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TNKS2 tankyrase 2 [ Homo sapiens (human) ]

Gene ID: 80351, updated on 6-Sep-2021

Summary

Official Symbol
TNKS2provided by HGNC
Official Full Name
tankyrase 2provided by HGNC
Primary source
HGNC:HGNC:15677
See related
Ensembl:ENSG00000107854 MIM:607128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c
Expression
Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues See more
Orthologs
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Genomic context

See TNKS2 in Genome Data Viewer
Location:
10q23.32
Exon count:
31
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (91798426..91865475)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93558183..93625232)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Fas associated factor family member 2 pseudogene 1 Neighboring gene TNKS2 divergent transcript Neighboring gene signal recognition particle 9 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 9903 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
involved_in positive regulation of telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of telomere capping IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere maintenance via telomerase IC
Inferred by Curator
more info
PubMed 
involved_in protein ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IC
Inferred by Curator
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
poly [ADP-ribose] polymerase tankyrase-2
Names
ADP-ribosyltransferase diphtheria toxin-like 6
TNKS-2
TRF1-interacting ankyrin-related ADP-ribose polymerase 2
poly [ADP-ribose] polymerase 5B
protein poly-ADP-ribosyltransferase tankyrase-2
tankyrase II
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
tankyrase-like protein
tankyrase-related protein
NP_079511.1
XP_005270242.2
XP_011538515.1
XP_011538517.1
XP_016872185.1
XP_016872186.1
XP_016872187.1
XP_016872188.1
XP_016872189.1
XP_016872190.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025235.4NP_079511.1  poly [ADP-ribose] polymerase tankyrase-2

    See identical proteins and their annotated locations for NP_079511.1

    Status: VALIDATED

    Source sequence(s)
    AF309033, AF438201, BQ019749
    Consensus CDS
    CCDS7417.1
    UniProtKB/Swiss-Prot
    Q9H2K2
    Related
    ENSP00000360689.4, ENST00000371627.5
    Conserved Domains (6) summary
    PHA02876
    Location:73458
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:871936
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:494802
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:9381160
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:528556
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:4396
    Ank_5; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    91798426..91865475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270185.4XP_005270242.2  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

    Conserved Domains (6) summary
    PHA02876
    Location:94479
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:895960
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:540826
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:9621184
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:552580
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:28142
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_011540213.1XP_011538515.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

    Conserved Domains (6) summary
    PHA02876
    Location:94479
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:892957
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:515823
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:9591181
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:549577
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:28142
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_017016697.1XP_016872186.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X4

    Conserved Domains (6) summary
    cd09524
    Location:767832
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:412698
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:8341056
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:424452
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:36134
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:100365
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_017016699.1XP_016872188.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X5

    Conserved Domains (5) summary
    cd09524
    Location:764829
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:387695
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:8311053
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:421449
    ANK; ANK repeat [structural motif]
    cl39094
    Location:100365
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_017016696.1XP_016872185.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

    Conserved Domains (6) summary
    PHA02876
    Location:73458
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:874939
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:519805
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:9411163
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:531559
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:4396
    Ank_5; Ankyrin repeats (many copies)
  6. XM_017016701.1XP_016872190.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X8

    Conserved Domains (3) summary
    PHA02876
    Location:94479
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:234262
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:28142
    Ank_2; Ankyrin repeats (3 copies)
  7. XM_017016698.2XP_016872187.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X4

    Conserved Domains (6) summary
    cd09524
    Location:767832
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:412698
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:8341056
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:424452
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:36134
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:100365
    Ank_2; Ankyrin repeats (3 copies)
  8. XM_017016700.2XP_016872189.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X6

    Conserved Domains (5) summary
    cd09524
    Location:682747
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:327613
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:749971
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:339367
    ANK; ANK repeat [structural motif]
    cl39094
    Location:15280
    Ank_2; Ankyrin repeats (3 copies)
  9. XM_011540215.2XP_011538517.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X7

    Conserved Domains (4) summary
    cd09524
    Location:400465
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:23331
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:467689
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:5785
    ANK; ANK repeat [structural motif]
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