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Smg8 SMG8 nonsense mediated mRNA decay factor [ Mus musculus (house mouse) ]

Gene ID: 74133, updated on 30-Apr-2024

Summary

Official Symbol
Smg8provided by MGI
Official Full Name
SMG8 nonsense mediated mRNA decay factorprovided by MGI
Primary source
MGI:MGI:1921383
See related
Ensembl:ENSMUSG00000020495 AllianceGenome:MGI:1921383
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200011M11Rik
Summary
Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of protein kinase activity. Orthologous to human SMG8 (SMG8 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.0), limb E14.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
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Genomic context

See Smg8 in Genome Data Viewer
Location:
11 C; 11 51.89 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86968558..86977603, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87077732..87086777, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22387 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1 Neighboring gene proline rich 11 Neighboring gene STARR-positive B cell enhancer ABC_E26 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene microRNA 301

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
nonsense-mediated mRNA decay factor SMG8
Names
CG6729 gene product
protein SMG8
protein smg-8 homolog
smg-8 homolog, nonsense mediated mRNA decay factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024262.1NP_077224.1  nonsense-mediated mRNA decay factor SMG8

    See identical proteins and their annotated locations for NP_077224.1

    Status: PROVISIONAL

    Source sequence(s)
    BC020005
    Consensus CDS
    CCDS25207.1
    UniProtKB/Swiss-Prot
    B2KGQ4, Q8BS62, Q8BSP7, Q8VE18, Q9DBW6
    Related
    ENSMUSP00000020801.8, ENSMUST00000020801.14
    Conserved Domains (1) summary
    pfam10220
    Location:42985
    Smg8_Smg9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86968558..86977603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)