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TDRD9 tudor domain containing 9 [ Homo sapiens (human) ]

Gene ID: 122402, updated on 8-Jul-2021

Summary

Official Symbol
TDRD9provided by HGNC
Official Full Name
tudor domain containing 9provided by HGNC
Primary source
HGNC:HGNC:20122
See related
Ensembl:ENSG00000156414 MIM:617963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLS; SPNE; HIG-1; NET54; SPGF30; C14orf75
Expression
Biased expression in testis (RPKM 26.4) and thyroid (RPKM 5.7) See more
Orthologs
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Genomic context

See TDRD9 in Genome Data Viewer
Location:
14q32.33
Exon count:
39
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (103928343..104052667)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104394793..104519004)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370690 Neighboring gene uncharacterized LOC105370689 Neighboring gene ATP synthase membrane subunit j Neighboring gene RD3 like Neighboring gene RNA, 7SL, cytoplasmic 634, pseudogene Neighboring gene asparaginase Neighboring gene microRNA 203a Neighboring gene microRNA 203b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
GeneReviews: Not available
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
GeneReviews: Not available
Spermatogenic failure 30
MedGen: C4748224 OMIM: 618110 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36164, MGC135025, DKFZp434N0820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA methylation involved in gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gene silencing by RNA IEA
Inferred from Electronic Annotation
more info
 
involved_in male meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in male meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transposition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transposition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in piRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in piP-body ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase TDRD9
Names
hypoxia-inducible HIG-1
putative ATP-dependent RNA helicase TDRD9
tudor domain-containing protein 9
NP_694591.2
XP_005267366.1
XP_006720082.1
XP_006720083.1
XP_011534699.1
XP_011534700.1
XP_011534702.1
XP_011534703.1
XP_011534704.1
XP_016876444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153046.3NP_694591.2  ATP-dependent RNA helicase TDRD9

    See identical proteins and their annotated locations for NP_694591.2

    Status: VALIDATED

    Source sequence(s)
    AL132712, AL136001
    Consensus CDS
    CCDS9987.2
    UniProtKB/Swiss-Prot
    Q8NDG6
    UniProtKB/TrEMBL
    Q86WA0
    Related
    ENSP00000387303.4, ENST00000409874.9
    Conserved Domains (6) summary
    cd04508
    Location:949996
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00847
    Location:588665
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:132716
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:149290
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:383500
    Helicase_C; Helicase conserved C-terminal domain
    pfam00567
    Location:9041013
    TUDOR; Tudor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    103928343..104052667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720019.3XP_006720082.1  ATP-dependent RNA helicase TDRD9 isoform X1

    Conserved Domains (6) summary
    cd04508
    Location:949996
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00847
    Location:588665
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:132716
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:149290
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:383500
    Helicase_C; Helicase conserved C-terminal domain
    pfam00567
    Location:9041013
    TUDOR; Tudor domain
  2. XM_005267309.4XP_005267366.1  ATP-dependent RNA helicase TDRD9 isoform X5

    Conserved Domains (6) summary
    cd04508
    Location:949996
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00847
    Location:588665
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:132716
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:149290
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:383500
    Helicase_C; Helicase conserved C-terminal domain
    pfam00567
    Location:9041013
    TUDOR; Tudor domain
  3. XM_011536397.2XP_011534699.1  ATP-dependent RNA helicase TDRD9 isoform X3

    Conserved Domains (6) summary
    cd04508
    Location:914961
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00847
    Location:553630
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:132681
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:149290
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:383465
    Helicase_C; Helicase conserved C-terminal domain
    pfam00567
    Location:869978
    TUDOR; Tudor domain
  4. XM_011536400.2XP_011534702.1  ATP-dependent RNA helicase TDRD9 isoform X6

    Conserved Domains (5) summary
    cd04508
    Location:862909
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00847
    Location:501578
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:132629
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:149290
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00567
    Location:817926
    TUDOR; Tudor domain
  5. XM_006720020.3XP_006720083.1  ATP-dependent RNA helicase TDRD9 isoform X2

    Conserved Domains (6) summary
    cd04508
    Location:922969
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00847
    Location:561638
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:132689
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:149263
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:356473
    Helicase_C; Helicase conserved C-terminal domain
    pfam00567
    Location:877986
    TUDOR; Tudor domain
  6. XM_017020955.2XP_016876444.1  ATP-dependent RNA helicase TDRD9 isoform X9

  7. XM_011536398.3XP_011534700.1  ATP-dependent RNA helicase TDRD9 isoform X4

    Conserved Domains (6) summary
    cd04508
    Location:911958
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00847
    Location:550627
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:94678
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:111252
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:345462
    Helicase_C; Helicase conserved C-terminal domain
    pfam00567
    Location:866975
    TUDOR; Tudor domain
  8. XM_011536401.3XP_011534703.1  ATP-dependent RNA helicase TDRD9 isoform X7

    Conserved Domains (5) summary
    cd04508
    Location:720767
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00847
    Location:359436
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:161
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:154271
    Helicase_C; Helicase conserved C-terminal domain
    pfam00567
    Location:675784
    TUDOR; Tudor domain
  9. XM_011536402.2XP_011534704.1  ATP-dependent RNA helicase TDRD9 isoform X8

    Conserved Domains (4) summary
    cd04508
    Location:587634
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    smart00847
    Location:226303
    HA2; Helicase associated domain (HA2) Add an annotation
    pfam00271
    Location:21138
    Helicase_C; Helicase conserved C-terminal domain
    pfam00567
    Location:542651
    TUDOR; Tudor domain
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