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TNKS2 tankyrase 2 [ Homo sapiens (human) ]

Gene ID: 80351, updated on 1-Jun-2020

Summary

Official Symbol
TNKS2provided by HGNC
Official Full Name
tankyrase 2provided by HGNC
Primary source
HGNC:HGNC:15677
See related
Ensembl:ENSG00000107854 MIM:607128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c
Expression
Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues See more
Orthologs

Genomic context

See TNKS2 in Genome Data Viewer
Location:
10q23.32
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (91798426..91865475)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93558151..93625232)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Fas associated factor family member 2 pseudogene 1 Neighboring gene TNKS2 antisense RNA 1 (head to head) Neighboring gene signal recognition particle 9 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 9903 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of telomere capping IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance via telomerase IC
Inferred by Curator
more info
PubMed 
protein ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear chromosome, telomeric region IC
Inferred by Curator
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pericentriolar material IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
poly [ADP-ribose] polymerase tankyrase-2
Names
ADP-ribosyltransferase diphtheria toxin-like 6
TNKS-2
TRF1-interacting ankyrin-related ADP-ribose polymerase 2
poly [ADP-ribose] polymerase 5B
protein poly-ADP-ribosyltransferase tankyrase-2
tankyrase II
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
tankyrase-like protein
tankyrase-related protein
NP_079511.1
XP_005270242.2
XP_011538515.1
XP_011538517.1
XP_016872185.1
XP_016872186.1
XP_016872187.1
XP_016872188.1
XP_016872189.1
XP_016872190.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025235.4NP_079511.1  poly [ADP-ribose] polymerase tankyrase-2

    See identical proteins and their annotated locations for NP_079511.1

    Status: VALIDATED

    Source sequence(s)
    AF309033, AF438201, BQ019749
    Consensus CDS
    CCDS7417.1
    UniProtKB/Swiss-Prot
    Q9H2K2
    Related
    ENSP00000360689.4, ENST00000371627.5
    Conserved Domains (5) summary
    cd09524
    Location:871936
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    cd00204
    Location:518643
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:9381160
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:528556
    ANK; ANK repeat [structural motif]
    cl26073
    Location:207472
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    91798426..91865475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270185.4XP_005270242.2  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

  2. XM_011540213.1XP_011538515.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

    Conserved Domains (7) summary
    cd09524
    Location:892957
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:898954
    SAM; Sterile alpha motif
    cd00204
    Location:539664
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:9591181
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00644
    Location:9731176
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:551643
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:549577
    ANK; ANK repeat [structural motif]
  3. XM_017016697.1XP_016872186.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X4

  4. XM_017016699.1XP_016872188.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X5

    Conserved Domains (6) summary
    cd09524
    Location:764829
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    cd00204
    Location:411536
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:8311053
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:421449
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:36134
    Ank_2; Ankyrin repeats (3 copies)
    cl26073
    Location:100365
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_017016696.1XP_016872185.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

  6. XM_017016701.1XP_016872190.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X8

  7. XM_017016698.2XP_016872187.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X4

  8. XM_017016700.2XP_016872189.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X6

  9. XM_011540215.2XP_011538517.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X7

    Conserved Domains (8) summary
    cd09524
    Location:400465
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:406462
    SAM; Sterile alpha motif
    cd00204
    Location:47172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:467689
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00644
    Location:481684
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:59151
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2575
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:5785
    ANK; ANK repeat [structural motif]
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