official Symbol
MEIOBprovided by HGNC
Official Full Name
meiosis specific with OB-foldprovided by HGNC
Primary source
HGNC:HGNC:28569
See related
Ensembl:ENSG00000162039 MIM:617670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
gs129; SPGF22; C16orf73
Expression
Restricted expression toward testis (RPKM 20.3) See more
Orthologs
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Genomic context

See MEIOB in Genome Data Viewer
Location:
16p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1833986..1872164, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1883987..1922165, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene insulin like growth factor binding protein acid labile subunit Neighboring gene hydroxyacylglutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene long intergenic non-protein coding RNA 254 Neighboring gene long intergenic non-protein coding RNA 2124

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC35212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables single-stranded DNA 3'-5' exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA 3'-5' exodeoxyribonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in female meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in male meiosis I IEA
Inferred from Electronic Annotation
more info
 
involved_in male meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in resolution of meiotic recombination intermediates ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
meiosis-specific with OB domain-containing protein
Names
meiosis specific with OB domains

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163560.3NP_001157032.1  meiosis-specific with OB domain-containing protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL031722, AL499628
    Consensus CDS
    CCDS53983.1
    UniProtKB/Swiss-Prot
    Q8N635
    Related
    ENSP00000314484.3, ENST00000325962.9
    Conserved Domains (2) summary
    cd04475
    Location:167270
    RPA1_DBD_B; RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    cl09930
    Location:345421
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
  2. NM_152764.3NP_689977.2  meiosis-specific with OB domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_689977.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AL031722, AL499628, BC029829, CD300613, DB461414
    Consensus CDS
    CCDS10449.2
    UniProtKB/Swiss-Prot
    Q8N635
    Related
    ENSP00000380504.3, ENST00000397344.7
    Conserved Domains (1) summary
    cd04475
    Location:167270
    RPA1_DBD_B; RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1833986..1872164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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