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Arpc5l actin related protein 2/3 complex, subunit 5-like [ Mus musculus (house mouse) ]

Gene ID: 74192, updated on 11-Apr-2024

Summary

Official Symbol
Arpc5lprovided by MGI
Official Full Name
actin related protein 2/3 complex, subunit 5-likeprovided by MGI
Primary source
MGI:MGI:1921442
See related
Ensembl:ENSMUSG00000026755 AllianceGenome:MGI:1921442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARC16-2; 2010015J01Rik
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in glutamatergic synapse. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and integumental system. Orthologous to human ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 20.9), testis adult (RPKM 20.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 B; 2 24.42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38895283..38905889)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39008066..39015878)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 29985 Neighboring gene STARR-positive B cell enhancer ABC_E5911 Neighboring gene STARR-positive B cell enhancer ABC_E4447 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38866813-38867114 Neighboring gene WD repeat domain 38 Neighboring gene ribosomal protein L35 Neighboring gene golgin A1 Neighboring gene predicted gene, 26127 Neighboring gene STARR-positive B cell enhancer ABC_E9512 Neighboring gene suppressor of cancer cell invasion Neighboring gene predicted gene, 30067 Neighboring gene STARR-seq mESC enhancer starr_04343

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
actin-related protein 2/3 complex subunit 5-like protein
Names
arp2/3 complex 16 kDa subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418772.1NP_001405701.1  actin-related protein 2/3 complex subunit 5-like protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AL844588
  2. NM_001418773.1NP_001405702.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL844588
  3. NM_001418775.1NP_001405704.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL844588
  4. NM_001418776.1NP_001405705.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL844588
  5. NM_001418778.1NP_001405707.1  actin-related protein 2/3 complex subunit 5-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AL844588
  6. NM_028809.2NP_083085.1  actin-related protein 2/3 complex subunit 5-like protein isoform a

    See identical proteins and their annotated locations for NP_083085.1

    Status: VALIDATED

    Source sequence(s)
    AL844588
    Consensus CDS
    CCDS38120.1
    UniProtKB/Swiss-Prot
    Q9D898
    Related
    ENSMUSP00000108483.3, ENSMUST00000112862.7
    Conserved Domains (1) summary
    pfam04699
    Location:9151
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    38895283..38905889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)