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Brme1 break repair meiotic recombinase recruitment factor 1 [ Mus musculus (house mouse) ]

Gene ID: 74666, updated on 2-Nov-2024

Summary

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Official Symbol
Brme1provided by MGI
Official Full Name
break repair meiotic recombinase recruitment factor 1provided by MGI
Primary source
MGI:MGI:1921916
See related
Ensembl:ENSMUSG00000008129 AllianceGenome:MGI:1921916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRM; Mamerr; Meiok21; 4930432K21Rik
Summary
Enables damaged DNA binding activity. Involved in meiosis I; protein localization to site of double-strand break; and spermatogenesis. Located in chromosome. Is active in site of double-strand break. Is expressed in several structures, including 4th ventricle choroid plexus; genitourinary system; meninges; nasal epithelium; and thoracic segment skeleton. Orthologous to human BRME1 (break repair meiotic recombinase recruitment factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 23.7) and ovary adult (RPKM 2.1) See more
Orthologs
human all
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Genomic context

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See Brme1 in Genome Data Viewer
Location:
8 C2; 8 40.35 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84874637..84899220)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84148008..84172597)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39210 Neighboring gene DDB1 and CUL4 associated factor 15 Neighboring gene STARR-positive B cell enhancer mm9_chr8:86628640-86628941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86650788-86650941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86651237-86651346 Neighboring gene podocan-like 1 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene nanos C2HC-type zinc finger 3 Neighboring gene microRNA 181d Neighboring gene microRNA 181c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MEIOK21 regulates oocyte quantity and quality via modulating meiotic recombination. Shang Y, et al. FASEB J, 2022 Jun. PMID 35593531
  2. The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I. Li M, et al. J Genet Genomics, 2020 Aug. PMID 33250349
  3. MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis. Shang Y, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32463460, Free PMC Article
  4. Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination. Takemoto K, et al. Cell Rep, 2020 May 26. PMID 32460033
  5. The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. Zhang J, et al. Nat Commun, 2020 Apr 28. PMID 32345962, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I.
    Title: The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I.
  2. A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
    Title: A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
  3. BRCA2 binds to the C-terminus of MEILB2, resulting in the formation of the BRCA2-MEILB2-BRME1 ternary complex.
    Title: The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair involved in meiotic recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in female meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reciprocal meiotic recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
break repair meiotic recombinase recruitment factor 1
Names
BRCA2 and MEILB2-associating protein 1
meiotic recombination modulator
uncharacterized protein C19orf57 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163752.2 → NP_001157224.1  break repair meiotic recombinase recruitment factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001157224.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC159266
    Consensus CDS
    CCDS52617.1
    UniProtKB/TrEMBL
    A0A6F8PYC8
    Related
    ENSMUSP00000091067.5, ENSMUST00000093375.5
    Conserved Domains (1) summary
    pfam15710
    Location:1 → 565
    DUF4671; Domain of unknown function (DUF4671)

  2. NM_029045.3 → NP_083321.2  break repair meiotic recombinase recruitment factor 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159266
    Consensus CDS
    CCDS52616.1
    UniProtKB/Swiss-Prot
    A0A0R4J144, E9QNR8, Q6DIA7, Q9D5J2
    UniProtKB/TrEMBL
    A0A6F8PYC8
    Related
    ENSMUSP00000113651.2, ENSMUST00000118856.8
    Conserved Domains (1) summary
    pfam15710
    Location:1 → 600
    DUF4671; Domain of unknown function (DUF4671)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84874637..84899220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243821.1 → XP_030099681.1  break repair meiotic recombinase recruitment factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A6F8PYC8
    Conserved Domains (1) summary
    pfam15710
    Location:1 → 570
    DUF4671; Domain of unknown function (DUF4671)

  2. XM_006531445.4 → XP_006531508.1  break repair meiotic recombinase recruitment factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006531508.1

    UniProtKB/TrEMBL
    A0A6F8PYC8
    Conserved Domains (1) summary
    pfam15710
    Location:1 → 570
    DUF4671; Domain of unknown function (DUF4671)

  3. XM_030243822.1 → XP_030099682.1  break repair meiotic recombinase recruitment factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A6F8PYC8
    Conserved Domains (1) summary
    pfam15710
    Location:4 → 535
    DUF4671; Domain of unknown function (DUF4671)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DIA7.2 GenPept UniProtKB/Swiss-Prot:Q6DIA7

Gene LinkOut

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