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Tdrd9 tudor domain containing 9 [ Mus musculus (house mouse) ]

Gene ID: 74691, updated on 21-Apr-2024

Summary

Official Symbol
Tdrd9provided by MGI
Official Full Name
tudor domain containing 9provided by MGI
Primary source
MGI:MGI:1921941
See related
Ensembl:ENSMUSG00000054003 AllianceGenome:MGI:1921941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930441E05Rik
Summary
Predicted to enable RNA binding activity. Involved in fertilization; gamete generation; and piRNA metabolic process. Acts upstream of or within negative regulation of transposition. Located in nucleus and piP-body. Is expressed in germ cell of testis. Human ortholog(s) of this gene implicated in spermatogenic failure 30. Orthologous to human TDRD9 (tudor domain containing 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 20.7) See more
Orthologs
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Genomic context

Location:
12 F1; 12 61.14 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111937922..112035288)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111971488..112068854)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36757 Neighboring gene STARR-positive B cell enhancer ABC_E8504 Neighboring gene ATP synthase membrane subunit j Neighboring gene retinal degeneration 3-like Neighboring gene predicted gene, 46381 Neighboring gene microRNA 3073a Neighboring gene microRNA 3073b Neighboring gene asparaginase Neighboring gene microRNA 203b Neighboring gene microRNA 203

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in piP-body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-dependent RNA helicase TDRD9
Names
putative ATP-dependent RNA helicase TDRD9
tudor domain-containing protein 9
NP_083332.1
XP_006516379.1
XP_006516380.1
XP_006516382.1
XP_006516383.1
XP_006516384.1
XP_006516385.1
XP_017170707.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029056.1NP_083332.1  ATP-dependent RNA helicase TDRD9

    See identical proteins and their annotated locations for NP_083332.1

    Status: VALIDATED

    Source sequence(s)
    AB362563
    Consensus CDS
    CCDS49184.1
    UniProtKB/Swiss-Prot
    B1Q3J8, Q14AW6, Q14BI7
    Related
    ENSMUSP00000078022.6, ENSMUST00000079009.11
    Conserved Domains (2) summary
    COG1643
    Location:111717
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd20431
    Location:9061006
    Tudor_TDRD9; Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111937922..112035288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315218.2XP_017170707.1  ATP-dependent RNA helicase TDRD9 isoform X7

    Conserved Domains (1) summary
    COG1643
    Location:111717
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  2. XM_006516317.5XP_006516380.1  ATP-dependent RNA helicase TDRD9 isoform X2

    Conserved Domains (2) summary
    COG1643
    Location:111717
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:9051014
    TUDOR; Tudor domain
  3. XM_006516316.3XP_006516379.1  ATP-dependent RNA helicase TDRD9 isoform X1

    Conserved Domains (2) summary
    COG1643
    Location:111680
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:887996
    TUDOR; Tudor domain
  4. XM_006516320.4XP_006516383.1  ATP-dependent RNA helicase TDRD9 isoform X4

    Conserved Domains (2) summary
    COG1643
    Location:111695
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:812921
    TUDOR; Tudor domain
  5. XM_006516319.3XP_006516382.1  ATP-dependent RNA helicase TDRD9 isoform X3

    Conserved Domains (2) summary
    COG1643
    Location:38644
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:832941
    TUDOR; Tudor domain
  6. XM_006516321.3XP_006516384.1  ATP-dependent RNA helicase TDRD9 isoform X5

    See identical proteins and their annotated locations for XP_006516384.1

    UniProtKB/Swiss-Prot
    Q14BI7
    Conserved Domains (2) summary
    COG1643
    Location:13316
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:504613
    TUDOR; Tudor domain
  7. XM_006516322.1XP_006516385.1  ATP-dependent RNA helicase TDRD9 isoform X6

    Conserved Domains (2) summary
    TIGR01967
    Location:1186
    DEAH_box_HrpA; RNA helicase HrpA
    pfam00567
    Location:379488
    TUDOR; Tudor domain

RNA

  1. XR_381553.4 RNA Sequence

  2. XR_003950089.1 RNA Sequence