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VEGFB vascular endothelial growth factor B [ Homo sapiens (human) ]

Gene ID: 7423, updated on 18-Sep-2024

Summary

Official Symbol
VEGFBprovided by HGNC
Official Full Name
vascular endothelial growth factor Bprovided by HGNC
Primary source
HGNC:HGNC:12681
See related
Ensembl:ENSG00000173511 MIM:601398; AllianceGenome:HGNC:12681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VRF; VEGFL
Summary
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Expression
Broad expression in fat (RPKM 106.2), heart (RPKM 26.1) and 23 other tissues See more
Orthologs
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Genomic context

See VEGFB in Genome Data Viewer
Location:
11q13.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64234584..64239264)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64224529..64229291)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64002056..64006736)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63993887-63994406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63994407-63994924 Neighboring gene nudix hydrolase 22 Neighboring gene uncharacterized LOC124902687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3465 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3467 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64007574-64008476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64008477-64009377 Neighboring gene uncharacterized LOC114841035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64010280-64011180 Neighboring gene FKBP prolyl isomerase 2 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B Neighboring gene PPP1R14B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3470

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates members of the PDGF/VEGF growth factor family (PDGFA, VEGFA,VEGFB, VEGFC) in mammary epithelial cells PubMed
tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
tat HIV-1 Tat enhances Kaposi's sarcoma-associated herpesvirus vIL-6-induced cell proliferation, cellular transformation, vascular tube formation, and VEGF production in tumor cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor receptor 1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in coronary vasculature development IEA
Inferred from Electronic Annotation
more info
 
involved_in induction of positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in induction of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mast cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of mast cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in positive regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular wound healing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vascular endothelial growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
vascular endothelial growth factor B
Names
VEGF-related factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029823.1 RefSeqGene

    Range
    5001..9681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243733.2NP_001230662.1  vascular endothelial growth factor B isoform VEGFB-167 precursor

    See identical proteins and their annotated locations for NP_001230662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (VEGFB-167) lacks a segment in the 3' coding region, resulting in a downstream stop codon, compared to variant VEGFB-186. The resulting isoform (VEGFB-167, also known as VRF167) has a shorter and distinct C-terminus, compared to isoform VEGFB-186. This isoform contains the heparin binding domain and is mostly sequestered in the extracellular matrix.
    Source sequence(s)
    AP001453, BG031449, BM694361, BU730521, U48801
    Consensus CDS
    CCDS58144.1
    UniProtKB/TrEMBL
    Q8TEV2
    Related
    ENSP00000401550.2, ENST00000426086.3
    Conserved Domains (1) summary
    smart00141
    Location:45126
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  2. NM_003377.5NP_003368.1  vascular endothelial growth factor B isoform VEGFB-186 precursor

    See identical proteins and their annotated locations for NP_003368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (VEGFB-186) encodes the longer isoform (VEGFB-186, also known as VRF186). This isoform lacks the heparin binding domain and is secreted freely from cells.
    Source sequence(s)
    AP001453, BC008818, BM694361, BU730521
    Consensus CDS
    CCDS8062.1
    UniProtKB/Swiss-Prot
    P49765, Q16528
    UniProtKB/TrEMBL
    Q7LAP4
    Related
    ENSP00000311127.2, ENST00000309422.7
    Conserved Domains (2) summary
    PHA03269
    Location:108188
    PHA03269; envelope glycoprotein C; Provisional
    smart00141
    Location:45126
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64234584..64239264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64224529..64229291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)