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LRRC2 leucine rich repeat containing 2 [ Homo sapiens (human) ]

Gene ID: 79442, updated on 21-Dec-2019

Summary

Official Symbol
LRRC2provided by HGNC
Official Full Name
leucine rich repeat containing 2provided by HGNC
Primary source
HGNC:HGNC:14676
See related
Ensembl:ENSG00000163827 MIM:607180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]
Expression
Biased expression in heart (RPKM 15.6), thyroid (RPKM 11.1) and 9 other tissues See more
Orthologs

Genomic context

See LRRC2 in Genome Data Viewer
Location:
3p21.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (46515385..46580099, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46556875..46621589, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene lactotransferrin Neighboring gene receptor transporter protein 3 Neighboring gene LRRC2 antisense RNA 1 Neighboring gene teratocarcinoma-derived growth factor 1 Neighboring gene family with sequence similarity 240 member A Neighboring gene ALS2 C-terminal like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of leucine rich repeat containing 2 (LRRC2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
leucine-rich repeat-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021214.1 RefSeqGene

    Range
    18781..69698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024512.5NP_078788.2  leucine-rich repeat-containing protein 2

    See identical proteins and their annotated locations for NP_078788.2

    Status: REVIEWED

    Source sequence(s)
    AC098613, AJ308569, AK057808, BP420656
    Consensus CDS
    CCDS2741.1
    UniProtKB/Swiss-Prot
    Q9BYS8
    UniProtKB/TrEMBL
    A0A024R2R5
    Related
    ENSP00000379241.3, ENST00000395905.8
    Conserved Domains (3) summary
    sd00033
    Location:123145
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:167201
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:237295
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    46515385..46580099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534110.2XP_011532412.1  leucine-rich repeat-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011532412.1

    UniProtKB/Swiss-Prot
    Q9BYS8
    UniProtKB/TrEMBL
    A0A024R2R5
    Related
    ENSP00000296144.3, ENST00000296144.3
    Conserved Domains (3) summary
    sd00033
    Location:123145
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:167201
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:237295
    LRR_8; Leucine rich repeat
  2. XM_017007177.1XP_016862666.1  leucine-rich repeat-containing protein 2 isoform X2

RNA

  1. XR_001740264.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024750.3: Suppressed sequence

    Description
    NM_024750.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate due to the presence of an upstream ORF with a strong Kozak signal.
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