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Mdga1 MAM domain containing glycosylphosphatidylinositol anchor 1 [ Mus musculus (house mouse) ]

Gene ID: 74762, updated on 8-Feb-2024

Summary

Official Symbol
Mdga1provided by MGI
Official Full Name
MAM domain containing glycosylphosphatidylinositol anchor 1provided by MGI
Primary source
MGI:MGI:1922012
See related
Ensembl:ENSMUSG00000043557 AllianceGenome:MGI:1922012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPIM; Mamdc3; 1200011I03Rik
Summary
Involved in neuron migration. Acts upstream of or within cerebral cortex radially oriented cell migration. Predicted to be located in Golgi apparatus; membrane raft; and plasma membrane. Predicted to be anchored component of plasma membrane. Predicted to be active in GABA-ergic synapse. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human MDGA1 (MAM domain containing glycosylphosphatidylinositol anchor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 10.3), CNS E14 (RPKM 9.8) and 13 other tissues See more
Orthologs
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Genomic context

See Mdga1 in Genome Data Viewer
Location:
17 A3.3; 17 15.54 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (30046930..30107557, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29827956..29888583, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 28043 Neighboring gene predicted gene, 20161 Neighboring gene STARR-positive B cell enhancer ABC_E1501 Neighboring gene cap methyltransferase 1 Neighboring gene coiled-coil domain containing 167 Neighboring gene STARR-positive B cell enhancer ABC_E7510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29906709-29906939 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29978669-29978970 Neighboring gene STARR-seq mESC enhancer starr_42296 Neighboring gene STARR-seq mESC enhancer starr_42297 Neighboring gene STARR-seq mESC enhancer starr_42299 Neighboring gene predicted gene, 41559 Neighboring gene STARR-seq mESC enhancer starr_42301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:30116968-30117151 Neighboring gene predicted gene, 22327 Neighboring gene zinc finger, AN1-type domain 3 Neighboring gene predicted gene, 53994

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MAM domain-containing glycosylphosphatidylinositol anchor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081160.1NP_001074629.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001074629.1

    Status: VALIDATED

    Source sequence(s)
    AC151294, AC154291
    Consensus CDS
    CCDS37540.1
    UniProtKB/TrEMBL
    D3Z499
    Related
    ENSMUSP00000073246.6, ENSMUST00000073556.12
    Conserved Domains (6) summary
    cd06263
    Location:746909
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    cd00096
    Location:153217
    Ig; Immunoglobulin domain
    smart00408
    Location:254315
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:248326
    IG_like; Immunoglobulin like
    pfam00629
    Location:746910
    MAM; MAM domain, meprin/A5/mu
    cl11960
    Location:56115
    Ig; Immunoglobulin domain
  2. NM_001368423.1NP_001355352.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151294, AC154291
    Consensus CDS
    CCDS89052.1
    UniProtKB/Swiss-Prot
    E9PY95, E9QP80, Q0PMG2
    Related
    ENSMUSP00000126529.2, ENSMUST00000171691.9
    Conserved Domains (5) summary
    smart00409
    Location:248326
    IG; Immunoglobulin
    pfam00629
    Location:754918
    MAM; MAM domain, meprin/A5/mu
    pfam07679
    Location:333418
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:538620
    Ig_3; Immunoglobulin domain
    cl11960
    Location:56115
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    30046930..30107557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525041.5XP_006525104.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform X1

    Conserved Domains (5) summary
    smart00409
    Location:248326
    IG; Immunoglobulin
    smart00410
    Location:450535
    IG_like; Immunoglobulin like
    pfam00629
    Location:754890
    MAM; MAM domain, meprin/A5/mu
    pfam13927
    Location:132217
    Ig_3; Immunoglobulin domain
    cl11960
    Location:56115
    Ig; Immunoglobulin domain

RNA

  1. XR_003952203.2 RNA Sequence

  2. XR_385376.5 RNA Sequence

  3. XR_003952202.2 RNA Sequence

  4. XR_385375.5 RNA Sequence