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Lrrc2 leucine rich repeat containing 2 [ Mus musculus (house mouse) ]

Gene ID: 74249, updated on 8-Dec-2022

Summary

Official Symbol
Lrrc2provided by MGI
Official Full Name
leucine rich repeat containing 2provided by MGI
Primary source
MGI:MGI:1921499
See related
Ensembl:ENSMUSG00000032495 AllianceGenome:MGI:1921499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2400002D05Rik; 4933431K03Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human LRRC2 (leucine rich repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 15.3) and ovary adult (RPKM 1.0) See more
Orthologs
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Genomic context

See Lrrc2 in Genome Data Viewer
Location:
9 60.79 cM; 9 F2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110780613..110813134)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110951545..110984066)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated Tdgf1 proximal enhancer Neighboring gene teratocarcinoma-derived growth factor 1 Neighboring gene receptor transporter protein 3 Neighboring gene predicted gene 10030 Neighboring gene lactotransferrin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

General protein information

Preferred Names
leucine-rich repeat-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028838.2NP_083114.2  leucine-rich repeat-containing protein 2

    See identical proteins and their annotated locations for NP_083114.2

    Status: VALIDATED

    Source sequence(s)
    AC118727, AK010252
    Consensus CDS
    CCDS23580.1
    UniProtKB/Swiss-Prot
    Q8VDB8
    UniProtKB/TrEMBL
    A0A0R4J0F2
    Related
    ENSMUSP00000035076.5, ENSMUST00000035076.9
    Conserved Domains (2) summary
    COG4886
    Location:99368
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:123145
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110780613..110813134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512364.5XP_006512427.1  leucine-rich repeat-containing protein 2 isoform X1

    Conserved Domains (2) summary
    COG4886
    Location:107376
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:131153
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_006512365.5XP_006512428.1  leucine-rich repeat-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006512428.1

    UniProtKB/Swiss-Prot
    Q8VDB8
    UniProtKB/TrEMBL
    A0A0R4J0F2
    Conserved Domains (2) summary
    COG4886
    Location:99368
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:123145
    LRR_RI; leucine-rich repeat [structural motif]