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Tnks2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 [ Mus musculus (house mouse) ]

Gene ID: 74493, updated on 9-May-2024

Summary

Official Symbol
Tnks2provided by MGI
Official Full Name
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2provided by MGI
Primary source
MGI:MGI:1921743
See related
Ensembl:ENSMUSG00000024811 AllianceGenome:MGI:1921743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTD6; Tank2; Parp5b; TNKS-2; 5430432P15Rik
Summary
Predicted to enable enzyme binding activity; pentosyltransferase activity; and protein N-terminus binding activity. Acts upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 24.7), CNS E11.5 (RPKM 20.9) and 28 other tissues See more
Orthologs
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Genomic context

See Tnks2 in Genome Data Viewer
Location:
19 C2; 19 31.96 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (36811583..36870877)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (36834129..36893477)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3C Neighboring gene STARR-seq mESC enhancer starr_46030 Neighboring gene predicted gene, 57662 Neighboring gene STARR-seq mESC enhancer starr_46034 Neighboring gene VISTA enhancer mm1641 Neighboring gene STARR-seq mESC enhancer starr_46037 Neighboring gene STARR-positive B cell enhancer ABC_E11029 Neighboring gene STARR-seq mESC enhancer starr_46040 Neighboring gene STARR-positive B cell enhancer ABC_E4277 Neighboring gene STARR-seq mESC enhancer starr_46041 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (7)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
involved_in protein poly-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within telomere maintenance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
poly [ADP-ribose] polymerase tankyrase-2
Names
ADP-ribosyltransferase diphtheria toxin-like 6
TRF1-interacting ankyrin-related ADP-ribose polymerase 2
protein poly-ADP-ribosyltransferase tankyrase-2
tankyrase II
tankyrase-2
tankyrase-like protein
tankyrase-related protein
NP_001157107.1
XP_006527471.1
XP_006527472.1
XP_011245684.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163635.1NP_001157107.1  poly [ADP-ribose] polymerase tankyrase-2

    See identical proteins and their annotated locations for NP_001157107.1

    Status: VALIDATED

    Source sequence(s)
    AK047094, AK149368, AK163335, BC063101, BY710137, CN531910
    Consensus CDS
    CCDS50426.1
    UniProtKB/Swiss-Prot
    Q3UES3, Q6P537, Q8BXH7
    UniProtKB/TrEMBL
    A0AA74KUV1
    Related
    ENSMUSP00000025729.6, ENSMUST00000025729.12
    Conserved Domains (8) summary
    cd09524
    Location:871936
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:877933
    SAM; Sterile alpha motif
    cd00204
    Location:518643
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:9381160
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00644
    Location:9521155
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:530622
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2878
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:528556
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    36811583..36870877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247382.3XP_011245684.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

    Conserved Domains (4) summary
    PTZ00322
    Location:27113
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02876
    Location:73458
    PHA02876; ankyrin repeat protein; Provisional
    PHA03095
    Location:494784
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:528556
    ANK; ANK repeat [structural motif]
  2. XM_006527409.5XP_006527472.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

    UniProtKB/TrEMBL
    A0AA74KUV1
    Conserved Domains (5) summary
    PTZ00322
    Location:27113
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02876
    Location:73458
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:808873
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    cd01438
    Location:8751097
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:528556
    ANK; ANK repeat [structural motif]
  3. XM_006527408.5XP_006527471.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

    UniProtKB/TrEMBL
    A0AA74KUV1
    Conserved Domains (5) summary
    cd09524
    Location:814879
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:437745
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:8811103
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:471499
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:248404
    Ank_2; Ankyrin repeats (3 copies)