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Setmar SET domain without mariner transposase fusion [ Mus musculus (house mouse) ]

Gene ID: 74729, updated on 12-May-2024

Summary

Official Symbol
Setmarprovided by MGI
Official Full Name
SET domain without mariner transposase fusionprovided by MGI
Primary source
MGI:MGI:1921979
See related
Ensembl:ENSMUSG00000034639 AllianceGenome:MGI:1921979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etet2; 5830404F24Rik
Summary
This gene encodes a histone-lysine N-methyltransferase that may be involved in the methylation of histone H3. In anthropoid primates this gene is a fusion gene of a SET histone-lysine N-methyltransferase and a mariner (MAR) family transposase. In all other species this gene contains only the SET domain. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in bladder adult (RPKM 2.7), frontal lobe adult (RPKM 1.9) and 28 other tissues See more
Orthologs
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Genomic context

See Setmar in Genome Data Viewer
Location:
6 E1; 6 49.71 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (108042006..108054088)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (108065045..108077127)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 38 Neighboring gene ARP1 actin-related protein 1 homolog B, centractin beta pseudogene Neighboring gene STARR-seq mESC enhancer starr_16948 Neighboring gene STARR-seq mESC enhancer starr_16949 Neighboring gene STARR-positive B cell enhancer ABC_E9097 Neighboring gene STARR-positive B cell enhancer ABC_E2198 Neighboring gene STARR-positive B cell enhancer ABC_E6463 Neighboring gene sulfatase modifying factor 1 Neighboring gene ribosomal protein L36, pseudogene 12 Neighboring gene STARR-positive B cell enhancer ABC_E6464 Neighboring gene STARR-positive B cell enhancer ABC_E6465 Neighboring gene STARR-positive B cell enhancer ABC_E2199 Neighboring gene predicted gene, 38872

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA topoisomerase binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H3K36 dimethyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H3K36 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H3K4 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with condensed chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone-lysine N-methyltransferase SETMAR
Names
SET domain and mariner transposase fusion gene-containing protein homolog
SET domain without mariner transposase fusion protein
epidermal tumor expressed transcript 2
NP_001263285.1
NP_848478.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276356.1NP_001263285.1  histone-lysine N-methyltransferase SETMAR isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate internal exon, compared to variant 1. This difference results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC153916
    Conserved Domains (1) summary
    cd10544
    Location:19269
    SET_SETMAR; SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins
  2. NM_178391.4NP_848478.2  histone-lysine N-methyltransferase SETMAR isoform 1

    See identical proteins and their annotated locations for NP_848478.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC153916, AK017895
    Consensus CDS
    CCDS51867.1
    UniProtKB/Swiss-Prot
    E9QLD6, Q80UJ9
    Related
    ENSMUSP00000048225.6, ENSMUST00000049246.7
    Conserved Domains (2) summary
    smart00317
    Location:142269
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam05033
    Location:29132
    Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    108042006..108054088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)