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Tspan17 tetraspanin 17 [ Mus musculus (house mouse) ]

Gene ID: 74257, updated on 5-Mar-2024

Summary

Official Symbol
Tspan17provided by MGI
Official Full Name
tetraspanin 17provided by MGI
Primary source
MGI:MGI:1921507
See related
Ensembl:ENSMUSG00000025875 AllianceGenome:MGI:1921507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbxo23; Tm4sf17; 2210021G21Rik
Summary
Enables enzyme binding activity. Involved in protein maturation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; ganglia; neural retina; and ventral grey horn. Orthologous to human TSPAN17 (tetraspanin 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.8), cerebellum adult (RPKM 14.7) and 23 other tissues See more
Orthologs
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Genomic context

See Tspan17 in Genome Data Viewer
Location:
13 B1; 13 29.41 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54936915..54944588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54789102..54796775)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34592 Neighboring gene predicted gene 16249 Neighboring gene STARR-positive B cell enhancer mm9_chr13:54890539-54890840 Neighboring gene eukaryotic translation initiation factor 4E family member 1B Neighboring gene predicted gene, 40959 Neighboring gene predicted gene, 31188

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetraspanin-17
Names
F-box only protein 23
tetraspan protein SB134
transmembrane 4 superfamily member 17
tspan-17
NP_083117.2
XP_006517477.1
XP_006517478.1
XP_006517480.1
XP_017171106.1
XP_017171107.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028841.3NP_083117.2  tetraspanin-17

    See identical proteins and their annotated locations for NP_083117.2

    Status: VALIDATED

    Source sequence(s)
    AI019499, AK008761, BY734818, CD740983
    Consensus CDS
    CCDS26536.1
    UniProtKB/Swiss-Prot
    Q91VI6, Q9D7W4
    UniProtKB/TrEMBL
    Q3TAQ3
    Related
    ENSMUSP00000026993.8, ENSMUST00000026993.14
    Conserved Domains (2) summary
    cd03159
    Location:115235
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16263
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54936915..54944588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517414.3XP_006517477.1  tetraspanin-17 isoform X1

    See identical proteins and their annotated locations for XP_006517477.1

    UniProtKB/Swiss-Prot
    Q91VI6, Q9D7W4
    Related
    ENSMUSP00000115287.3, ENSMUST00000131692.9
    Conserved Domains (1) summary
    cd03159
    Location:115235
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  2. XM_006517415.3XP_006517478.1  tetraspanin-17 isoform X2

    UniProtKB/Swiss-Prot
    Q91VI6, Q9D7W4
    Conserved Domains (2) summary
    cd03159
    Location:115210
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:18191
    Tetraspannin; Tetraspanin family
  3. XM_017315617.2XP_017171106.1  tetraspanin-17 isoform X3

    UniProtKB/TrEMBL
    F6VW20
    Related
    ENSMUSP00000123607.3, ENSMUST00000130568.9
    Conserved Domains (2) summary
    cd03159
    Location:115194
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:18191
    Tetraspannin; Tetraspanin family
  4. XM_006517417.4XP_006517480.1  tetraspanin-17 isoform X5

    Conserved Domains (2) summary
    cl02781
    Location:115194
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:18191
    Tetraspannin; Tetraspanin family
  5. XM_017315618.2XP_017171107.1  tetraspanin-17 isoform X4

    UniProtKB/TrEMBL
    E9PWC3
    Related
    ENSMUSP00000131671.2, ENSMUST00000163796.8
    Conserved Domains (1) summary
    cd03159
    Location:49169
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RNA

  1. XR_382461.2 RNA Sequence