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MEI4 meiotic double-stranded break formation protein 4 [ Homo sapiens (human) ]

Gene ID: 101928601, updated on 5-Aug-2022

Summary

Official Symbol
MEI4provided by HGNC
Official Full Name
meiotic double-stranded break formation protein 4provided by HGNC
Primary source
HGNC:HGNC:43638
See related
Ensembl:ENSG00000269964 MIM:618417; AllianceGenome:HGNC:43638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in gamete generation and meiosis I cell cycle process. Predicted to be active in lateral element. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 2.5), testis (RPKM 1.9) and 6 other tissues See more
Orthologs
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Genomic context

See MEI4 in Genome Data Viewer
Location:
6q14.1
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (77650274..77927045)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (78827553..79104425)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (78359991..78636762)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377864 Neighboring gene uncharacterized LOC124901493 Neighboring gene 5-hydroxytryptamine receptor 1B Neighboring gene ribosomal protein S6 pseudogene 7 Neighboring gene uncharacterized LOC105377865 Neighboring gene microRNA 10524 Neighboring gene uncharacterized LOC107986613

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic DNA double-strand break formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in lateral element IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lateral element ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
meiosis-specific protein MEI4
Names
meiosis-specific 4 homolog
meiosis-specific protein MEI4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282136.3NP_001269065.1  meiosis-specific protein MEI4

    See identical proteins and their annotated locations for NP_001269065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL590785, AL591027, AL591500, CA841124
    Consensus CDS
    CCDS64463.1
    UniProtKB/Swiss-Prot
    A8MW99, R4GMV8
    Related
    ENSP00000473370.1, ENST00000602452.3
    Conserved Domains (1) summary
    pfam13971
    Location:1377
    Mei4; Meiosis-specific protein Mei4
  2. NM_001322247.2NP_001309176.1  meiosis-specific protein MEI4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL590785, AL591027, AL591500, CA841124
    Consensus CDS
    CCDS64463.1
    UniProtKB/Swiss-Prot
    A8MW99, R4GMV8
    Related
    ENSP00000507827.1, ENST00000684080.1
    Conserved Domains (1) summary
    pfam13971
    Location:1377
    Mei4; Meiosis-specific protein Mei4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    77650274..77927045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010155.2XP_016865644.1  meiosis-specific protein MEI4 isoform X1

  2. XM_005248774.5XP_005248831.1  meiosis-specific protein MEI4 isoform X2

    Conserved Domains (1) summary
    pfam13971
    Location:14279
    Mei4; Meiosis-specific protein Mei4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    78827553..79104425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)