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CORO2A coronin 2A [ Homo sapiens (human) ]

Gene ID: 7464, updated on 8-Oct-2017
Official Symbol
CORO2Aprovided by HGNC
Official Full Name
coronin 2Aprovided by HGNC
Primary source
HGNC:HGNC:2255
See related
Ensembl:ENSG00000106789 MIM:602159; Vega:OTTHUMG00000020340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IR10; WDR2; CLIPINB
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Orthologs
Location:
9q22.33
Exon count:
14
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (98120975..98192674, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100883257..100954956, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 918, pseudogene Neighboring gene N-acetylneuraminate synthase Neighboring gene tripartite motif containing 14 Neighboring gene TBC1 domain family member 2 Neighboring gene ADP ribosylation factor like GTPase 8B pseudogene Neighboring gene microRNA 6854

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686G19226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
coronin-2A
Names
WD protein IR10
WD repeat-containing protein 2
WD-repeat protein 2
coronin, actin binding protein, 2A
coronin-like protein B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003389.3NP_003380.3  coronin-2A

    See identical proteins and their annotated locations for NP_003380.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains a distinct 5' UTR transcribed from an alternate exon, as compared to variant 2. Variants 1 and 2 encode the same protein and contain the same 3' UTR.
    Source sequence(s)
    AK292788, AL137073, BM822208, BM976925
    Consensus CDS
    CCDS6735.1
    UniProtKB/Swiss-Prot
    Q92828
    UniProtKB/TrEMBL
    A0A024R150, A8K9S3
    Related
    ENSP00000343746.5, OTTHUMP00000021767, ENST00000343933.9, OTTHUMT00000053357
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10518
    WD40_4; Type of WD40 repeat
  2. NM_052820.3NP_438171.1  coronin-2A

    See identical proteins and their annotated locations for NP_438171.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR transcribed from an alternate exon, as compared to variant 1. Variants 1 and 2 encode the same protein and contain the same 3' UTR.
    Source sequence(s)
    AK292788, AL137073, BC011690, BM976925, DB459852
    Consensus CDS
    CCDS6735.1
    UniProtKB/Swiss-Prot
    Q92828
    UniProtKB/TrEMBL
    A0A024R150, A8K9S3
    Related
    ENSP00000364218.4, OTTHUMP00000021768, ENST00000375077.4, OTTHUMT00000053358
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10518
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

    Range
    98120975..98192674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518986.2XP_011517288.1  coronin-2A isoform X1

    See identical proteins and their annotated locations for XP_011517288.1

    UniProtKB/Swiss-Prot
    Q92828
    UniProtKB/TrEMBL
    A0A024R150
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10518
    WD40_4; Type of WD40 repeat

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    101029674..101101387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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