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Mei4 meiotic double-stranded break formation protein 4 [ Mus musculus (house mouse) ]

Gene ID: 75033, updated on 8-Feb-2024

Summary

Official Symbol
Mei4provided by MGI
Official Full Name
meiotic double-stranded break formation protein 4provided by MGI
Primary source
MGI:MGI:1922283
See related
Ensembl:ENSMUSG00000043289 AllianceGenome:MGI:1922283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930486G11Rik
Summary
Involved in meiotic DNA double-strand break formation. Acts upstream of or within homologous chromosome pairing at meiosis; oogenesis; and spermatogenesis. Located in lateral element. Is expressed in spermatocyte. Orthologous to human MEI4 (meiotic double-stranded break formation protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Mei4 in Genome Data Viewer
Location:
9 E1; 9 44.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (81745723..82088060)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (81863670..82206007)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D430036J16 gene Neighboring gene STARR-seq mESC enhancer starr_24767 Neighboring gene STARR-seq mESC enhancer starr_24768 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1B Neighboring gene predicted gene, 53506 Neighboring gene SET nuclear oncogene pseudogene Neighboring gene STARR-seq mESC enhancer starr_24769 Neighboring gene STARR-seq mESC enhancer starr_24770 Neighboring gene STARR-seq mESC enhancer starr_24771 Neighboring gene STARR-seq mESC enhancer starr_24772 Neighboring gene STARR-seq mESC enhancer starr_24773 Neighboring gene STARR-seq mESC enhancer starr_24774 Neighboring gene STARR-seq mESC enhancer starr_24775 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene Neighboring gene RIKEN cDNA 1700063H06 gene Neighboring gene predicted gene, 23748 Neighboring gene predicted gene, 35548

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in oogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lateral element IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
meiosis-specific protein MEI4
Names
UPF0623 protein
meiosis-specific, MEI4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357477.1NP_001344406.1  meiosis-specific protein MEI4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC140070, AC163294, AK082395
    Consensus CDS
    CCDS90635.1
    Related
    ENSMUSP00000140647.2, ENSMUST00000189832.7
    Conserved Domains (1) summary
    pfam13971
    Location:2300
    Mei4; Meiosis-specific protein Mei4
  2. NM_001357479.1NP_001344408.1  meiosis-specific protein MEI4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC122931, AC132430, AC163294
    Consensus CDS
    CCDS90636.1
    UniProtKB/TrEMBL
    A0A087WP18, Q3TM14
    Related
    ENSMUSP00000139589.2, ENSMUST00000189391.2
    Conserved Domains (1) summary
    pfam13971
    Location:4278
    Mei4; Meiosis-specific protein Mei4
  3. NM_175213.4NP_780422.1  meiosis-specific protein MEI4 isoform 1

    See identical proteins and their annotated locations for NP_780422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122931, AC163294, AK043929
    Consensus CDS
    CCDS23371.1
    UniProtKB/Swiss-Prot
    Q4V9Z7, Q8BRM6, Q8C4E8
    UniProtKB/TrEMBL
    Q3TM14
    Related
    ENSMUSP00000061341.3, ENSMUST00000057067.10
    Conserved Domains (1) summary
    pfam13971
    Location:1377
    Mei4; Meiosis-specific protein Mei4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    81745723..82088060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)