Setmar SET domain without mariner transposase fusion [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Setmarprovided by MGI
Official Full Name: SET domain without mariner transposase fusionprovided by MGI
Primary source: MGI:MGI:1921979
See related: Ensembl:ENSMUSG00000034639 AllianceGenome:MGI:1921979
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Etet2; 5830404F24Rik
Summary: This gene encodes a histone-lysine N-methyltransferase that may be involved in the methylation of histone H3. In anthropoid primates this gene is a fusion gene of a SET histone-lysine N-methyltransferase and a mariner (MAR) family transposase. In all other species this gene contains only the SET domain. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in bladder adult (RPKM 2.7), frontal lobe adult (RPKM 1.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E1; 6 49.71 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (108042006..108054088)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (108065045..108077127)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The suppression of Notch-1 led to increased expression of Oct4 and Sox2, but in decreased gene expression of cMET, Setmar and CD44.
Title: Study of the interaction among Notch pathway receptors, correlation with stemness, as well as their interaction with CD44, dipeptidyl peptidase-IV, hepatocyte growth factor receptor and the SETMAR transferase, in colon cancer stem cells.
Metnase may have been selected for because it has a function opposing transposases and may thus play a key role in suppressing translocations that underlie oncogenicity.
Title: The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA topoisomerase binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	ISO Inferred from Sequence Orthology more info
enables histone H3K36 dimethyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K36 dimethyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K4 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K4 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K9 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in DNA double-strand break processing	ISO Inferred from Sequence Orthology more info
involved_in DNA integration	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in mitotic DNA integrity checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in nucleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
colocalizes_with condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase SETMAR

Names: SET domain and mariner transposase fusion gene-containing protein homolog; SET domain without mariner transposase fusion protein; epidermal tumor expressed transcript 2

NP_001263285.1

EC 2.1.1.357

NP_848478.2

EC 2.1.1.357

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276356.1 → NP_001263285.1 histone-lysine N-methyltransferase SETMAR isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate internal exon, compared to variant 1. This difference results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC153916

Conserved Domains (1) summary

cd10544
Location:19 → 269

SET_SETMAR; SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins
NM_178391.4 → NP_848478.2 histone-lysine N-methyltransferase SETMAR isoform 1

See identical proteins and their annotated locations for NP_848478.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC153916, AK017895

Consensus CDS

CCDS51867.1

UniProtKB/Swiss-Prot

E9QLD6, Q80UJ9

Related

ENSMUSP00000048225.6, ENSMUST00000049246.7

Conserved Domains (2) summary

smart00317
Location:142 → 269

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam05033
Location:29 → 132

Pre-SET; Pre-SET motif