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CSKMT citrate synthase lysine methyltransferase [ Homo sapiens (human) ]

Gene ID: 751071, updated on 5-Aug-2022

Summary

Official Symbol
CSKMTprovided by HGNC
Official Full Name
citrate synthase lysine methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:33113
See related
Ensembl:ENSG00000214756 MIM:617897; AllianceGenome:HGNC:33113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
U99HG; CS-KMT; METTL12
Summary
Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine dimethylation; peptidyl-lysine monomethylation; and peptidyl-lysine trimethylation. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 1.7), endometrium (RPKM 1.6) and 25 other tissues See more
Orthologs
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Genomic context

See CSKMT in Genome Data Viewer
Location:
11q12.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62665312..62668108)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62654730..62657526)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62432784..62435580)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 5 Neighboring gene chromosome 11 open reading frame 98 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3 Neighboring gene UBX domain protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial
Names
methyltransferase like 12
methyltransferase-like protein 12, mitochondrial
NP_001036694.1
XP_005274289.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043229.2NP_001036694.1  citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001036694.1

    Status: VALIDATED

    Source sequence(s)
    AP001458, BG676615, BX348415, BY796224
    Consensus CDS
    CCDS41657.1
    UniProtKB/Swiss-Prot
    A8MUP2, B7Z4C1
    Related
    ENSP00000431287.1, ENST00000532971.2
    Conserved Domains (1) summary
    pfam13847
    Location:75196
    Methyltransf_31; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62665312..62668108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274232.6XP_005274289.1  citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam13847
    Location:198319
    Methyltransf_31; Methyltransferase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62654730..62657526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)