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TMEM258 transmembrane protein 258 [ Homo sapiens (human) ]

Gene ID: 746, updated on 2-Mar-2021


Official Symbol
TMEM258provided by HGNC
Official Full Name
transmembrane protein 258provided by HGNC
Primary source
See related
Ensembl:ENSG00000134825 MIM:617615
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Kud; Kuduk; C11orf10
Ubiquitous expression in colon (RPKM 77.0), stomach (RPKM 64.2) and 25 other tissues See more
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Genomic context

See TMEM258 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (61788949..61792599, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61556421..61560071, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene diacylglycerol lipase alpha Neighboring gene Sharpr-MPRA regulatory region 11353 Neighboring gene MYRF antisense RNA 1 Neighboring gene myelin regulatory factor Neighboring gene microRNA 611 Neighboring gene flap structure-specific endonuclease 1 Neighboring gene fatty acid desaturase 1 Neighboring gene microRNA 1908

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
A genome-wide association study of the metabolic syndrome in Indian Asian men.
GeneReviews: Not available
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
GeneReviews: Not available
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
GeneReviews: Not available
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
GeneReviews: Not available
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
GeneReviews: Not available
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
GeneReviews: Not available
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
GeneReviews: Not available


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
integral component of membrane IEA
Inferred from Electronic Annotation
more info
membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
oligosaccharyltransferase I complex IDA
Inferred from Direct Assay
more info
protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
transmembrane protein 258
UPF0197 transmembrane protein C11orf10
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
oligosaccharyl transferase subunit TMEM258

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014206.4NP_055021.1  transmembrane protein 258

    See identical proteins and their annotated locations for NP_055021.1

    Status: VALIDATED

    Source sequence(s)
    AF085986, AP002380, BC015968
    Consensus CDS
    ENSP00000443216.1, ENST00000537328.6
    Conserved Domains (1) summary
    Ost5; Oligosaccharyltransferase subunit 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    61788949..61792599 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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