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TSPAN17 tetraspanin 17 [ Homo sapiens (human) ]

Gene ID: 26262, updated on 8-Oct-2017
Official Symbol
TSPAN17provided by HGNC
Official Full Name
tetraspanin 17provided by HGNC
Primary source
HGNC:HGNC:13594
See related
Ensembl:ENSG00000048140 Vega:OTTHUMG00000163230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX23; FBXO23; TM4SF17
Summary
This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014]
Orthologs
Location:
5q35.2
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (176647387..176659058)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176074388..176086059)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene microRNA 4281 Neighboring gene eukaryotic translation initiation factor 4E family member 1B Neighboring gene synuclein beta Neighboring gene long intergenic non-protein coding RNA 1574 Neighboring gene unc-5 netrin receptor A Neighboring gene hexokinase 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC14859, MGC71255

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
establishment of protein localization to organelle IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
tetraspanin-17
Names
F-box only protein 23, transmembrane 4 superfamily member 17
tetraspan protein SB134
NP_001006617.2
NP_036303.1
NP_569732.2
XP_005265933.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034043.1 RefSeqGene

    Range
    5001..16672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006616.2NP_001006617.2  tetraspanin-17 isoform c

    See identical proteins and their annotated locations for NP_001006617.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, and an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC091934, BC010405, BG703362, CA417292, CT002861
    Consensus CDS
    CCDS47346.2
    UniProtKB/Swiss-Prot
    Q96FV3
    Related
    ENSP00000426650.1, OTTHUMP00000223388, ENST00000515708.5, OTTHUMT00000372209
    Conserved Domains (2) summary
    cd03159
    Location:115235
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16259
    Tetraspannin; Tetraspanin family
  2. NM_012171.2NP_036303.1  tetraspanin-17 isoform a

    See identical proteins and their annotated locations for NP_036303.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC091934, CA417292
    Consensus CDS
    CCDS34298.1
    UniProtKB/TrEMBL
    J3KNG2
    Related
    ENSP00000309036.8, OTTHUMP00000223387, ENST00000310032.12, OTTHUMT00000372208
    Conserved Domains (2) summary
    cd03159
    Location:115238
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16266
    Tetraspannin; Tetraspanin family
  3. NM_130465.4NP_569732.2  tetraspanin-17 isoform b

    See identical proteins and their annotated locations for NP_569732.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC091934, BC067105, BG703362, CA417292, CT002861
    Consensus CDS
    CCDS54952.1
    UniProtKB/Swiss-Prot
    Q96FV3
    UniProtKB/TrEMBL
    A0A024R7Q6
    Related
    ENSP00000422053.1, OTTHUMP00000223389, ENST00000508164.5, OTTHUMT00000372210
    Conserved Domains (1) summary
    cd03159
    Location:115235
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

    Range
    176647387..176659058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265876.3XP_005265933.1  tetraspanin-17 isoform X1

    Conserved Domains (2) summary
    cd03159
    Location:49169
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:14197
    Tetraspannin; Tetraspanin family

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    175506822..175518493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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